NIH Collaboratory Trials
Our Reach
These large-scale pragmatic clinical trials are conducted in partnership with healthcare systems. They cover a range of clinical areas spanning 14 NIH Institutes and Centers. Together, the trials include >940,000 patient participants.
PRISM Trials
AIM-CP
Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients with Chronic Pain
Sebastian Tong, MD, MPH
Kushang Patel, PhD, MPH
University of Washington
ARBOR-Telehealth
Advancing Rural Back Pain Outcomes through Rehabilitation Telehealth
Richard L. Skolasky Jr., ScD, MA
Kevin McLaughlin, DPT
Johns Hopkins University
BackInAction
Pragmatic Trial of Acupuncture for Chronic Low Back Pain in Older Adults (BackInAction)
Lynn DeBar, Andrea J. Cook
Kaiser Foundation Research Institute
BeatPain Utah
Julie Fritz
University of Utah
FM-TIPS
Fibromyalgia TENS in Physical Therapy Study (FM-TIPS)
Leslie Crofford, Kathleen Sluka
University of Iowa
GRACE
Ardith Doorenbos, Judith Schlaeger, Robert Molokie, Miriam Ezenwa, Nirmish Shah
University of Illinois at Chicago
NOHARM
Nonpharmacologic Options in Postoperative Hospital-based and Rehabilitation Pain Management (NOHARM)
Andrea Cheville, Jon Tilburt
Mayo Clinic Rochester
OPTIMUM
Natalia Morone
Boston Medical Center
RAMP
Diana Burgess, PhD
Roni L. Evans, DC, MS, PhD
Katherine E. Hadlandsmyth, PhD
Center for Veterans Research and Education
Other Active Trials
ACP PEACE
James Tulsky, Angelo Volandes
Dana-Farber Cancer Institute
BEST-ICU
Behavioral Economic and Staffing Strategies to Increase Adoption of the ABCDEF Bundle in the ICU
Michele Balas, Eduard Vasilevskis
University of Nebraska Medical Center
Chat 4 Heart Health
Michael Ho, Sheana Bull
University of Colorado Denver
GGC4H
Margaret Kuklinski, Stacy Sterling
University of Washington
HiLo
Myles Wolf
Duke University
I CAN DO Surgical ACP
Elizabeth Wick, Genevieve Melton-Meaux, Rebecca Sudore
University of California, San Francisco
ICD-Pieces
Improving Chronic Disease Management with Pieces (ICD-Pieces)
Miguel Vazquez
UT Southwestern Medical Center
IMPACt-LBP
Implementation of the American College of Physicians Guideline for Low Back Pain (IMPACt-LBP)
Christine Goertz, Adam Goode, Jon Lurie, Hrishikesh Chakraborty
Duke University
INSPIRE
INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients
Susan S. Huang, Rich Platt, Shruti Gohil
Harvard Pilgrim Health Care
iPATH
Sara Singer, PhD, MBA
Stanford University
MOMs Chat & Care Study
Stephanie L. Fitzpatrick, PhD
Feinstein Institute for Medical Research
Nudge
Michael Ho, Sheana Bull
University of Colorado
PRIM-ER
Primary Palliative Care for Emergency Medicine (PRIM-ER)
Corita Grudzen, Keith Goldfeld
New York University School of Medicine
TAICHIKNEE
Remote Tai Chi for Knee Osteoarthritis: an Embedded Pragmatic Trial
Chenchen Wang, Helen Lavretsky, Eric Roseen, Robert Saper
Tufts Medicine Tufts Medical Center
Completed Trials
ABATE Infection
Active Bathing to Eliminate (ABATE) Infection
Susan Huang
University of California, Irvine
EMBED
Edward Melnick, Gail D'Onofrio
Yale University
PROVEN
Pragmatic Trial of Video Education in Nursing Homes (PROVEN)
Vincent Mor, Angelo Volandes, Susan Mitchell
Brown University School of Medicine
SPOT
Suicide Prevention Outreach Trial (SPOT)
Gregory Simon
Kaiser Permanente Washington Health Research Institute
STOP CRC
Strategies and Opportunities to Stop Colorectal Cancer (STOP CRC)
Gloria Coronado
Kaiser Foundation Research Institute
TiME
Time to Reduce Mortality in End-Stage Renal Disease (TiME)
Laura Dember
University of Pennsylvania
TSOS
Douglas Zatzick
University of Washington
Inactive
Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory highlights NIH Collaboratory Trial experiences.