The NIH Collaboratory is designed in part to support the design and rapid execution of several pragmatic clinical trial Demonstration Projects. These projects address questions of major public health importance and engage healthcare delivery systems in research partnerships. The data, tools, and resources produced by the Demonstration Projects will be made available to the greater research community to facilitate a broadened base of partnerships with healthcare systems. A UH2/UG3 is a cooperative agreement that supports the development of exploratory or innovative research activities (considered a pilot phase for feasibility assessment), and a UH3 award provides support for the second phase of research activities initiated with the UH2/UG3.
The lessons learned from the first 4 years of the Collaboratory and experiences with the Demonstration Projects are highlighted in the article Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory. The authors highlight some of the challenges encountered and solutions developed and discuss remaining barriers and opportunities for large-scale evidence generation using pragmatic clinical trials.
For a list of NIH staff supporting the Demonstration Projects, please see the NIH Implementation Team.
Drs. Lesley Curtis, Adrian Hernandez, and Catherine Meyers share their enthusiasm for the 6 new UG3 Demonstration Projects, which include new areas of expertise, such as pediatrics, new digital technologies, and the Collaboratory’s first A vs B trial.
|Title||Principal Investigator||Sponsoring Institution||Phase|
|Active Bathing to Eliminate (ABATE) Infection||Huang, Susan||University of California, Irvine||UH3|
|Lumbar Imaging with Reporting of Epidemiology (LIRE)||Jarvik, Jeffrey||University of Washington||UH3|
|Collaborative Care for Chronic Pain in Primary Care (PPACT)||DeBar, Lynn||Kaiser Foundation||UH3|
|Strategies and Opportunities to Stop Colorectal Cancer (STOP CRC)||Coronado, Gloria||Kaiser Foundation Research Institute||UH3|
|Time to Reduce Mortality in End-Stage Renal Disease (TiME)||Dember, Laura||University of Pennsylvania||UH3|
NIH Collaboratory Demonstration Project Site Distribution
NIH Collaboratory Demonstration Projects are active in health systems across the United States, as shown in the map below.