December 13, 2023: In This Week’s PCT Grand Rounds, a Path Forward for Diversifying Clinical Trials

In this Friday's PCT Grand Rounds, Roxana Mehran of the Icahn School of Medicine at Mount Sinai will present "Diversifying Clinical Trials: A Path Forward."

The Grand Rounds session will be held on Friday, December 15, 2023, at 1:00 pm eastern.

Mehran is a professor of medicine and the director of interventional cardiovascular research and clinical trials at the Zena and Michael A. Wiener Cardiovascular Institute at the Mount Sinai School of Medicine.

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December 6, 2023: Jumpstarting Communication About Goals of Care, in This Week’s PCT Grand Rounds

Headshots of Drs. Ruth Engelberg, Erin Kross, and Robert LeeIn this Friday's PCT Grand Rounds, Ruth Engelberg, Erin Kross, and Robert Lee of the University of Washington will present "A Pragmatic Randomized Trial of the Jumpstart Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness."

The Grand Rounds session will be held on Friday, December 8, 2023, at 1:00 pm eastern.

Engelberg is a research professor of medicine, Kross is an associate professor of medicine, and Lee is an assistant professor of medicine in pulmonary, critical care, and sleep medicine at the University of Washington.

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November 29, 2023: Special Biostatistics Series Continues With Guidelines for Stepped-Wedge Trials

In this Friday’s PCT Grand Rounds, Jim Hughes of the University of Washington will continue our special series, Advances in the Design and Analysis of Pragmatic Clinical Trials, with his presentation, “Guidelines for Design and Analysis of Stepped-Wedge Trials.” The session will be held on Friday, December 1, at 1:00 pm eastern.

Hughes is a professor emeritus of biostatistics at the University of Washington. This session’s moderator, Patrick Heagerty, is a professor of biostatistics at the University of Washington and a cochair of the NIH Pragmatic Trials Collaboratory’s Biostatistics and Study Design Core.

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This special Grand Rounds series will include additional moderated webinar discussions that bring together biostatisticians, clinical trials methodologists, and investigators to discuss challenges and share lessons learned in the design, implementation, and analysis of pragmatic trials. Download the series flyer and see the full schedule below.

All sessions are free and open to the public; no registration is required.

November 15, 2023: In This Friday’s PCT Grand Rounds, Results From the Nudge NIH Collaboratory Trial

In this Friday's PCT Grand Rounds, Michael Ho and Sheana Bull of the University of Colorado will present "Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results From the Nudge Study."

The Grand Rounds session will be held on Friday, November 17, 2023, at 1:00 pm eastern.

Nudge is an NIH Collaboratory Trial. Ho is a professor of medicine and Bull is a professor of community and behavioral health at the University of Colorado. They are the co–principal investigators of Nudge.

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November 1, 2023: Special Biostatistics Series Continues With Complex Clustering in Pragmatic Trials

In this Friday’s PCT Grand Rounds, Jonathan Moyer of the NIH Office of Disease Prevention will continue our special series, Advances in the Design and Analysis of Pragmatic Clinical Trials, with his presentation, “The Perils and Pitfalls of Complex Clustering in Pragmatic Trials.” The session will be held on Friday, November 3, at 1:00 pm eastern and will be moderated by Andrea Cook.

Moyer is a statistician in the NIH Office of Disease Prevention. He is a longtime member of the NIH Pragmatic Trials Collaboratory’s Biostatistics and Study Design Core. This session’s moderator, Andrea Cook, is a senior biostatistics investigator in the Kaiser Permanente Washington Health Research Institute.

Join the online meeting.

This special Grand Rounds series will include additional moderated webinar discussions that bring together biostatisticians, clinical trials methodologists, and investigators to discuss challenges and share lessons learned in the design, implementation, and analysis of pragmatic trials. Download the series flyer and see the full schedule below.

All sessions are free and open to the public; no registration is required.

