Core Working Groups

Core Working Groups

Active Cores

Core Description
Biostatistics and Study Design Creates guidance and technical documents regarding study design and biostatistical issues; develops case studies; and allies with collaborators, Demonstration Project investigators, and academic institutions to gather input into key methodological issues.
Electronic Health Records Created the NIH Collaboratory Distributed Research Network to enable distributed remote analysis of research datasets across health systems and act as the key repository for the tools and infrastructure we create to leverage EHRs to support clinical research across multiple health systems.
Health Care Systems Interactions Engages those involved in healthcare delivery systems to participate in research, facilitate the design and conduct of research protocols attractive to practitioners, lower administrative barriers, and communicate results to all parties.
Patient-Centered Outcomes Creates guidelines and defines best practices with respect to (1) selecting, compiling, and curating the most appropriate PRO measures (and stimulating the development of new instruments when new solutions are needed); (2) the creation efficient, high-quality PRO data collection systems compatible with EHRs and registries; and (3) conducting statistical analyses of PRO endpoints.
Ethics and Regulatory Develops policies and practices to provide a framework for the conduct of health systems research in an ethical manner and in compliance with federal and state regulations. Also, identifies areas of uncertainty and aids the NIH Collaboratory and its network in resolving uncertainty through dialogue or empirical research when needed.

Inactive Cores

Core Description
Stakeholder Engagement Established an external stakeholder advisory group to bring diverse perspectives to the work of the NIH Collaboratory. Provided feedback on study design and implementation issues, as well as methods for disseminating best practices to a broad audience of healthcare systems and other stakeholders.

In 2017, the NIH Collaboratory Coordinating Center conducted a series of interviews with the leaders of these Cores to hear reflections on accomplishments during the first 5 years.


Core Working Groups: Core Working Groups. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Health Care Systems Research Collaboratory. Available at: Updated November 11, 2019.