Grand Rounds

February 1, 2023: This Week in PCT Grand Rounds, Insights From the NITRIC Trial in Young Children

Posted on by Damon Seils

Headshot of Luregn SchlapbachIn this Friday’s PCT Grand Rounds, Professor Luregn Schlapbach of the University Children’s Hospital Zurich will present “Pragmatic Trials for Children With Congenital Heart Disease: Insights From the NITRIC Trial.”

The Grand Rounds session will be held on Friday, February 3, 2023, at 1:00 pm eastern.

Schlapbach is head of intensive care and neonatology at the University Children’s Hospital Zurich and a researcher at the University of Queensland. He will discuss the design and results of the NITRIC trial, which examined the effect of nitric oxide on children undergoing cardiac surgery on cardiopulmonary bypass.

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January 25, 2023: PCT Grand Rounds Features PREPARE II Trial in Critically Ill Adults

Posted on by Damon Seils

Headshots of Dr. Derek Russell and Dr. Matthew SemlerIn this Friday’s PCT Grand Rounds, Dr. Derek Russell of the University of Alabama at Birmingham and Dr. Matthew Semler of Vanderbilt University will present “The PREPARE II Trial: Embedding a Pragmatic Trial Into Clinical Care During an Emergency Procedure.”

The Grand Rounds session will be held on Friday, January 27, 2023, at 1:00 pm eastern.

Russell is an assistant professor of medicine and co-director of the Program in Medical ICU Research at the University of Alabama at Birmingham. Semler is an assistant professor of medicine and biomedical informatics at Vanderbilt University and medical director of the Center for Learning Healthcare in the Vanderbilt Institute for Clinical and Translational Research.

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January 18, 2023: PCT Grand Rounds Will Spotlight the EVOLVE-MI Pragmatic Trial

Posted on by Damon Seils

Headshot of Mikhail KosiborodIn this Friday’s PCT Grand Rounds, Mikhail Kosiborod of the University of Missouri-Kansas City will present “Collaborative Pragmatic Trials in Action: EVOLVE-MI.”

The Grand Rounds session will be held on Friday, January 20, 2023, at 1:00 pm eastern.

Kosiborod is a cardiologist, the vice president of research at Saint Luke’s Health System, and a professor of medicine at the University of Missouri-Kansas City. EVOLVE-MI is a pragmatic clinical trial evaluating the impact of rapid and intensive cholesterol lowering in patients who receive evolocumab within 10 days of a non-ST-elevation myocardial infarction or ST-elevation myocardial infarction.

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January 11, 2023: Ethics and Regulatory Grand Rounds Series Addresses Vulnerable Populations in Pragmatic Trials This Friday

Posted on by Damon Seils

Headshot of Dr. Emily LargentThis Friday’s PCT Grand Rounds will feature the next installment of our special series, Ethical & Regulatory Dimensions of Pragmatic Clinical Trials. Emily Largent will present “Ethical Considerations When Vulnerable Populations are Subjects in Pragmatic Trials.”

The Grand Rounds session will be held on Friday, January 13, 2023, at 1:00 pm eastern.

Dr. Largent is the Emanuel and Robert Hart Assistant Professor of Medical Ethics and Health Policy at the University of Pennsylvania. Her work explores ethical and regulatory aspects of human subjects research as well the social, legal, and ethical considerations that arise when research findings are translated into care.

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This special Grand Rounds series features moderated webinar discussions with panels of experts. The sessions focus on a range of topics, including the ethics of data sharing; ethical and regulatory considerations in the design and conduct of pragmatic trials; pragmatic research involving patients with dementia; and the use of waivers and alterations of consent.

Read the full program.

January 4, 2023: This Week’s COVID-19 Grand Rounds Will Share Long COVID Outcome Data From the COVID-OUT Trial

Posted on by Damon Seils

Headshots of Dr. Carolyn Bramante and Dr. Thomas MurrayIn this Friday’s COVID-19 Grand Rounds, Dr. Carolyn Bramante and Dr. Thomas Murray of the University of Minnesota will present “Outpatient Treatment of COVID-19 With Metformin, Ivermectin, or Fluvoxamine: 10-Month Follow-up and Effects on Developing Long COVID.”

The Grand Rounds session will be held on Friday, January 6, at 1:00 pm eastern. Join the online meeting.

The NIH Pragmatic Trials Collaboratory Coordinating Center is using its popular Grand Rounds platform to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency. For previous COVID-19 Grand Rounds, and more news and resources related to the COVID-19 public health emergency, see the COVID-19 Resources page.

December 14, 2022: This Friday’s PCT Grand Rounds Highlights EHR-Based Clinical Decision Support for Prevention of Thromboembolism

Posted on by Damon Seils

Head shots for Alex C. Spyropoulos and Jeffrey SolomonIn this Friday’s PCT Grand Rounds, Alex Spyropoulos and Jeffrey Solomon of the Feinstein Institutes for Medical Research will present “The Use of EHR-Agnostic Clinical Decision Support to Prevent Thromboembolism in Hospitalized Medically Ill Patients.”

