Grand Rounds

February 2, 2021: NIH Collaboratory COVID-19 Grand Rounds Continues With the Brazilian COALITION Experience

Posted on by Damon Seils

Dr. Renato LopesIn this week’s COVID-19 Grand Rounds session, Dr. Renato Lopes of Duke University and the Brazilian Clinical Research Institute, will present “Generating High-Quality Evidence During a Pandemic: The Brazilian COALITION Experience.” The Grand Rounds session will be held on Friday, February 5, at 1:00 pm eastern. Join the online meeting.

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

For previous COVID-19 Grand Rounds, and more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

January 26, 2021: NIH Collaboratory COVID-19 Grand Rounds Continues With the COVID-19 Citizen Science Study

Posted on by Damon Seils

Dr. Gregory MarcusIn this week’s COVID-19 Grand Rounds session, Dr. Gregory Marcus of the University of California, San Francisco, will present “The COVID-19 Citizen Science Study.” The Grand Rounds session will be held on Friday, January 29, at 1:00 pm eastern. Join the online meeting.

The Citizen Science Study is using a smartphone-based research platform to engage “citizen scientists” in advancing understanding of COVID-19. By collecting information from tens of thousands of participants, researchers hope to gain insights into how the coronavirus is spreading, identify ways to reduce the number of new infections, and determine how COVID-19 is affecting individuals and populations.

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

For previous COVID-19 Grand Rounds, and more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

January 14, 2021: NIH Collaboratory COVID-19 Grand Rounds Continues With Clinical Trials Challenges in the COVID-19 Pandemic

Posted on by Damon Seils

Dr. Pamela TenaertsIn this week’s COVID-19 Grand Rounds session, Dr. Pamela Tenaerts of the Clinical Trials Transformation Initiative will present “How CTTI & the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic.” The Grand Rounds session will be held on Friday, January 15, at 1:00 pm eastern. Join the online meeting.

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

For previous COVID-19 Grand Rounds, and more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

January 6, 2021: NIH Collaboratory COVID-19 Grand Rounds Continues With HERO-TOGETHER Long-Term Safety Study

Posted on by Damon Seils

Dr. Emily O'BrienIn this week’s COVID-19 Grand Rounds session, Dr. Emily O’Brien of Duke University will present “HERO-Together: Building Vaccine Confidence With Long-Term Outcomes Data.” The Grand Rounds session will be held on Friday, January 8, at 1:00 pm eastern. Join the online meeting.

HERO-Together is a long-term safety study of the COVID-19 vaccine developed by Pfizer and BioNTech. In the study, the Duke Clinical Research Institute (DCRI) and Verily, with funding from Pfizer, are using the HERO Registry to gain long-term insights about the vaccine by following vaccinated healthcare workers for 2 years to assess their experiences after receiving the vaccine.

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

For previous COVID-19 Grand Rounds, and more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

October 28, 2020: NIH Collaboratory COVID-19 Grand Rounds Continues With the Minnesota Hydroxychloroquine Experience

Posted on by Damon Seils

Photo of Dr. David BoulwareIn this week’s COVID-19 Grand Rounds session, Dr. David Boulware of the University of Minnesota will present “Lessons From Virtual Trials in the Time of a Pandemic: Minnesota Hydroxychloroquine Experience.” The Grand Rounds session will be held on Friday, October 30, at 1:00 pm eastern. Join the online meeting.

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

For previous COVID-19 Grand Rounds, and more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

 

October 21, 2020: PCT Grand Rounds to Feature Implementation Framework for Outpatient Clinical Decision Support

Posted on by Damon Seils

The NIH Collaboratory’s PCT Grand Rounds will highlight an implementation framework for outpatient clinical decision support.

In this week’s session, Drs. Patrick O’Connor and JoAnn Sperl-Hillen of HealthPartners Institute will present “Outpatient Clinical Decision Support – An Evidence-Based Implementation Framework.” The Grand Rounds session will be held on Friday, October 23, at 1:00 pm eastern. Join the online meeting.

Learn more about upcoming and recent Grand Rounds webinars.

October 14, 2020: NIH Collaboratory COVID-19 Grand Rounds Continues With the ABC Science Collaborative

Posted on by Damon Seils

In this week’s COVID-19 Grand Rounds session, Dr. Danny Benjamin of Duke University will present “Back to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative.” The Grand Rounds session will be held on Friday, October 16, at 1:00 pm eastern. Join the online meeting.

The ABC Science Collaborative is a program of the Duke University School of Medicine and the University of North Carolina School of Medicine that “pairs scientists and physicians with school and community leaders to help them understand the most current and relevant data about COVID-19 so they may make decisions that will keep teachers, staff, and children safe if and when they return to the classroom.”

The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency.

Previous COVID-19 Grand Rounds:

For more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

October 9, 2020: Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo) (Myles Wolf, MD)

Posted on by Gina Uhlenbrauck

Speaker

Myles Wolf, MD, MMSc
Division of Nephrology, Department of Medicine
Duke Clinical Research Institute
Duke University School of Medicine

Topic

Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo)

Keywords

End-stage renal disease; Hemodialysis; Serum phosphate; Patient-centered outcomes; NIDDK; Electronic health record; Cluster randomization; eConsent

Key Points

  • High serum phosphate is a ubiquitous complication in end-stage renal disease (ESRD), a serious illness that affects ~500,000 people in the United States. However, evidence is lacking for the best approach to reducing high phosphate that benefits survival in patients.
  • The hemodialysis setting is ideal for conducting a pragmatic trial because of an accessible study population, frequent clinical encounters, granular and uniform data collection via electronic health record (EHR), and the many unanswered questions about major aspects of dialysis care.
  • Pragmatic features of HiLo include:
    • Real-world setting
    • Cluster randomization
    • Broad entry criteria
    • Electronic informed consent
    • No traditional on-site study staff
    • Remote site monitoring
    • Outcomes based on EHR with no adjudication

Discussion Themes

The HiLo Ambassadors, a patient advisory group, have contributed to HiLo study materials including the protocol, informed consent form, eConsent script, informational videos, FAQs, flyer, and website content. They are providing strategies to help patients successfully participate and stay in the trial.

Dieticians are critical to the success of HiLo as they directly interact with dialysis patients and are among the most motivated caregivers on dialysis teams.

The onset of the COVID-19 pandemic came after the first week of HiLo site activation, causing a pause of trial activities and enrollment at the dialysis facilities.

What will success look like for the HiLo trial? A clear, proven answer to the question of higher versus lower target.

Read more about HiLo trial at the study website and the NIH Collaboratory Trials page.

Tags

#pctGR, @Collaboratory1

October 7, 2020: A Year Into Implementation, HiLo Shares an Update and Lessons Learned

Posted on by Damon Seils

Logo for the HiLo NIH Collaboratory TrialThe principal investigator of HiLo, an NIH Collaboratory Trial, will report on the study’s progress in the next session of PCT Grand Rounds on October 9. HiLo is a pragmatic clinical trial of higher vs lower serum phosphate targets in patients undergoing hemodialysis. The project entered the implementation phase last fall.

Dr. Myles Wolfe of Duke University will present “Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo).” The Grand Rounds session will be held on Friday, October 9, at 1:00 pm eastern. Join the online meeting.

HiLo is supported within the NIH Collaboratory by a cooperative agreement from the National Institute of Diabetes and Digestive and Kidney Diseases.

September 30, 2020: PCORI’s Nakela Cook to Offer a Look Ahead in PCT Grand Rounds

Posted on by Damon Seils

Photograph of Dr. Nakela CookDr. Nakela Cook, executive director of the Patient-Centered Outcomes Research Institute (PCORI), will present “Driving Toward Health Impact: Our Journey and Path Forward” during the NIH Collaboratory’s PCT Grand Rounds.

The Grand Rounds session will be held on Friday, October 2, at 1:00 pm eastern. Join the online meeting.

Since 2010, PCORI has funded more than $2 billion in research to help patients, caregivers, and clinicians make informed healthcare decisions and to improve healthcare delivery and outcomes.