Vincent Mor, PhD
Florence Pirce Grant University Professor
Department of Health Services Policy & Practice
Brown University School of Public Health
Leah Tuzzio, MPH
Kaiser Permanente Washington Health Research Institute
Jeffrey (Jerry) G. Jarvik MD MPH
Professor, Radiology, Neurological Surgery and Health Services
Adjunct Professor, Pharmacy and Orthopedics & Sports Medicine
University of Washington
Preparing for the Unknown: Conducting Pragmatic Research in Real-World Contexts
Embedded research; Implementation; Healthcare systems; Nursing homes; Radiology reports; Electronic health records; Data collection; Pragmatic clinical trials
- Early engagement between study teams and health system leaders and staff can help ease the embedded intervention into the clinical workflow. Consider, for example, who will deliver the intervention and how difficult it will be to implement.
- In the pilot phase, show that you can implement the intervention effectively. For example, demonstrate that you can collect the outcome data you will need within the pilot’s time frame. Ensure that your study questions are important to the partner healthcare system.
It is essential to anticipate, identify, and make a plan to address changes in the healthcare system as your trial is being conducted.
Among the Collaboratory Demonstration Projects, many have good measures of how much site-to-site variation there is, which helps to understand what the preconditions are for high levels of implementation.
Use the pilot study to maximize acceptability, maintain affordability, and consider the scalability of the intervention.