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NIH Collaboratory
Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures

Introduction

CHAPTER SECTIONS

ARCHIVED PAGE

Archived on November 26, 2025. Go to the latest version.

Dissemination Approaches For Different Stakeholders


Section 1

Introduction

Expand Contributors

Leah Tuzzio, MPH
David Chambers, DPhil

Ellen Tambor, MA
Jerry Suls, PhD
Beverly B. Green, MD, MPH
Susan Huang, MD, MPH
Kevin Weinfurt, PhD
Doug Zatzick, MD

Contributing Editors
Karen Staman, MS
Gina Uhlenbrauck, ELS
Liz Wing, MA

In academia, traditionally, researchers report their clinical study results in scientific journals. The results of pragmatic clinical research are often used to inform clinical and health care system decision makers, frame clinical guidelines, inform policy, and, ultimately, may be implemented into routine care or clinical operations. A paradigm shift has begun toward using different dissemination strategies to improve upon the fact that it takes 17 years for a small fraction (~14%) of original research to benefit patient care (Balas and Boren 2000), while the majority of research findings never influence care improvement.  The typical pathway to publication may not be an adequate means of dissemination of information to inform decision makers.

The mode and medium for disseminating the findings for a PCT should be tailored to the specific audience. The Patient-Centered Outcomes Research Institute (PCORI) recommends that patients and other stakeholders be involved in plans to disseminate study findings by, for example, identifying various audiences for dissemination, shaping the study design with final products in mind, and developing creative approaches to get information into the hands of those who need it.

Having stakeholders at the table from the start can be key to driving practice change if it is indicated from the results or to redesign/adjust if results are not as expected.  There are a wide range of stakeholder groups relevant to PCTs, and these are described in detail in the Engaging Stakeholders chapter. This chapter explores dissemination strategies for different stakeholders, beginning with considerations for transparent reporting to the scientific community and then moving to approaches for disseminating to patients and health systems leaders.

Next Section

SECTIONS

CHAPTER SECTIONS

sections

  1. Introduction
  2. Reporting to the Scientific Community: General Considerations
  3. Case Study: Journal Reviews of NIH Collaboratory Trials
  4. ClinicalTrials.gov
  5. Dissemination to Patients
  6. Dissemination to Healthcare System Leaders
  7. Additional Resources

Resources

Data and Resource Sharing Page

As part of the Collaboratory's commitment to sharing, all NIH Collaboratory Trials are expected to share data and resources, such as protocols, consent documents, public use datasets, computable phenotypes, and analytic code.

Learn more in these Living Textbook chapters:

Designing With Implementation and Dissemination in Mind

Dissemination and Implementation

Building Partnerships to Ensure a Successful Trial

REFERENCES

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Balas EA, Boren SA. 2000. Managing clinical knowledge for health care improvement. Yearb Med Inform. 65–70. PMID: 27699347.

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Version History

June 12, 2020: Added link to Data and Resources Sharing page to the Resources section (changes made by K. Staman).

February 11, 2020: Added link to Building Partnerships to Ensure a Successful Trial (changes made by K. Staman).

Published August 25, 2017

current section :

Introduction

  1. Introduction
  2. Reporting to the Scientific Community: General Considerations
  3. Case Study: Journal Reviews of NIH Collaboratory Trials
  4. ClinicalTrials.gov
  5. Dissemination to Patients
  6. Dissemination to Healthcare System Leaders
  7. Additional Resources

Citation:

Tuzzio L, Chambers D, Tambor E, et al. Dissemination Approaches For Different Stakeholders: Introduction. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Pragmatic Trials Collaboratory. Available at: https://rethinkingclinicaltrials.org/chapters/dissemination/dissemination-different-stakeholders/dissemination-to-different-stakeholder-introduction/. Updated December 3, 2025. DOI: 10.28929/083.

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