Alzheimer disease

September 13, 2022: IMPACT Collaboratory Extends Deadline for NIH Collaboratory Trial Letters of Intent

Posted on by Damon Seils

Logo for the NIA IMPACT CollaboratoryThe deadline to submit letters of intent for the NIA IMPACT NIH Collaboratory Trials Program has been extended to September 30, 2022.

This summer, the IMPACT Collaboratory announced a request for applications for its NIH Collaboratory Trials Program.  This funding mechanism supports large-scale pragmatic clinical trials embedded in healthcare systems to test the effectiveness of nonpharmacological interventions for people living with Alzheimer disease and related dementias and their care partners. The interventions will typically encompass relatively simple system changes or direct patient outreach, or successfully piloted programs ready for testing at scale. Awards are for $500,000 in direct costs for 18 months.

Prospective applicants should email their 1-page letter of intent describing their proposed NIH Collaboratory Trial to IMPACTcollaboratory@hsl.harvard.edu. This information will help determine whether the proposed project aligns with the goals of the request for applications prior to a full application. The goal of these NIH Collaboratory Trials is to generate evidence on effective care delivery practices that can be expanded and/or implemented in other systems.

An informational webinar about the program is available.

More than 5 million Americans are living with Alzheimer disease and related dementias. They are particularly vulnerable to receiving uncoordinated and poor-quality care, which contributes to adverse health outcomes and misuse of resources. The mission of the IMPACT Collaboratory is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging.

August 2, 2022: IMPACT Collaboratory Announces New Funding Opportunities

Posted on by Damon Seils

Logo for the NIA IMPACT CollaboratoryThe NIA IMPACT Collaboratory announced requests for applications for 2 new funding opportunities: the Pilot Grant Program and the NIH Collaboratory Trials Program.  These programs support research and training to increase the nation’s capacity to conduct pragmatic clinical trials of nonpharmacological interventions within healthcare systems to improve care for people living with Alzheimer disease related dementias and their care partners.

The 1-year pilot grant awards will be eligible for funding of up to $175,000. The awards will support pilot projects that aim to generate preliminary data for the design and conduct of full-scale embedded pragmatic clinical trials of nonpharmacologic interventions in healthcare systems for persons living with Alzheimer disease and related dementias and their care partners.

The 2-year NIH Collaboratory Trial awards will be eligible for up to $500,000 for full-scale, Stage IV effectiveness ePCTs (based on the NIH Stage Model) that test, measure, and evaluate the effect of a care delivery intervention program in healthcare systems for people living with Alzheimer disease and related dementias and their care partners.

More than 5 million Americans are living with Alzheimer disease and related dementias. They are particularly vulnerable to receiving uncoordinated and poor-quality care, which contributes to adverse health outcomes and misuse of resources. The mission of the IMPACT Collaboratory is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging.

February 3, 2022: IMPACT Collaboratory Seeks Letters of Intent for Pilot Grants Program

Posted on by Damon Seils

NIA IMPACT Collaboratory logoThe NIA IMPACT Collaboratory is seeking letters of intent from interested applicants for Cycle 4A of its Pilot Grants Program.

The 1-year pilot grant awards will fund up to $175,000 in direct costs for pilot studies that aim to generate preliminary data for full-scale embedded pragmatic clinical trials of nonpharmacologic interventions in healthcare systems for persons living with Alzheimer disease and related dementias and/or their care partners. In this grant cycle, the program will give priority to applications aim that improve care through behavioral economics “nudge” interventions; reduce inequities in healthcare; reduce potentially inappropriate medication use through de-prescribing; or improve care in emergency departments.

The required letters of intent are due by March 4. An optional informational webinar on February 14 will provide an overview of application details and an opportunity to ask questions. More information is available on the IMPACT Collaboratory website.

More than 5 million Americans are living with Alzheimer disease and related dementias. They are particularly vulnerable to receiving uncoordinated and poor-quality care, which contributes to adverse health outcomes and misuse of resources. The mission of the IMPACT Collaboratory is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging.

January 11, 2022: New Funding Opportunities Support Investigators at All Levels in Pragmatic Clinical Research

Posted on by Damon Seils

Logo for the NIA IMPACT CollaboratoryThe NIA IMPACT Collaboratory announced 2 new funding opportunities for researchers at all levels who are interested in pragmatic clinical trials embedded in healthcare systems (ePCTs). They include career development awards for early-stage researchers and a scholars program for midlevel and senior researchers.

  • Career Development Award: The IMPACT Collaboratory will fund 2-year career development awards to support the development of early-stage researchers who are seeking careers conducting ePCTs for people living with Alzheimer disease or related dementias and their care partners. Applications are due March 18. An optional informational webinar will be held on February 1.
  • Health Care System Scholars Program – The IMPACT Collaboratory’s Health Care System Scholars Program offers midlevel and senior investigators an opportunity to develop ePCTs with healthcare systems interested in improving the care provided to people living with Alzheimer disease or related dementias and their care partners. Letters of intent are due February 8. An optional informational webinar will be held on January 20.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging. Its mission is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

October 11, 2021: IMPACT Collaboratory Issues RFA for New NIH Collaboratory Trials

Posted on by Damon Seils

Logo for the NIA IMPACT CollaboratoryThe IMPACT Collaboratory last week published a request for applications for the second cycle of its NIH Collaboratory Trials Program.

