Grand Rounds

May 17, 2024: This Week’s PCT Grand Rounds to Feature the CardioHealth Alliance

Posted on by Damon Seils
Dr. Ken Mahaffey, Dr. Nishant Shah, and Dr. Neha Pagidipati

In this Friday’s PCT Grand Rounds, Ken Mahaffey of Stanford University and Nishant Shah and Neha Pagidipati of Duke University will present “CardioHealth Alliance: A Platform to Improve Care.”

The Grand Rounds session will be held on Friday, May 17, 2024, at 1:00 pm eastern.

Mahaffey is the associate dean for clinical research in the Stanford University School of Medicine and the director of the Stanford Center for Clinical Research. Shah is an assistant professor of medicine in the Duke University School of Medicine and the principal investigator for the REVEAL Project: Identifying Real World Gaps and Areas for Improvement. Pagidipati is an associate professor of medicine in the Duke University School of Medicine and the principal investigator for the Test to Treat: Improving Lipid Management on a Health System Level.

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May 1, 2024: PKIDS Pragmatic Trial to Be Featured in PCT Grand Rounds

Posted on by Damon Seils
Headshot of Dr. Gregory Tasian
Dr. Gregory Tasian

In this Friday’s PCT Grand Rounds, Gregory Tasian of the Children’s Hospital of Philadelphia will present “Comparative Effectiveness of Kidney Stone Surgery in Pediatric Patients: The PKIDS Trial.”

The Grand Rounds session will be held on Friday, May 3, 2024, at 1:00 pm eastern.

The Pediatric Kidney Stone (PKIDS) Care Improvement Network Trial is a patient-centered, pragmatic clinical trial comparing the effectiveness of 3 surgical modalities on stone clearance in youth with kidney stones and evaluating heterogeneity of treatment effect by stone size and location. Tasian is an associate professor of surgery and epidemiology at the Children’s Hospital of Philadelphia.

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April 24, 2024: Developments in Waivers and Alterations of Informed Consent in Minimal-Risk Research, in This Week’s PCT Grand Rounds

Posted on by Damon Seils

Dr. Lauren Milner, Dr. Jonathan Casey, and Dr. Matthew Semler

In this Friday's PCT Grand Rounds, Lauren Milner of the US Food and Drug Administration (FDA) and Jonathan Casey and Matthew Semler of Vanderbilt University will present "Waiver or Alteration of Informed Consent for Minimal Risk Clinical Investigations – FDA Regulation Development and Research Landscape."

The Grand Rounds session will be held on Friday, April 26, 2024, at 1:00 pm eastern.

Milner is a regulatory policy adviser in the FDA's Office of Clinical Policy. Casey is an assistant professor of medicine and the director of the coordinating center for the Pragmatic Critical Care Research Group at Vanderbilt University Medical Center. Semler is an associate professor of medicine and codirector of the Vanderbilt Center for Learning Healthcare at Vanderbilt University Medical Center.

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April 17, 2024: In This Week’s PCT Grand Rounds, 10 Years of the YODA Project

Posted on by Damon Seils

Headshot of Dr. Joseph Ross
Dr. Joseph Ross

In this Friday’s PCT Grand Rounds, Joseph Ross of Yale University will present “The Yale Open Data Access (YODA) Project: 10 Years of Clinical Trial Data Sharing.”

The Grand Rounds session will be held on Friday, April 19, 2024, at 1:00 pm eastern.

The YODA Project promotes open science, research transparency, and the sharing of clinical research data to support healthcare research. Through the project, researchers can request access to deidentified participant-level clinical trial data and research reports.

Ross is a professor of medicine and public health at Yale University and codirector of the YODA Project.

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April 10, 2024: Primary Results of PRIM-ER Trial to Be Featured in This Week’s PCT Grand Rounds

Posted on by Damon Seils

Headshot of Dr. Corita Grudzen
Dr. Corita Grudzen, principal investigator of PRIM-ER

In this Friday’s PCT Grand Rounds, Corita Grudzen of the Memorial Sloan Kettering Cancer Center will present “Primary Palliative Care for Emergency Medicine, a Cluster Randomized Stepped-Wedge Trial Across 33 Emergency Departments,” including the results of the PRIM-ER trial.

