RFA

September 13, 2022: IMPACT Collaboratory Extends Deadline for NIH Collaboratory Trial Letters of Intent

Posted on by Damon Seils

Logo for the NIA IMPACT CollaboratoryThe deadline to submit letters of intent for the NIA IMPACT NIH Collaboratory Trials Program has been extended to September 30, 2022.

This summer, the IMPACT Collaboratory announced a request for applications for its NIH Collaboratory Trials Program.  This funding mechanism supports large-scale pragmatic clinical trials embedded in healthcare systems to test the effectiveness of nonpharmacological interventions for people living with Alzheimer disease and related dementias and their care partners. The interventions will typically encompass relatively simple system changes or direct patient outreach, or successfully piloted programs ready for testing at scale. Awards are for $500,000 in direct costs for 18 months.

Prospective applicants should email their 1-page letter of intent describing their proposed NIH Collaboratory Trial to IMPACTcollaboratory@hsl.harvard.edu. This information will help determine whether the proposed project aligns with the goals of the request for applications prior to a full application. The goal of these NIH Collaboratory Trials is to generate evidence on effective care delivery practices that can be expanded and/or implemented in other systems.

An informational webinar about the program is available.

More than 5 million Americans are living with Alzheimer disease and related dementias. They are particularly vulnerable to receiving uncoordinated and poor-quality care, which contributes to adverse health outcomes and misuse of resources. The mission of the IMPACT Collaboratory is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging.

August 2, 2022: IMPACT Collaboratory Announces New Funding Opportunities

Posted on by Damon Seils

Logo for the NIA IMPACT CollaboratoryThe NIA IMPACT Collaboratory announced requests for applications for 2 new funding opportunities: the Pilot Grant Program and the NIH Collaboratory Trials Program.  These programs support research and training to increase the nation’s capacity to conduct pragmatic clinical trials of nonpharmacological interventions within healthcare systems to improve care for people living with Alzheimer disease related dementias and their care partners.

The 1-year pilot grant awards will be eligible for funding of up to $175,000. The awards will support pilot projects that aim to generate preliminary data for the design and conduct of full-scale embedded pragmatic clinical trials of nonpharmacologic interventions in healthcare systems for persons living with Alzheimer disease and related dementias and their care partners.

The 2-year NIH Collaboratory Trial awards will be eligible for up to $500,000 for full-scale, Stage IV effectiveness ePCTs (based on the NIH Stage Model) that test, measure, and evaluate the effect of a care delivery intervention program in healthcare systems for people living with Alzheimer disease and related dementias and their care partners.

More than 5 million Americans are living with Alzheimer disease and related dementias. They are particularly vulnerable to receiving uncoordinated and poor-quality care, which contributes to adverse health outcomes and misuse of resources. The mission of the IMPACT Collaboratory is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging.

March 17, 2022: NIH Will Fund New NIH Collaboratory Trials That Address Health Disparities

Posted on by Damon Seils

Promotional banner for funding opportunity announcementThe NIH released a request for applications (RFA) for new NIH Pragmatic Trials Collaboratory Trial grants that address health disparities. NIH program and review staff will discuss the funding opportunity in an upcoming webinar. Registration for the webinar is required.

The RFA for this funding opportunity encourages applications that focus on improving health outcomes in populations that experience health disparities, such as higher rates of disease or mortality compared with the general population. Applications are due June 17, 2022. Letters of intent are due 30 days prior (May 17, 2022).

For the purposes of this funding opportunity, the NIH-designated U.S. health disparity populations definition includes: Blacks/African Americans, Hispanics/ Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities. 

Similar to the NIH Pragmatic Trials Collaboratory’s other NIH Collaboratory Trials, the new projects will have a planning and implementation phase and will be large-scale pragmatic or implementation trials that are embedded in healthcare delivery systems. The overarching goal of the projects is to improve care delivery and health outcomes across the lifespan.

Read our Living Textbook chapter about how to develop a compelling grant application for a pragmatic clinical trial.

October 25, 2021: NIH HEAL Initiative Issues RFA for Projects that Advance Health Equity in Pain Management

Posted on by terren.green@duke.edu

The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM recently announced a funding opportunity for new studies that aim to develop, test, and implement interventions that mitigate bias, discrimination, socioeconomic, or environmental barriers to quality pain assessment, treatment, and management for populations that experience health disparities (HDPs) in the United States.

For the purposes of this funding opportunity, the NIH-designated U.S. health disparity populations definition includes: Blacks/African Americans, Hispanics/ Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities.

The NIH HEAL Initiative supports research to improve treatment for opioid misuse and addiction and enhance pain management. This RFA calls for applications that “demonstrate an existing health disparity or health disparities in acute and/or chronic pain in the population of interest and outline a detailed plan for an evidence-based intervention to mitigate or eliminate the disparity(disparities) to improve pain and pain-related outcomes.”

Applications are due by 5pm on December 9, 2021.  Letters of intent are due 30 days prior (November 9, 2021).

This award will support a 1 to 2-year, milestone-driven planning phase (R61) with the possibility of an additional 4-year implementation phase (R33).

Read the full request for applications.

The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, is an aggressive, trans-NIH effort to speed scientific solutions to stem the national opioid public health crisis. Launched in April 2018, the initiative is focused on improving prevention and treatment strategies for opioid misuse and addiction, and enhancing pain management. For more information, visit: https://heal.nih.gov.

October 19, 2021: NIH Issues RFA for New NIH Collaboratory Trials That Address Health Disparities

Posted on by Karen Staman

NIH logoThe NIH recently released a request for applications (RFA) for new NIH Collaboratory Trial grants. The RFA encourages applications that focus on improving health outcomes in populations that experience health disparities, such as higher rates of disease or mortality compared with the general population. These populations may be defined by race, ethnicity, geography, or socioeconomic status.

Applications are due December 15, 2021. Letters of intent are due 30 days prior (November 15, 2021).

For the purposes of this funding opportunity, the NIH-designated U.S. health disparity populations definition includes: Blacks/African Americans, Hispanics/ Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities. 

Similar to the NIH Collaboratory’s other NIH Collaboratory Trials, the new projects will have a planning and implementation phase and will be large-scale pragmatic or implementation trials that are embedded in healthcare delivery systems. The overarching goal of the projects is to improve care delivery and health outcomes in Americans across the lifespan.

Read the full request for applications.

Read our Living Textbook chapter about how to develop a compelling grant application for a pragmatic clinical trial.