Skip to content

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
  • Home
  • About
    • NIH Collaboratory
      • Coordinating Center
      • NIH Collaboratory Trials
      • Core Working Groups
      • Steering Committee
      • Distributed Research Network
      • Our Impact
    • Living Textbook
      • Table of Contents
      • How to Use This Site
  • Resources
    • Data and Resource Sharing
    • Training Resources
    • Tools for Researchers
    • Publications
    • Knowledge Repository
  • Webinar
  • Podcast
  • News
    • News Feed
    • Calendar
    • Subscribe
return to home
Subscribe to Newsletter go to twitter feed go to linkedin go to blue sky feed
Search
NIH Collaboratory
Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
home button

Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures

Introduction

CHAPTER SECTIONS

Dissemination Approaches for Different Audiences


Section 1

Introduction

Expand Contributors

Hayden B. Bosworth, PhD
David Chambers, DPhil
Ellen Tambor, MA
Beverly B. Green, MD, MPH
Susan Huang, MD, MPH
Kevin P. Weinfurt, PhD
Doug Zatzick, MD

Contributing Editor
Damon M. Seils, MA

Clinical researchers traditionally have reported their study results in scientific journals. The results of pragmatic clinical research are often used to inform clinical and healthcare system decision-makers, frame clinical guidelines, and inform policy and, ultimately, may be implemented into routine care or clinical operations. A shift has begun toward using dissemination strategies that shorten the time it takes for research findings to change clinical practice and benefit patient care (Balas and Boren 2000).

The mode and medium for disseminating the findings of a pragmatic clinical trial should be tailored to the specific audience. The Patient-Centered Outcomes Research Institute (PCORI) recommends that patients and other research partners be involved in plans to disseminate study findings by, for example, identifying the audiences for dissemination, shaping the study design with dissemination in mind, and developing creative approaches to getting information into the hands of those who need it.

Having research partners at the table from the start can be key to driving practice change if it is indicated from the results or to redesign or adjust if results are not as expected. The Building Partnerships and Teams to Ensure a Successful Trial chapter of the Living Textbook describes the wide range of research partner groups relevant to pragmatic trials.

This chapter explores dissemination strategies for different audiences, including considerations for transparent reporting to the scientific community and approaches for disseminating results to patients, clinicians, and healthcare system leaders.

Learn more in these Living Textbook chapters:

  • Implementation
  • Building Partnerships and Teams to Ensure a Successful Trial

Next Section

SECTIONS

CHAPTER SECTIONS

sections

  1. Introduction
  2. Reporting to the Scientific Community
  3. Case Study: Journal Reviews of NIH Collaboratory Trials
  4. ClinicalTrials.gov
  5. Dissemination to Patients
  6. Dissemination to Clinicians and Health Systems
  7. Dissemination Case Studies
  8. Additional Resources

Resources

Dissemination Opportunities for Pragmatic Trials
A reference offering examples of strategies beyond academic publications to help investigators plan for broad dissemination


Data and Resource Sharing
Resources from the NIH Collaboratory Trials, including protocols, consent documents, public use datasets, computable phenotypes, and analytic code

REFERENCES

back to top

Balas EA, Boren SA. 2000. Managing clinical knowledge for health care improvement. Yearb Med Inform. 2000;(1):65-70. PMID: 27699347.

back to top

ACKNOWLEDGMENTS

back to top

Karen Staman, Gina Uhlenbrauck, and Liz Wing of the NIH Pragmatic Trials Collaboratory Coordinating Center served as contributing editors for previous versions of this chapter.


Version History

February 4, 2026: Added the Dissemination Opportunities for Pragmatic Trials handout to the Resources sidebar (changes made by D. Seils).

Published November 24, 2025.

current section :

Introduction

  1. Introduction
  2. Reporting to the Scientific Community
  3. Case Study: Journal Reviews of NIH Collaboratory Trials
  4. ClinicalTrials.gov
  5. Dissemination to Patients
  6. Dissemination to Clinicians and Health Systems
  7. Dissemination Case Studies
  8. Additional Resources

Citation:

Bosworth HB, Chambers D, Tambor E, Green BB, Huang S, Weinfurt KP, Zatzick D. Dissemination Approaches for Different Audiences: Introduction. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Pragmatic Trials Collaboratory. Available at: https://rethinkingclinicaltrials.org/chapters/dissemination/dissemination-approaches-for-different-audiences/introduction-dissemination-approaches-for-different-audiences/. Updated February 4, 2026. DOI: 10.28929/290.

Footer Menu

  • How to Use This Site
  • About NIH Collaboratory
  • Enrollment Reporting
  • Grand Rounds
  • Funding Statement
Link to Twitter Link to LinkedIn Link to Blue Sky Link to NIH Collaboratory email

Reference in this Web site to any specific commercial products, process, service, manufacturer, or company does not constitute its endorsement or recommendation by the U.S. Government or National Institutes of Health (NIH). NIH is not responsible for the contents of any “off-site” Web page referenced from this server.

Log in
Privacy Statement
WordPress is a content management system and should not be used to upload any PHI as it is not an environment for which we exercise oversight, meaning you the author are responsible for the content you post. Please use this system accordingly. Site Map