The Grand Rounds session will be held on Friday, December 16, 2022, at 1:00 pm eastern.

Spyropoulos is a professor of medicine in the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, a professor in the Institute of Health System Science at the Feinstein Institutes for Medical Research, and the system director for anticoagulation and clinical thrombosis services for Northwell Health at Lenox Hill Hospital. Solomon is senior director of the Usability Lab at the Feinstein Institutes for Medical Research.

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December 7, 2022: Ethics and Regulatory Grand Rounds Series Explores Stepped-Wedge Designs This Friday

Posted on by Damon Seils

Headshots of Monica Taljaard and David MagnusThis Friday’s PCT Grand Rounds will feature the next installment of our special series, Ethical & Regulatory Dimensions of Pragmatic Clinical Trials. Monica Taljaard and David Magnus will present “The Stepped Wedge Cluster Randomized Trial: Friend or Foe?”

The Grand Rounds session will be held on Friday, December 9, 2022, at 1:00 pm eastern.

Taljaard is a senior scientist in the Clinical Epidemiology Program at the Ottawa Hospital Research Institute and a professor of epidemiology and community medicine at the University of Ottawa. Magnus is the director of the Stanford Center for Biomedical Ethics and the Thomas A. Raffin Professor of Medicine and Biomedical Ethics and associate dean for research at the Stanford University School of Medicine.

Join the online meeting.

This special Grand Rounds series features moderated webinar discussions with panels of experts. The sessions focus on a range of topics, including the ethics of data sharing; ethical and regulatory considerations in the design and conduct of pragmatic trials; pragmatic research involving patients with dementia; and the use of waivers and alterations of consent.

Read the full program.

November 30, 2022: This Week in PCT Grand Rounds, a Pragmatic Trial of an mHealth Intervention for Heart Failure and Diabetes

Posted on by Damon Seils

Headshot of Dr. Michael FelkerIn this Friday’s PCT Grand Rounds, Dr. Michael Felker of Duke University will present “A Randomized Controlled Trial of a Mobile Health Intervention in Heart Failure and Diabetes: Lessons Learned.” The Grand Rounds session will be held on Friday, November 18, 2022, at 1:00 pm eastern.

Felker is a professor of medicine in the Duke University School of Medicine and the director of cardiovascular and metabolism research at the Duke Clinical Research Institute. Dr. Felker will discuss TARGET-HF-DM, a pragmatic trial that tested the effectiveness of a mobile health intervention to improve physical activity and medication adherence among patients with heart failure and diabetes mellitus.

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November 16, 2022: FIRST-ABC Pragmatic Trials Are Focus of This Week’s PCT Grand Rounds

Posted on by Damon Seils

Headshot of Padmanabhan RamnarayanIn this Friday’s PCT Grand Rounds, Dr. Padmanabhan Ramnarayan of Imperial College London will present “The FIRST-ABC Pragmatic Trials of Non-Invasive Respiratory Support in Children.” The Grand Rounds session will be held on Friday, November 18, 2022, at 1:00 pm eastern.

Ramnarayan is a reader in pediatric critical care at Imperial College London. FIRST-ABC is a master protocol combining 2 pragmatic noninferiority randomized controlled trials evaluating high-flow nasal oxygen and continuous positive airway pressure in children with respiratory failure.

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November 9, 2022: Ethics and Regulatory Grand Rounds Series Continues This Friday

Posted on by Damon Seils

Headshots of Stephanie Morain and Kayte Spector-BagdadyThis Friday’s PCT Grand Rounds will feature the next installment of our special series, Ethical & Regulatory Dimensions of Pragmatic Clinical Trials. Stephanie Morain and Kayte Spector-Bagdady will present “Data Sharing and Pragmatic Clinical Trials: Law and Ethics Amidst a Changing Policy Landscape.”

The Grand Rounds session will be held on Friday, November 11, 2022, at 1:00 pm eastern.

Morain is a core faculty member in the Berman Institute of Bioethics and an assistant professor of health policy and management in the Bloomberg School of Public Health, both at Johns Hopkins University. Spector-Bagdady is interim codirector of the Center for Bioethics and Social Sciences in Medicine and an assistant professor of obstetrics and gynecology at the University of Michigan Medical School. Both Morain and Spector-Bagdady are members of the NIH Collaboratory’s Ethics and Regulatory Core.

Join the online meeting.

This special Grand Rounds series features moderated webinar discussions with panels of experts. The sessions focus on a range of topics, including the ethics of data sharing; ethical and regulatory considerations in the design and conduct of pragmatic trials; pragmatic research involving patients with dementia; and the use of waivers and alterations of consent.

Read the full program.