The Grand Rounds session will be held on Friday, April 12, 2024, at 1:00 pm eastern.

Grudzen is a professor of emergency medicine at Weill Cornell Medical College and the Fern Grayer Chair in Oncology Care and the Patient Experience and division head of supportive and acute care services at the Memorial Sloan Kettering Cancer Center.

PRIM-ER, an NIH Collaboratory Trial, is a stepped-wedge, cluster randomized trial testing a multidisciplinary primary palliative care intervention in a diverse mix of emergency departments in the United States. The study is supported within the NIH Pragmatic Trials Collaboratory by a cooperative agreement from the National Institute on Aging. Read more about PRIM-ER.

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April 3, 2024: In This Week’s PCT Grand Rounds, a New Look at P Values for Randomized Trials

Posted on by Damon Seils

Dr. Erik van Zwet

In this Friday’s PCT Grand Rounds, Erik van Zwet of Leiden University Medical Center will present “A New Look at P Values for Randomized Clinical Trials.”

The Grand Rounds session will be held on Friday, April 5, 2024, at 1:00 pm eastern.

Dr. van Zwet is an associate professor in the Department of Biomedical Data Sciences at Leiden University Medical Center in the Netherlands.

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March 27, 2024: A Cluster Randomized Trial to Improve Kidney Transplant Access, in This Week’s PCT Grand Rounds

Posted on by Damon Seils

Drs. Amit Garg and Stephanie Dixon

In this Friday’s PCT Grand Rounds, Amit Garg and Stephanie Dixon of Western University’s Schulich School of Medicine and Dentistry will present “Effect of a Multicomponent Intervention to Improve Patient Access to Kidney Transplant and Living Kidney Donation: A Pragmatic, Cluster-Randomized Trial.”

The Grand Rounds session will be held on Friday, March 27, 2024, at 1:00 pm eastern.

Garg is the associate dean for clinical research at the Schulich School of Medicine and Dentistry and the lead of the provincial Kidney, Dialysis and Transplantation Program of the Institute for Clinical Evaluative Sciences (ICES KDT). Dixon is a biostatistician at the London Health Sciences Centre and the program manager for ICES KDT.

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March 20, 2024: Early Diagnosis and Assessment of Autism to Be Featured in This Week’s PCT Grand Rounds

Posted on by Damon Seils

Headshot of Dr. Warren Jones
Dr. Warren Jones

In this Friday’s PCT Grand Rounds, Warren Jones of Emory University will present “Early Diagnosis and Assessment of Autism via Objective Measurements of Social Visual Engagement.”

The Grand Rounds session will be held on Friday, March 22, 2024, at 1:00 pm eastern.

Jones is the director of research at the Marcus Autism Center and the Norman Nien Distinguished Chair in Autism and an associate professor of pediatrics at the Emory University School of Medicine.

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March 13, 2024: In This Friday’s PCT Grand Rounds, a Pragmatic Trial of Antibiotic Choice on Renal Outcomes

Posted on by Damon Seils

Headshot of Dr. Edward Qian
Dr. Edward Qian

In this Friday's PCT Grand Rounds, Edward Qian of Vanderbilt University will present "The Effect of Antibiotic Choice on Renal Outcomes: The ACORN Trial."

The Grand Rounds session will be held on Friday, March 15, 2024, at 1:00 pm eastern.

The ACORN trial compared the effects of cefepime vs piperacillin-tazobactam on the incidence of acute kidney injury among acutely ill adults. In this innovative study, randomization of eligible patients occurred at the prescriber level within the electronic medical record.

Qian, the principal investigator for ACORN, is an assistant professor of medicine and the assistant director for quality and education of the medical ICU at the Vanderbilt University Medical Center.

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March 6, 2024: In This Week’s PCT Grand Rounds, Public-Private Partnerships in Health AI

Posted on by Damon Seils

In this Friday’s PCT Grand Rounds, Michael Pencina of Duke University will present “Public-Private Partnerships in the Trustworthy Health AI Ecosystem.”

The Grand Rounds session will be held on Friday, March 8, 2024, at 1:00 pm eastern.

Pencina is a professor of biostatistics and bioinformatics and the vice dean for data science in the Duke University School of Medicine. He is the director of the university’s Duke AI Health initiative and the chief data scientist for Duke Health.

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