October 25, 2023: In This Friday’s PCT Grand Rounds, Krumholz Presents PaxLC Trial of Paxlovid for Long COVID

Banner showing a headshot of Dr. Harlan Krumholz and the title of his upcoming PCT Grand Rounds Session, "Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial."In this Friday’s PCT Grand Rounds, Harlan Krumholz of Yale University will present “Digital, Decentralized and Democratized: Lessons From the Yale PaxLC Trial.”

The Grand Rounds session will be held on Friday, October 27, 2023, at 1:00 pm eastern.

The PaxLC Trial is a decentralized study of Paxlovid in adult participants with long COVID. Krumholz, the principal investigator for the trial, is the Harold H. Hines, Jr Professor of Medicine at Yale University and the director of the Yale-New Haven Hospital Center for Outcomes Research and Evaluation.

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October 18, 2023: In This Friday’s PCT Grand Rounds, Ending Hepatitis C in the United States

Headshots of Rachael Fleurence and Joshua SharfsteinIn this Friday’s PCT Grand Rounds, Rachael Fleurence of the NIH and Joshua Sharfstein of Johns Hopkins University will present “A National Initiative to Eliminate Hepatitis C in the United States – Why This Matters to Clinical Trialists.”

The Grand Rounds session will be held on Friday, October 20, 2023, at 1:00 pm eastern.

Fleurence is a senior advisor at the NIH. Sharfstein is a professor of the practice in health policy and management and the vice dean for public health practice and community engagement in the Johns Hopkins Bloomberg School of Public Health and director of the Bloomberg American Health Initiative.

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October 11, 2023: In This Friday’s PCT Grand Rounds, Incorporating Social Determinants of Health Into PCORnet

Headshot of Dr. Keith Marsolo
Keith Marsolo, PhD

In this Friday’s PCT Grand Rounds, Keith Marsolo of Duke University will present “Incorporating Social Determinants of Health Into PCORnet.”

The Grand Rounds session will be held on Friday, October 13, 2023, at 1:00 pm eastern.

Marsolo is an associate professor of population health sciences at Duke University and a cochair of the NIH Pragmatic Trials Collaboratory’s Electronic Health Records Core Working Group.

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October 4, 2023: Special Biostatistics Grand Rounds Series Begins Friday With Rigorous Methods for Hybrid Studies

In this Friday’s PCT Grand Rounds, David Murray of the NIH Office of Disease Prevention will kick off our special series, Advances in the Design and Analysis of Pragmatic Clinical Trials, with his presentation, “Hybrid Studies Should Not Sacrifice Rigorous Methods.” The session will be held on Friday, October 6, at 1:00 pm eastern and will be moderated by Jonathan Moyer.

Murray is the NIH associate director for prevention and the director of the Office of Disease Prevention. He is a longtime member of the NIH Pragmatic Trials Collaboratory’s Biostatistics and Study Design Core. This session’s moderator, Jon Moyer, is a statistician in the Office of Disease Prevention.

Join the online meeting.

This special Grand Rounds series will include additional moderated webinar discussions that bring together biostatisticians, clinical trials methodologists, and investigators to discuss challenges and share lessons learned in the design, implementation, and analysis of pragmatic trials. Download the series flyer and see the full schedule below.

All sessions are free and open to the public; no registration is required.

September 27, 2023: This Friday’s PCT Grand Rounds to Highlight PROTEUS Consortium

Headshots of Claire Snyder, Norah Crossnohere, and Anne SchusterIn this Friday’s PCT Grand Rounds, Claire Snyder of Johns Hopkins University and Norah Crossnohere and Anne Schuster, both of Ohio State University, will present “Navigating the Use of Patient-Reported Outcomes in Research and Practice: The PROTEUS Consortium.”

The Grand Rounds session will be held on Friday, September 29, 2023, at 1:00 pm eastern.

The PROTEUS Consortium provides tools and resources to assist researchers in the the use of patient-reported outcomes in clinical trials and clinical practice.

Snyder is a professor of medicine and the director of the Program for Building Lifestyle, Outcomes, and Care Services Research in Cancer (BLOCS) at Johns Hopkins University. Crossnohere is an assistant professor of medicine and Schuster is a research scientist at Ohio State University.

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