The NIH Collaboratory is designed in part to support the design and rapid execution of several pragmatic clinical trial Demonstration Projects. These projects address questions of major public health importance and engage healthcare delivery systems in research partnerships. The data, tools, and resources produced by the Demonstration Projects will be made available to the greater research community to facilitate a broadened base of partnerships with healthcare systems. A UH2/UG3 is a cooperative agreement that supports the development of exploratory or innovative research activities (considered a pilot phase for feasibility assessment), and a UH3 award provides support for the second phase of research activities initiated with the UH2/UG3.
The lessons learned from the first 4 years of the Collaboratory and experiences with the Demonstration Projects are highlighted in the article Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory. The authors highlight some of the challenges encountered and solutions developed and discuss remaining barriers and opportunities for large-scale evidence generation using pragmatic clinical trials.
Drs. Lesley Curtis, Adrian Hernandez, and Catherine Meyers share their enthusiasm for the 6 new UG3 Demonstration Projects, which include new areas of expertise, such as pediatrics, new digital technologies, and the Collaboratory’s first A vs B trial.
In 2017, the NIH Collaboratory Coordinating Center conducted a series of interviews with the Principal Investigators of these Demonstration Projects to share challenges and lessons learned that may help in the conduct of future pragmatic trials.
NIH Collaboratory Demonstration Project Site Distribution
NIH Collaboratory Demonstration Projects are active in health systems across the United States, as shown in the map below. Hover over a pin for more information.
*Please note that pins may represent more than one site per state, and the pin location is not an exact representation.
NH Health Care Systems Research Collaboratory Implementation Team
David Shurtleff, PhD, Co-Chair (NCCIH)
Catherine M. Meyers, Assistant to the Chair (NCCIH)
Barbara Wells, Assistant to the Chair (NHLBI)
|Kevin C. Abbott (NIDDK)||Jeri Miller (NINR)|
|Robin Boineau (NCCIH)||Andrew Narva (NIDDK)|
|Erica Breslau (NCI)||Jane Pearson (NIMH)|
|Leslie Derr (OD/OSC)||Linda L. Porter (NINDS)|
|Gregory Deye (NIAID)||Matthew Rudorfer (NIMH)|
|Sarah Duffy (NIDA)||Marcel Salive (NIA)|
|Brett Hagman (NIAAA)||Jerry Suls (NCI)|
|Clayton Huntley (NIAID)||Chuck Washabaugh (NIAMS)|
|Paul Kimmel (NIDDK)||Wendy Weber (NCCIH)|
Executive Secretary: Christina Brackna (NCCIH)
Advisors: Elaine Collier (NCATS) and Debra Egan (NCCIH)
UH3 Demonstration Projects: Principal Investigators
Back left to right: Doug Zatzick, Greg Simon, Miguel Vazquez, Vince Mor, Jerry Jarvik
Front left to right: Bev Green, Lynn DeBar, Susan Huang, Laura Dember, Gloria Coronado