Grand Rounds Archives - Page 27 of 30 - Rethinking Clinical Trials

September 23, 2020: NIH Collaboratory COVID-19 Grand Rounds Continues With the RADx Initiative

Posted on September 23, 2020 by Damon Seils

Photograph of Rick Bright and Rachael Fleurence In this week’s COVID-19 Grand Rounds session, Dr. Rick Bright and Dr. Rachael Fleurence of the National Institutes of Health will present “Accelerating the Nation’s COVID-19 Testing Capacity: An Update From the NIH’s RADx Program.” The Grand Rounds session will be held on Friday, September 25, at 1:00 pm eastern. Join the online meeting.

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

Previous COVID-19 Grand Rounds:

March 20, 2020: Clinical Trials in the Time of COVID-19 (Susanna Naggie, MD; Adrian Hernandez, MD, MHS; Eric Perakslis, PhD)
April 3, 2020: Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research (Harlan Krumholz, MD; Bala Hota, MD, MPH; Graham Nichol, MD, MPH)
April 10, 2020: Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial (Sean Collins, MD, MSc)
April 17, 2020: The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence (Nakela Cook, MD, MPH; Josie Briggs, MD; Susanna Naggie, MD; Emily O’Brien, PhD; Russell Rothman, MD; Chris Forrest, MD, PhD)
April 24, 2020: The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 (Martin Landray, PhD, FRCP)
May 15, 2020: Optimizing Learning While Doing: The REMAP-CAP Adaptive Platform Trial (Derek C. Angus, MD, MPH, FRCP)
June 5, 2020: PCORnet COVID-19 Common Data Model Design and Results (Thomas Carton, PhD, MS; Keith Marsolo, PhD; Jason Perry Block, MD, MPH)
July 10, 2020: COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C) (Ken Gersing, MD; Robert A. Star, MD)
August 21, 2020: Adaptive Platform Trials: Scalable from Breast Cancer to COVID (Laura Esserman, MD, MBA)
September 11, 2020: Launching CONNECTS: Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies (Gordon Bernard, MD; Sonia Thomas, DrPH)

For more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

September 16, 2020: Results of TSOS Trial to Be Announced in NIH Collaboratory Grand Rounds

Posted on September 16, 2020January 17, 2024 by Damon Seils

Photo of Dr. Doug Zatzick

The principal investigator of the Trauma Survivors Outcomes and Support (TSOS) pragmatic clinical trial, an NIH Collaboratory Trial, will announce the study’s primary results in the next session of PCT Grand Rounds on September 18.

Dr. Doug Zatzick of the University of Washington will present “The Trauma Survivors Outcomes and Support (TSOS) Pragmatic Clinical Trial: Effectiveness and Implementation Process Assessment Results.” The Grand Rounds session will be held on Friday, September 18, at 1:00 pm eastern. Join the online meeting.

TSOS was a stepped-wedge, cluster randomized clinical trial of a collaborative care intervention for injured patients with symptoms of posttraumatic stress disorder in 25 level 1 trauma centers in the United States.

TSOS is supported within the NIH Collaboratory by a cooperative agreement from the National Institute of Mental Health.

September 9, 2020: NIH Collaboratory COVID-19 Grand Rounds Continues With the CONNECTS Network of Networks

Posted on September 9, 2020September 9, 2020 by Damon Seils

In this week’s COVID-19 Grand Rounds session, Dr. Gordon Bernard of Vanderbilt University and Dr. Sonia Thomas of RTI International will present “Launching CONNECTS: Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies.” The Grand Rounds session will be held on Friday, September 9, at 1:00 pm eastern. Join the online meeting.

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

Previous COVID-19 Grand Rounds:

March 20, 2020: Clinical Trials in the Time of COVID-19 (Susanna Naggie, MD; Adrian Hernandez, MD, MHS; Eric Perakslis, PhD)
April 3, 2020: Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research (Harlan Krumholz, MD; Bala Hota, MD, MPH; Graham Nichol, MD, MPH)
April 10, 2020: Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial (Sean Collins, MD, MSc)
April 17, 2020: The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence (Nakela Cook, MD, MPH; Josie Briggs, MD; Susanna Naggie, MD; Emily O’Brien, PhD; Russell Rothman, MD; Chris Forrest, MD, PhD)
April 24, 2020: The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 (Martin Landray, PhD, FRCP)
May 15, 2020: Optimizing Learning While Doing: The REMAP-CAP Adaptive Platform Trial (Derek C. Angus, MD, MPH, FRCP)
June 5, 2020: PCORnet COVID-19 Common Data Model Design and Results (Thomas Carton, PhD, MS; Keith Marsolo, PhD; Jason Perry Block, MD, MPH)
July 10, 2020: COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C) (Ken Gersing, MD; Robert A. Star, MD)
August 21, 2020: Adaptive Platform Trials: Scalable from Breast Cancer to COVID (Laura Esserman, MD, MBA)

For more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

August 19, 2020: NIH Collaboratory COVID-19 Grand Rounds Series Puts Spotlight on Adaptive Platform Trials

Posted on August 19, 2020 by Damon Seils

Photo of Dr. Laura Esserman In this week’s COVID-19 Grand Rounds session, Dr. Laura Esserman of the University of California, San Francisco will present “Adaptive Platform Trials: Scalable From Breast Cancer to COVID.” The Grand Rounds session will be held on Friday, August 21, at 1:00 pm eastern. Join the online meeting.

