Our Impact
The NIH Pragmatic Trials Collaboratory is the nation's leading resource on how to conduct clinical research in partnership with healthcare systems. For over a decade, the program has helped rigorous trials be successful in real-world settings, creating standards for more efficient, large-scale clinical research. Learn more about how the program gathers and shares knowledge to advance research methods and benefit other trials.
publications*
citations of our work
website visitors/year
Grand Rounds webinars
*As of December 31, 2025
Supporting strides toward a learning health system through...
NIH Collaboratory Trials
Our 37 NIH Collaboratory Trials answer important clinical questions through rigorous research embedded in healthcare delivery. Together, they have included >1.2 million patients, 1400 clinical sites, and 49 US states and Puerto Rico.
Core Working Groups
The program's 7 Core Working Groups support the NIH Collaboratory Trials by offering guidance and consultations, in addition to producing high-impact publications, information, and tools to benefit the entire pragmatic research community.
Dissemination
We disseminate the latest knowledge and best practices in pragmatic trials through a variety of mechanisms. In addition to journal publications, we produce a weekly Grand Rounds webinar, a free online textbook, a podcast, robust training offerings, and more.
For Funders and Partners
Pragmatic trials are an opportunity to advance research priorities such as:
- Including more representative populations
- Expanding research to rural areas
- Creating community partnerships
The NIH Pragmatic Trials Collaboratory has worked with 16 NIH Institutes and Centers and the HEAL Initiative to provide consultative services for diverse trials across clinical areas, and new trials are added as needs arise. Researchers establish their own partnerships with healthcare systems, so the possibilities for sites are unlimited. Many investigators from NIH Collaboratory Trials have returned to conduct more trials within the program, a testament to its value for researchers.
The program also partners with >40 national and international organizations to exchange knowledge, offer expertise, and advance methods for clinical research embedded in healthcare delivery settings. We encourage use and sharing of our program materials, training resources, Living Textbook content, study tools, and products. Groups interested in partnering with the NIH Collaboratory may contact nih-collaboratory@duke.edu.
Our partners include:
