Grand Rounds

April 12, 2023: This Week’s PCT Grand Rounds to Provide Updates on RECOVER Long COVID Initiative

Posted on by Damon Seils

Headshot of Dr. Kanecia ZimmermanIn this Friday’s PCT Grand Rounds, Kanecia Zimmerman of Duke University will present “RECOVER in Action: Status of Clinical Trial Protocols.” The Grand Rounds session will be held on Friday, April 14, 2023, at 1:00 pm eastern.

Dr. Zimmerman is an associate professor of pediatrics in the Duke University School of Medicine. The Researching COVID to Enhance Recovery (RECOVER) initiative brings together patients, caregivers, clinicians, and community leaders to conduct large-scale national research studies with the goal of understanding and improving the treatment of long COVID,

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April 5, 2023: This Friday’s PCT Grand Rounds Highlights Applications of Behavioral and Implementation Science in Cardiovascular Medicine

Posted on by Damon Seils

Headshot of Dr. Srinath AdusumalliIn this Friday’s PCT Grand Rounds, Srinath Adusumalli of the University of Pennsylvania will present “A Nudge Towards Cardiovascular Health: Applications of Behavioral and Implementation Science in Cardiovascular Medicine.” The Grand Rounds session will be held on Friday, April 7, 2023, at 1:00 pm eastern.

Dr. Adusumalli is an adjunct assistant professor of medicine and an adjunct professor of healthcare management at the University of Pennsylvania. He is the senior medical director of enterprise virtual care and retail health for CVS Health, where he drives clinical initiatives to support the company’s virtual strategy.

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March 29, 2023: This Friday’s PCT Grand Rounds Features Novel Approach to Lowering Blood Pressure in QUARTET USA Trial

Posted on by Damon Seils

Headshot of Dr. Jody CiolinoIn this Friday’s PCT Grand Rounds, Jody Cioliono will present “Efficacy and Safety of a Quadruple Ultra-Low-Dose Treatment for Hypertension (QUARTET USA): Results From a Randomized Controlled Trial.” The Grand Rounds session will be held on Friday, March 31, 2023, at 1:00 pm eastern.

The QUARTET USA trial tested a novel approach to lowering blood pressure compared with standard-dose monotherapy. The trial was embedded within a network of federally qualified healthcare centers in the Chicago metropolitan area. Ciolino is an associate professor of preventive medicine (biostatistics) and director of the master of science in biostatistics program in the Northwestern University Feinberg School of Medicine.

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March 22, 2023: A Decade of PCORnet Research in This Week’s PCT Grand Rounds

Posted on by Damon Seils

Headshots of Erin Holve, Russell Rothman, Schuyler Jones, and Neha PagidipatiIn this Friday’s PCT Grand Rounds, Erin Holve, Russell Rothman, Schuyler Jones, and Neha Pagidipati will present “From Observational Studies to Pragmatic Clinical Trials: (Almost) A Decade of Research in PCORnet®.” The Grand Rounds session will be held on Friday, March 24, 2023, at 1:00 pm eastern.

Holve is the chief research infrastructure officer for PCORI. Rothman is the principal investigator of the PCORI-funded Mid-South Clinical Data Research Network and a member of the PCORnet Executive Committee. Jones is an associate professor of medicine and population health sciences at Duke University. Pagidipati is an associate professor of medicine at Duke University.

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March 15, 2023: In This Friday’s PCT Grand Rounds, PROs for Adverse Event Monitoring in Oncology

Posted on by Damon Seils

Headshot of Dr. Ethan BaschIn this Friday’s PCT Grand Rounds, Ethan Basch of the University of North Carolina at Chapel Hill will present “Patient-Reported Outcomes for Symptom and Adverse Event Monitoring in Oncology.” The Grand Rounds session will be held on Friday, March 17, 2023, at 1:00 pm eastern.

Basch is the Richard M. Goldberg Distinguished Professor of Medical Oncology in the UNC School of Medicine and a professor of health policy and management in the UNC Gillings School of Global Public Health. He led the National Cancer Institute’s initiative to develop a patient-reported adverse event monitoring system for use in clinical research (the “PRO-CTCAE”), and he is the study chair for multiple trials employing patient-reported endpoints.

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March 8, 2023: Biostatistics Core Sponsors This Week’s PCT Grand Rounds on Estimands in Cluster Randomized Trials

Posted on by Damon Seils

Headshot of Brennan KahanIn this Friday’s PCT Grand Rounds, Brennan Kahan of University College London will present “Estimands in Cluster-Randomized Trials: Choosing Analyses That Answer the Right Question.” This session is sponsored by the NIH Pragmatic Trials Collaboratory’s Biostatistics and Study Design Core Working Group.

The Grand Rounds session will be held on Friday, March 10, 2023, at 1:00 pm eastern.

Kahan is a senior research fellow in the Institute of Clinical Trials and Methodology at University College London.

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March 1, 2023: This Week’s PCT Grand Rounds Highlights Implementation Lessons From GGC4H

Posted on by Damon Seils

Headshots of Margaret Kuklinski and Stacy Sterling with the GGC4H logoIn this Friday’s PCT Grand Rounds, Dr. Margaret Kuklinski and Dr. Stacy Sterling will present “Adoption, Implementation and Sustainment of Family-Focused Prevention in Health Care Systems: How Do We Get There?” Kuklinski and Sterling are the principal investigators of GGC4H, an NIH Pragmatic Trials Collaboratory Trial.

The Grand Rounds session will be held on Friday, March 3, 2023, at 1:00 pm eastern.

Kuklinski is an associate professor of social work and the director of the Social Development Research Group in the University of Washington School of Social Work. Sterling is a senior research scientist in the Kaiser Permanente Division of Research.

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February 22, 2023: In This Week’s PCT Grand Rounds, an Inclusive, Real-World S2302 Pragmatica-Lung

Posted on by Damon Seils

Headshots of Dr. Konstantin Dragnev and Dr. Karen ReckampIn this Friday’s PCT Grand Rounds, Dr. Konstantin Dragnev and Dr. Karen Reckamp will present “S2302 Pragmatica-Lung: New Directions for Decreasing Burden and Increasing Inclusion in NCTN Clinical Trials.”

The Grand Rounds session will be held on Friday, February 24, 2023, at 1:00 pm eastern.

S2302 Pragmatica-Lung is pragmatic clinical trial testing the effect of ramucirumab and pembrolizumab vs standard treatment on overall survival among patients whose non-small-cell lung cancer has advanced after immunotherapy and chemotherapy. The trial is being conducted in the National Cancer Institute’s National Clinical Trials Network of more than 2000 academic and community clinical sites.

Dragnev is a professor of medicine and the Irene Heinz Given Professor in Pharmacology in the Dartmouth Geisel School of Medicine and associate director for clinical research at the Dartmouth Cancer Center. Reckamp is a professor in medicine, director of the Division of Medical Oncology, and associate director of clinical research at Cedars-Sinai Cancer Center.

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February 15, 2023: This Week’s PCT Grand Rounds Will Feature the Heartline Trial of the Apple Watch to Detect Atrial Fibrillation

Posted on by Damon Seils

Headshot of C. Michael GibsonIn this Friday’s PCT Grand Rounds, Dr. C. Michael Gibson of Harvard Medical School will present “The Heartline Trial: A New Paradigm in Conducting Virtual Clinical Trials.”

The Grand Rounds session will be held on Friday, February 17, 2023, at 1:00 pm eastern.

Gibson is a professor of medicine at Harvard Medical School, an interventional cardiologist at Beth Israel Lahey Health, and CEO and president of the nonprofit Baim Institute for Clinical Research and the PERFUSE Study Group. He will discuss the Heartline trial, a virtual randomized controlled trial assessing the effectiveness of the Apple Watch in detecting new-onset atrial fibrillation to reduce stroke, myocardial infarction, and all-cause mortality.

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February 8, 2023: Goals of Informing and Consenting, This Friday in the Ethics and Regulatory Grand Rounds Series

Posted on by Damon Seils

Headshots of Pearl O'Rourke, Dave Wendler, Miguel Vazquez, and Michael HoThis Friday’s PCT Grand Rounds will feature the next installment of our special series, Ethical & Regulatory Dimensions of Pragmatic Clinical Trials. Pearl O’Rourke, Dave Wendler, Miguel Vazquez, and Michael Ho will present “Informing and Consenting: What Are the Goals?”

The Grand Rounds session will be held on Friday, February 10, 2023, at 1:00 pm eastern.

O’Rourke is the director of human research affairs at Partners HealthCare Systems in Boston and an associate professor of pediatrics at Harvard. She serves as cochair of the NIH Collaboratory’s Ethics and Regulatory Core. Wendler is the head of the Section on Research Ethics in the NIH Clinical Center and a member of the Ethics and Regulatory Core. Vazquez is a professor of internal medicine at UT Southwestern Medical Center and the principal investigator of the ICD-Pieces NIH Collaboratory Trial. Ho is a professor medicine at the University of Colorado and the principal investigator of the Nudge NIH Collaboratory Trial.

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This special Grand Rounds series features moderated webinar discussions with panels of experts. The sessions focus on a range of topics, including the ethics of data sharing; ethical and regulatory considerations in the design and conduct of pragmatic trials; pragmatic research involving patients with dementia; and the use of waivers and alterations of consent.

Read the full program.