Funding Opportunity Announcement Archives - Rethinking Clinical Trials

January 2, 2024: NINR Announces Funding Opportunity to Address Social Needs Through Healthcare-Community Partnerships

Posted on January 2, 2024January 3, 2024 by Damon Seils

The National Institute of Nursing Research (NINR) has published a funding opportunity for research to develop and expand interventions and programs that leverage existing or create new healthcare-community partnerships to address unmet social needs among individuals and families and adverse social determinants of health within communities—especially in populations that experience health disparities.

Read the full announcement for more information about the funding opportunity and details on eligibility, research objectives, key dates, application review, and award administration.

Letter of intent due date: February 21, 2024
Application due date: March 22, 2024

NINR will hold a pre-application webinar for prospective applicants on February 15, 2024, from 1:00 to 2:00 pm ET. NIH staff will provide an overview of the funding opportunity and answer questions from potential applicants. Registration is required.

November 27, 2023: NIH Announces Funding Opportunity for Implementation Studies of Substance Use Treatment and Prevention in Populations That Experience Health Disparities

Posted on November 27, 2023 by Damon Seils

The National Institutes of Health’s Office of Disease Prevention (ODP) issued a new funding opportunity to support implementation studies in treatment and prevention for alcohol, tobacco, and other drugs use and misuse in adult populations that experience health disparities.

ODP and participating NIH Institutes and Centers are inviting applications for research projects that test innovative approaches to implementing screening, brief intervention, and referral to treatment or prevention for alcohol, tobacco, and other drugs use and misuse. This R01 funding opportunity will support clinical trial research that develops and prospectively tests implementation strategies that overcome barriers to prevention and treatment in diverse settings. Applicants are strongly encouraged to include in their proposals robust engagement with relevant healthcare and community partners and to examine organizational and system contexts.

The first receipt date for new applications is February 5, 2024.

Read the full funding opportunity.

July 31, 2023: NIH Announces Funding Opportunity for Pain Management Collaboratory Pragmatic Trials

Posted on July 31, 2023 by Damon Seils

The NIH this month published notice of a funding opportunity to support the next round of pragmatic clinical trials within the NIH-DoD-VA Pain Management Collaboratory (PMC).

Read the full notice of funding opportunity (RFA-AT-24-004).

The PMC was established in 2017 with an initial cohort of 11 pragmatic trials. The new funding opportunity leverages the experience, expertise, and leadership of the PMC Coordinating Center with a new round of pragmatic trials evaluating nonpharmacologic solutions to address pain and comorbid conditions in veterans, United States Armed Forces service members, and their families.

The NIH Institutes participating in this funding opportunity include the National Center for Complementary and Integrative Health (NCCIH) and the National Institute of Nursing Research (NINR). Applications may be cofunded by the Office of Disease Prevention (ODP) and the Office of Behavioral and Social Sciences Research (OBSSR).

Learn more about the PMC.

August 11, 2022: New Funding Opportunities From NIH HEAL Initiative Will Support Sickle Cell Disease Pain Management

Posted on August 11, 2022August 31, 2022 by Damon Seils

NIH Heal Initiative logo The Helping to End Addiction Long-Term Initiative℠, or NIH HEAL Initiative℠, recently published 2 funding opportunity announcements soliciting applications focused on sickle cell disease (SCD) pain management. The effort is co-led by the National Center for Complementary and Integrative Health and the National Heart, Lung, and Blood Institute, with support from other NIH Institutes, Centers, and Offices.

RFA-AT-23-001, “HEAL Initiative: Pragmatic and Implementation Studies for the Management of Sickle Cell Disease Pain” (UG3/UH3, Clinical Trials Optional) will support multisite embedded pragmatic or implementation trials to inform the uptake of pharmacologic, nonpharmacologic, and/or multicomponent approaches for acute and/or chronic SCD pain management in healthcare systems that serve the SCD population.
RFA-AT-23-002, “HEAL Initiative: Sickle Cell Disease Pain Management Trials Utilizing the Pain Management Effectiveness Research Network Cooperative Agreement” (UG3/UH3, Clinical Trial Required), will support multisite effectiveness clinical trials of pharmacologic, nonpharmacologic, and/or multicomponent approaches for acute and/or chronic SCD pain management, allowing continued opioid pain management as needed.

August 9, 2022: NIH HEAL Initiative Announces Funding Opportunity for Prevention Research in Community Health Centers

Posted on August 9, 2022August 31, 2022 by Damon Seils

NIH Heal Initiative logo The Helping to End Addiction Long-Term Initiative℠, or NIH HEAL Initiative℠, is seeking applications for opioid misuse prevention research in community health centers.

The funding opportunity announcement, RFA-DA-23-048: HEAL Initiative: Research Studies to Develop and Implement Interventions to Prevent Opioid Misuse in Community Health Centers, supports interdisciplinary teams to study the development, adaptation, and/or implementation of interventions to prevent misuse of opioids and other substances. Research will be supported through exploratory/developmental phase awards that may not exceed 5 years, allocating up to 2 years of funding for development of the project and up to 4 years for a full test of the research aims. Applications are due November 8, 2022.

The National Institute on Drug Abuse will hold a webinar on September 6 for potential applicants. Register for the webinar. For more information, contact Sarah Steverman at sarah.steverman@nih.gov.