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

Previous COVID-19 Grand Rounds:

March 20, 2020: Clinical Trials in the Time of COVID-19 (Susanna Naggie, MD; Adrian Hernandez, MD, MHS; Eric Perakslis, PhD)
April 3, 2020: Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research (Harlan Krumholz, MD; Bala Hota, MD, MPH; Graham Nichol, MD, MPH)
April 10, 2020: Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial (Sean Collins, MD, MSc)
April 17, 2020: The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence (Nakela Cook, MD, MPH; Josie Briggs, MD; Susanna Naggie, MD; Emily O’Brien, PhD; Russell Rothman, MD; Chris Forrest, MD, PhD)
April 24, 2020: The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 (Martin Landray, PhD, FRCP)
May 15, 2020: “Optimizing Learning While Doing: The REMAP-CAP Adaptive Platform Trial” (Derek C. Angus, MD, MPH, FRCP)
June 5, 2020: “PCORnet COVID-19 Common Data Model Design and Results” (Thomas Carton, PhD, MS; Keith Marsolo, PhD; Jason Perry Block, MD, MPH)
July 10, 2020: “COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C)” (Ken Gersing, MD; Robert A. Star, MD)

For more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

August 12, 2020: Lessons From NOHARM’s First Year Will Be Featured in NIH Collaboratory Grand Rounds

Posted on August 12, 2020January 17, 2024 by Damon Seils

The co–principal investigators of the Nonpharmacologic Options in Postoperative Hospital-Based and Rehabilitation Pain Management (NOHARM) trial, an NIH Collaboratory Trial, will be featured in the next session of NIH Collaboratory Grand Rounds on August 14. The project is 1 of 4 NIH Collaboratory Trials funded through the NIH HEAL Initiative’s Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) program.

Drs. Jon Tilburt and Andrea Cheville of the Mayo Clinic will present “Learning While Sprinting: A One-Year Retrospective From the NOHARM Pragmatic Trial.” The Grand Rounds session will be held on Friday, August 14, at 1:00 pm eastern. Join the online meeting.

NOHARM will test a patient- and clinician-facing clinical decision support tool embedded in the electronic health record in 4 healthcare systems. Such tools can be useful in encouraging patient-centered, guideline-concordant care, but pragmatic strategies have not been tested pragmatically in postoperative pain care.

NOHARM is supported by the NIH through the NIH HEAL Initiative under an award from the National Institute on Aging.

July 22, 2020: FM TIPS NIH Collaboratory Trial Will Be Featured During NIH Collaboratory Grand Rounds

Posted on July 22, 2020January 16, 2024 by Damon Seils

A co–principal investigator of the Fibromyalgia TENS in Physical Therapy Study (FM TIPS), an NIH Collaboratory Trial supported by the NIH HEAL Initiative, will be featured in the next session of NIH Collaboratory Grand Rounds on July 24. The project is the first of the NIH Collaboratory Trials funded through the Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) program to be featured in Grand Rounds.

Dr. Leslie Crofford of Vanderbilt University will present “TENS in Fibromyalgia: From Fundamental Neurobiology to Pragmatic Trial.” The Grand Rounds session will be held on Friday, July 24, at 1:00 pm eastern. Join the online meeting.

FM TIPS will use a cluster randomized trial design to assess the feasibility of using transcutaneous electrical nerve stimulation (TENS) in addition to physical therapy for the treatment of fibromyalgia. The study will also determine whether the use of TENS improves symptoms of fibromyalgia, increases adherence to physical therapy and the likelihood of meeting therapeutic goals, and reduces medication use. FM TIPS is currently in the planning phase, which involves recruiting physical therapy sites into the embedded pragmatic clinical trial, understanding usual practice to inform trial processes, and ensuring the adequacy of trial infrastructure.

FM TIPS is supported by the NIH through the NIH HEAL Initiative under an award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

July 15, 2020: Living Textbook Grand Rounds Series Continues With “Choosing What to Measure and Making It Happen”

Posted on July 15, 2020July 15, 2020 by Damon Seils

Join us Friday, July 17, for “Choosing What to Measure and Making It Happen: Your Keys to Pragmatic Trial Success,” the final session in our special 5-part Grand Rounds series focused on the Living Textbook of Pragmatic Clinical Trials. NIH Collaboratory investigators Drs. Rachel Richesson and Devon Check will discuss endpoints and outcome measures in pragmatic clinical trials embedded in healthcare systems. Topics covered will include:

The ins and outs of using EHR data
Choosing and specifying your trial’s endpoints and outcomes

See below for the full schedule of Living Textbook sessions and a special message from Dr. Kevin Weinfurt.

