Grand Rounds

February 28, 2024: A Randomized Trial of a Food-as-Medicine Program, in This Week’s PCT Grand Rounds

Posted on by Damon Seils

In this Friday’s PCT Grand Rounds, Joseph Doyle of the Massachusetts Institute of Technology (MIT) will present “Effect of an Intensive Food-as-Medicine Program on Health and Healthcare Use: Evidence From a Randomized Clinical Trial.”

The Grand Rounds session will be held on Friday, March 1, 2024, at 1:00 pm eastern.

Doyle is the Erwin H. Schell Professor of Management and Applied Economics at the MIT Sloan School of Management. His healthcare research includes partnering with large healthcare systems to conduct randomized trials of changes in the ways healthcare is delivered.

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February 21, 2024: In This Week’s PCT Grand Rounds, Virtual Monitoring in Decentralized Clinical Trials

Posted on by Damon Seils

In this Friday’s PCT Grand Rounds, Adrian Hernandez and Christopher Lindsell of Duke University will present “Virtual Vigilance: Monitoring of Decentralized Clinical Trials.”

The Grand Rounds session will be held on Friday, February 23, 2024, at 1:00 pm eastern.

Hernandez is the executive director of the Duke Clinical Research Institute (DCRI) and professor of medicine and vice dean in the Duke University School of Medicine. He also serves as co-principal investigator of the NIH Pragmatic Trials Collaboratory Coordinating Center. Lindsell is the director of data science and biostatistics at the DCRI and professor and cochief of biostatistics in the Department of Biostatistics and Bioinformatics in the Duke University School of Medicine.

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February 19, 2024: Virtual Monitoring in Decentralized Trials, in This Week’s PCT Grand Rounds

Posted on by Damon Seils

In this Friday’s PCT Grand Rounds, Adrian Hernandez and Christopher Lindsell of Duke University will present “Virtual Vigilance: Monitoring of Decentralized Clinical Trials.”

The Grand Rounds session will be held on Friday, February 23, 2024, at 1:00 pm eastern.

Hernandez is the executive director of the Duke Clinical Research Institute (DCRI) and professor of medicine and vice dean in the Duke University School of Medicine. He also serves as co-principal investigator of the NIH Pragmatic Trials Collaboratory Coordinating Center. Lindsell is the director of data science and biostatistics at the DCRI and professor and cochief of biostatistics in the Department of Biostatistics and Bioinformatics in the Duke University School of Medicine.

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February 14, 2024: In This Friday’s PCT Grand Rounds, Clinical Implications of the MINT Trial

Posted on by Damon Seils
Dr. Jeffrey Carson

In this Friday’s PCT Grand Rounds, Jeffrey Carson of Rutgers Biomedical and Health Sciences will present “Clinical Implications of the MINT Trial: p=0.07.”

The Grand Rounds session will be held on Friday, February 16, 2024, at 1:00 pm eastern.

Carson is provost-New Brunswick for Rutgers Biomedical and Health Sciences and the Distinguished Professor of Medicine and Richard C. Reynolds, MD, Chair in General Internal Medicine at Rutgers Robert Wood Johnson Medical School.

Carson will discuss the clinical implications of the Myocardial Ischemia and Transfusion (MINT) trial, a pragmatic clinical trial that did not show a significant difference between the study arms in the primary outcome yet consistently favored one intervention strategy in the point estimates for the primary and secondary outcomes.

The goal of the MINT trial was to determine whether the risk of recurrent myocardial infarction or death at 30 days differed between a restrictive transfusion strategy and a liberal transfusion strategy among patients with an acute myocardial infarction and anemia. The pragmatic trial’s broad inclusion criteria resulted in a study population with a variety of diagnoses and coexisting illnesses that was generally representative of patients in clinical practice. The trial’s transfusion protocols approximated clinical practice in a variety of healthcare settings.

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February 7, 2024: Pragmatic Recruitment of Underrepresented Groups, in This Week’s PCT Grand Rounds

Posted on by Damon Seils

In this Friday’s PCT Grand Rounds, Cynthia Hau of the VA Boston Health Care System will present “Pragmatic Recruitment of Underrepresented Groups: Experience From the Diuretic Comparison Project.”

The Grand Rounds session will be held on Friday, February 9, 2024, at 1:00 pm eastern.