March 17, 2022: NIH Will Fund New NIH Collaboratory Trials That Address Health Disparities

Posted on March 17, 2022January 16, 2024 by Damon Seils

Promotional banner for funding opportunity announcement The NIH released a request for applications (RFA) for new NIH Pragmatic Trials Collaboratory Trial grants that address health disparities. NIH program and review staff will discuss the funding opportunity in an upcoming webinar. Registration for the webinar is required.

The RFA for this funding opportunity encourages applications that focus on improving health outcomes in populations that experience health disparities, such as higher rates of disease or mortality compared with the general population. Applications are due June 17, 2022. Letters of intent are due 30 days prior (May 17, 2022).

For the purposes of this funding opportunity, the NIH-designated U.S. health disparity populations definition includes: Blacks/African Americans, Hispanics/ Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities.

Similar to the NIH Pragmatic Trials Collaboratory’s other NIH Collaboratory Trials, the new projects will have a planning and implementation phase and will be large-scale pragmatic or implementation trials that are embedded in healthcare delivery systems. The overarching goal of the projects is to improve care delivery and health outcomes across the lifespan.

Read our Living Textbook chapter about how to develop a compelling grant application for a pragmatic clinical trial.

October 19, 2021: NIH Issues RFA for New NIH Collaboratory Trials That Address Health Disparities

Posted on October 19, 2021January 16, 2024 by Karen Staman

The NIH recently released a request for applications (RFA) for new NIH Collaboratory Trial grants. The RFA encourages applications that focus on improving health outcomes in populations that experience health disparities, such as higher rates of disease or mortality compared with the general population. These populations may be defined by race, ethnicity, geography, or socioeconomic status.

Applications are due December 15, 2021. Letters of intent are due 30 days prior (November 15, 2021).

For the purposes of this funding opportunity, the NIH-designated U.S. health disparity populations definition includes: Blacks/African Americans, Hispanics/ Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities.

Similar to the NIH Collaboratory’s other NIH Collaboratory Trials, the new projects will have a planning and implementation phase and will be large-scale pragmatic or implementation trials that are embedded in healthcare delivery systems. The overarching goal of the projects is to improve care delivery and health outcomes in Americans across the lifespan.

Read the full request for applications.

Read our Living Textbook chapter about how to develop a compelling grant application for a pragmatic clinical trial.

February 10, 2021: New Funding Opportunities Support Investigators at All Levels in Advancing Pragmatic Clinical Research

Posted on February 10, 2021January 17, 2024 by Damon Seils

The NIA IMPACT Collaboratory has announced 3 new funding opportunities for researchers at all levels who are interested in pragmatic clinical trials embedded in healthcare systems (ePCTs). They include funding for NIH Collaboratory Trials, a new scholars program for junior and senior investigators, and a new cycle of funding for 1-year pilot studies.

NIH Collaboratory Trials Program: The IMPACT Collaboratory will fund up to 2 NIH Collaboratory Trials designed as full-scale ePCTs that test nonpharmacological interventions for people living with Alzheimer disease and related dementias (ADRD) and their care partners. The projects should generate evidence on effective care delivery practices that can be expanded or implemented in other healthcare systems. An informational webinar will be held on Thursday, February 11, at 2:00 pm ET.
Health Care System Scholars Program – A new Health Care Systems Embedded Research Scholars Program offers junior and senior investigators an opportunity to work directly with healthcare systems interested in improving the care provided to people living with dementia and their care partners. A informational webinar will be held on Thursday, February 11, at 1:00 pm ET.
Pilot Grants Program: One-year pilot studies are meant to generate preliminary data necessary to design and conduct future full-scale ePCTs. The IMPACT Collaboratory will consider applications for pilot studies that test nonpharmacological interventions embedded in healthcare system for people living with ADRD and their care partners. An informational webinar will be held on Monday, February 22, at 4:00 pm ET.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging. Its mission is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

January 21, 2021: NIA IMPACT Collaboratory to Issue New Funding Opportunity for Pragmatic Trials

Posted on January 21, 2021January 17, 2024 by Damon Seils

The NIA IMPACT Collaboratory has announced that it will publish a request for applications for large-scale pragmatic clinical trials embedded in healthcare systems to test the effectiveness of care delivery intervention programs for people living with Alzheimer disease and related dementias and/or their care partners. The funding opportunity is expected to be announced in February.

More information from the notice of intent:

Under this mechanism, interventions must be linked to the needs of a health care system and powered to detect a significant difference in the primary outcome between trial arms. The goal of the NIH Collaboratory Trials is to generate evidence on effective care delivery practices that can be expanded and/or implemented in other systems.

The IMPACT Collaboratory will give preference to applications for NIH Collaboratory Trials that address dementia care for populations traditionally marginalized or underrepresented in clinical trials and those that promote health equity. It is anticipated that NIH Collaboratory Trials will be funded for up to $500,000 in direct costs for a maximum of 24-months.

The RFA is expected to be published in February 2021. Stay tuned for updates regarding the release of the RFA, an informational webinar and application deadline. If you have questions related to this funding opportunity, please contact IMPACTcollaboratory@hsl.harvard.edu. We will share additional details as they become available on the website at www.IMPACTcollaboratory.org.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging. Its mission is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

December 8, 2020: PCORI to Issue Funding Announcement for Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes

Posted on December 8, 2020December 14, 2020 by Damon Seils

The Patient-Centered Outcomes Research Institute (PCORI) will issue a funding announcement in January for pragmatic clinical studies to evaluate patient-centered outcomes. A total of $90 million will be available in the funding cycle to support individual awards of up to $10 million in direct costs with a maximum project duration of 5 years.

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