**Living Textbook Grand Rounds Series**
Date	Title	Speakers
January 31, 2020	Pragmatic Clinical Trials: How Do I Start?	Greg Simon, MD, MPH, Kaiser Permanente Washington Health Research Institute Lesley H. Curtis, PhD, Duke University
February 28, 2020	Preparing for the Unknown: Conducting Pragmatic Research in Real-World Contexts	Jerry Jarvik, MD, MPH, University of Washington Vince Mor, PhD, Brown University Leah Tuzzio, MPH, Kaiser Permanente Washington Health Research Institute
March 27, 2020	Tips for Putting Together a Successful PCT Grant Application	Wendy Weber, ND, PhD, MPH, National Center for Complementary and Integrative Health
June 19, 2020	Demystifying Biostatistical Concepts for Embedded Pragmatic Clinical Trials	Liz Turner, PhD, Duke University Patrick Heagerty, PhD, University of Washington David M. Murray, PhD, National Institutes of Health
July 17, 2020	Choosing What to Measure and Making It Happen: Your Keys to Pragmatic Trial Success	Rachel Richesson, PhD, MPH, Duke University Devon Check, PhD, Duke University

July 14, 2020: Grand Rounds Webinar Presents the New N3C Analytics Platform for COVID-19 Research

Posted on July 14, 2020July 22, 2020 by Gina Uhlenbrauck

Watch the recent Grand Rounds webinar presented by Dr. Ken Gersing of the National Center for Advancing Translational Sciences and Dr. Robert Star of the National Institute of Diabetes and Digestive and Kidney Diseases to learn more about the COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C).

The N3C initiative aims to build a centralized national data resource that researchers can use to study COVID-19 and identify potential treatments as the pandemic continues to evolve. N3C is a partnership among the Clinical and Translational Science Awards Program hubs and the National Center for Data to Health, with overall stewardship by the National Center for Advancing Translational Sciences (NCATS).

The goals of N3C are to:

Rapidly collect and aggregate clinical, lab, and imaging data from hospitals, health plans, and CMS at the peak of the COVID-19 pandemic and as it evolves
Provide a longitudinal dataset to understand acute hospital and recovery phases
Understand pathophysiology of disease
Support clinical trials by identifying patients who might wish to participate in trials

Watch the Grand Rounds webinar or download the slides. For more details, visit the NCATS N3C website.

July 8, 2020: NIH Collaboratory EHR Workshop Summary Podcast Led by the NIH’s Dr. Wendy Weber Now Available

Posted on July 8, 2020January 17, 2024 by Damon Seils

The latest episode of the NIH Collaboratory Grand Rounds Podcast is now available on the Living Textbook. This conversation, led by Dr. Wendy Weber of the National Center for Complementary and Integrative Health, reflects on the NIH Collaboratory’s special EHR workshop Grand Rounds series, “Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials.”

The conversation takes a look back at the special EHR workshop series. Participants include Dr. Lesley Curtis, co–principal investigator of the NIH Collaboratory Coordinating Center, along with Drs. Patrick Heagerty and Keith Marsolo, who moderated webinars included in this Grand Rounds series.

In this episode, you will learn more about:

Use of digital technologies in pragmatic clinical trials
Lessons learned from the NIH Collaboratory Trials
How existing data structures and platforms could be expanded to disseminate evidence to decision makers

July 8, 2020: NIH Collaboratory COVID-19 Grand Rounds Series Continues With the National COVID Cohort Collaborative Data Enclave

Posted on July 8, 2020 by Damon Seils

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

In this week’s COVID-19 Grand Rounds session, Dr. Ken Gersing of the National Center for Advancing Translational Sciences and Dr. Robert Star of the National Institute of Diabetes and Digestive and Kidney Diseases will present “COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C).” The Grand Rounds session will be held on Friday, July 10, at 1:00 pm eastern. Join the online meeting.

Drs. Gersing and Star will discuss the recent launch by the NIH of a centralized data repository and analytics platform, the N3C Data Enclave, to store and study large quantities of medical record data from people diagnosed with COVID-19 in the United States.

Previous COVID-19 Grand Rounds:

March 20, 2020: Clinical Trials in the Time of COVID-19 (Susanna Naggie, MD; Adrian Hernandez, MD, MHS; Eric Perakslis, PhD)
April 3, 2020: Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research (Harlan Krumholz, MD; Bala Hota, MD, MPH; Graham Nichol, MD, MPH)
April 10, 2020: Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial (Sean Collins, MD, MSc)
April 17, 2020: The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence (Nakela Cook, MD, MPH; Josie Briggs, MD; Susanna Naggie, MD; Emily O’Brien, PhD; Russell Rothman, MD; Chris Forrest, MD, PhD)
April 24, 2020: The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 (Martin Landray, PhD, FRCP)
May 15, 2020: “Optimizing Learning While Doing: The REMAP-CAP Adaptive Platform Trial” (Derek C. Angus, MD, MPH, FRCP)
June 5, 2020: “PCORnet COVID-19 Common Data Model Design and Results” (Thomas Carton, PhD, MS; Keith Marsolo, PhD; Jason Perry Block, MD, MPH)

For more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.