Hau is a statistician for the VA Cooperative Studies Program Coordinating Center in the VA Boston Health Care System. Hau recently led a secondary analysis of the Diuretic Comparison Project presenting a centralized electronic health record–based model for the recruitment of participants from underrepresented groups.

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January 31, 2024: Improving the Public’s Understanding of the FDA, in This Week’s PCT Grand Rounds

Posted on by Damon Seils

In this Friday's PCT Grand Rounds, Susan Winckler of the Reagan-Udall Foundation for the FDA will present "Strategies for Improving Public Understanding of FDA and the Products It Regulates: Why Should We Care, and What Might We Do?"

The Grand Rounds session will be held on Friday, February 2, 2024, at 1:00 pm eastern.

Winckler is the chief executive officer of the Reagan-Udall Foundation for the FDA, a nonprofit organization created by Congress “to advance the mission of the FDA to modernize medical, veterinary, food, food ingredient, and cosmetic product development, accelerate innovation, and enhance product safety.”

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January 24, 2024: In This Friday’s PCT Grand Rounds, Healthcare AI That’s Safe, Effective, and Equitable

Posted on by Damon Seils

Suresh Balu and Mark Sendak

In this Friday's PCT Grand Rounds, Suresh Balu and Mark Sendak of Duke University will present "Advancing the Safe, Effective, and Equitable Use of AI in Healthcare."

The Grand Rounds session will be held on Friday, January 26, 2024, at 1:00 pm eastern.

Balu is the director of the Duke Institute for Health Innovation (DIHI) and the associate dean for innovation and partnership in the Duke University School of Medicine. Sendak is the population health and data science lead at DIHI.

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January 17, 2024: In This Friday’s PCT Grand Rounds, Why Are Imaging Trials Different?

Posted on by Damon Seils

Dr. Pamela Douglas (Photo: Erin Roth, Duke Health)

In this Friday's PCT Grand Rounds, Pamela Douglas of Duke University will present "Why Are Imaging RCTs Different? Lessons From Chest Pain Evaluation Trials."

The Grand Rounds session will be held on Friday, January 19, 2024, at 1:00 pm eastern.

Douglas is the Ursula Geller Professor of Research in Cardiovascular Diseases at Duke University and a past president of both the American College of Cardiology and the American Society of Echocardiography.

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January 10, 2024: In This Friday’s PCT Grand Rounds, a Lottery for Allocating Scarce COVID-19 Resources

Posted on by Damon Seils

In this Friday's PCT Grand Rounds, Erin McCreary of the University of Pittsburgh will present "Design and Implementation of a Weighted Lottery to Equitably Allocate Scarce COVID-19 Resources."

The Grand Rounds session will be held on Friday, January 12, 2024, at 1:00 pm eastern.

McCreary is a clinical assistant professor of medicine at the University of Pittsburgh and the director of infectious diseases improvement and clinical research innovation at UPMC. She is also the president-elect of the Society of Infectious Diseases Pharmacists.

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January 3, 2024: Special Biostatistics Series Concludes With Missing Data in Cluster Randomized Trials

Posted on by Damon Seils

In this Friday's PCT Grand Rounds, Rui Wang of Harvard Medical School will offer the final session in our special series, Advances in the Design and Analysis of Pragmatic Clinical Trials, with "Methods for Handling Missing Data in Cluster Randomized Trials." The session will be held on Friday, January 5, at 1:00 pm eastern.

Wang is an associate professor of population medicine and the director of the Division of Biostatistics in the Department of Population Medicine at Harvard Medical School and the Harvard Pilgrim Health Care Institute. She is also an associate professor in the Department of Biostatistics at the Harvard T.H. Chan School of Public Health. She is a longtime member of the NIH Pragmatic Trials Collaboratory's Biostatistics and Study Design Core Working Group.

This session's moderator, Fan Li, is an assistant professor of biostatistics at the Yale School of Public Health.

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This special Grand Rounds series includes moderated webinar discussions that bring together biostatisticians, clinical trials methodologists, and investigators to discuss challenges and share lessons learned in the design, implementation, and analysis of pragmatic trials. Download the series flyer and see the full schedule below, including archived webinar recordings and slides from previous sessions.

All sessions are free and open to the public. No registration is required.