The Centers for Medicare and Medicaid Services (CMS), through its Innovation Center, announced a funding opportunity for its new MAHA ELEVATE model, which is designed to test evidence-based, whole-person functional or lifestyle medicine approaches to care.
The model will provide approximately $100 million to fund 3-year cooperative agreements for up to 30 proposals that promote health and prevention for Original Medicare beneficiaries. The proposals will utilize evidence-based, whole-person care approaches — including functional or lifestyle medicine interventions — currently not covered by Original Medicare. These approaches are intended to support, not replace, the medical care received by people with Medicare. MAHA ELEVATE will also gather and evaluate new data on cost and quality to inform future interventions promoting healthy lifestyle behaviors and ultimately reduce spending in Original Medicare. The first cohort of this voluntary model will launch October 2026.
Interventions tested through the model will inform future Medicare coverage determinations and CMS Innovation Center models designed to improve the health of beneficiaries and reduce healthcare costs.
CMS will select recipients based on 5 key criteria:
- Whole-person functional or lifestyle medicine intervention design, including cost savings
- Beneficiary recruitment and study design
- Organizational and administrative capacity
- Data management capabilities
- Budget
Applicants should demonstrate strong, evidence-based support for the proposed intervention and a successful history of implementation of the intervention and cost savings, and the ability to recruit large numbers of participants with a clear randomization plan and advanced data management capabilities.
The notice of funding opportunity is available at https://grants.gov/search-results-detail/361494. Applicants must submit a letter of intent by April 10, 2026. The application deadline is May 15, 2026.
The NIH this month published notice of a funding opportunity to support the next round of pragmatic clinical trials within the NIH-DoD-VA Pain Management Collaboratory (PMC).
The Helping to End Addiction Long-Term Initiative℠, or NIH HEAL Initiative℠, recently published 2 funding opportunity announcements soliciting applications focused on sickle cell disease (SCD) pain management. The effort is co-led by the National Center for Complementary and Integrative Health and the National Heart, Lung, and Blood Institute, with support from other NIH Institutes, Centers, and Offices.
The NIH released a request for applications (RFA) for new NIH Pragmatic Trials Collaboratory Trial grants that address health disparities. NIH program and review staff will discuss the funding opportunity in an upcoming webinar. 
The NIH recently released a request for applications (RFA) for new NIH Collaboratory Trial grants. The RFA encourages applications that focus on improving health outcomes in populations that experience health disparities, such as higher rates of disease or mortality compared with the general population. These populations may be defined by race, ethnicity, geography, or socioeconomic status.
The NIA IMPACT Collaboratory has announced 3 new funding opportunities for researchers at all levels who are interested in pragmatic clinical trials embedded in healthcare systems (ePCTs). They include funding for NIH Collaboratory Trials, a new scholars program for junior and senior investigators, and a new cycle of funding for 1-year pilot studies.