IMPACT will fund up to 2 full-scale embedded pragmatic clinical trials that test, measure, and evaluate the effects of a nonpharmacological care delivery intervention program in a healthcare system for people living with Alzheimer disease and related dementias and their care partners. The goal of the NIH Collaboratory Trials Program is to generate evidence on effective care delivery practices that can be expanded and/or implemented in other systems.

Read the full request for applications.

The IMPACT Collaboratory is supported by a grant from the National Institute on Aging.

September 21, 2020: IMPACT Collaboratory Opens Application for 2022 Training Workshop

Posted on by Damon Seils

Logo for the NIA IMPACT CollaboratoryThe IMPACT Collaboratory is inviting applications from early- and mid-career researchers for its second annual training workshop, “Building Skills to Conduct Embedded Pragmatic Clinical Trials (ePCTs) Among People Living With Dementia (PLWD) and Their Care Partners.” A limited number of participants will be accepted to attend the event on January 26 and 27, 2022.

This virtual 1.5-day workshop will provide a foundation in practical aspects of designing and conducting ePCTs in Alzheimer disease and related dementias through a combination of panel discussions, small group sessions, and networking opportunities with experts in the field. Workshop modules will focus on integrating health equity into ePCTs, ethical considerations for ePCTs for PLWD and their care partners, and the challenges and opportunities related to conducting ePCTs with care partners of people living with dementia.

Read more about the event and how to apply.

The IMPACT Collaboratory is supported by a grant from the National Institute on Aging. Its mission is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

August 31, 2021: $56 Million NIH Grant Will Expand Alzheimer Disease Research

Posted on by Damon Seils
Headshot of Dr. Eric Larson
Dr. Eric Larson

The National Institute on Aging is awarding a grant expected to total $55.6 million to the Adult Changes in Thought (ACT) study, led by Kaiser Permanente Washington, the University of Washington School of Medicine, and the University of California, San Diego. The funds will be used to advance the understanding of Alzheimer disease and to diversify and broaden participation in the study.

Read the full press release.

ACT is led by co–principal investigator Dr. Eric Larson, who is also a principal investigator of the NIH Collaboratory Coordinating Center. He leads the NIH Collaboratory’s Health Care Systems Interactions Core.

Larson founded the ACT study in Seattle in 1994.

“We have become a dynamic ‘living laboratory’ of aging,” said Larson. “Thanks to the generosity of the ACT volunteers, we can investigate years of detailed medical records for study participants—often dating back decades before the study began because of their Kaiser Permanente membership in Washington—and do state-of-the-art studies of the brains from those who consent to autopsy,” he said.

The ACT team also includes faculty and staff from Boston University, Columbia University, Swedish Medical Center in Seattle, the University of California Riverside, the University of Pennsylvania, the University of Toronto, and the University of Wisconsin-Madison.

August 30, 2021: IMPACT Collaboratory Seeks Letters of Intent for Pilot Grants Program

Posted on by Damon Seils

NIA IMPACT Collaboratory logoThe NIA IMPACT Collaboratory is seeking letters of intent from interested applicants for Cycle 3B of its Pilot Grants Program.

More information is available on the IMPACT Collaboratory website.

The 1-year pilot grant awards will likely be eligible for funding of up to $175,000 in direct costs. The awards will support pilot projects that aim to generate preliminary data for the design and conduct of full-scale embedded pragmatic clinical trials of nonpharmacologic interventions in healthcare systems for persons living with Alzheimer disease and related dementias and/or their care partners. The IMPACT Collaboratory will give preference to applications that address care for traditionally marginalized or underrepresented populations in clinical research and those that promote health equity.

More than 5 million Americans are living with Alzheimer disease and related dementias. They are particularly vulnerable to receiving uncoordinated and poor-quality care, which contributes to adverse health outcomes and misuse of resources. The mission of the IMPACT Collaboratory is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging.

July 15, 2021: Richard Platt to Lead New IMPACT Collaboratory NIH Collaboratory Trial

Posted on by Damon Seils
Dr. Xioajuan Li and Dr. Richard Platt
Dr. Xioajuan Li and Dr. Richard Platt

Longtime NIH Collaboratory investigator Dr. Richard Platt will serve as co–principal investigator of a new embedded pragmatic clinical trial with Dr. Xiaojuan Li as part of the IMPACT Collaboratory. The IMPACT Collaboratory announced Li and Platt as awardees of its NIH Collaboratory Trials Program for their project Co-CARE-AD, the Collaborative Care Coordination Program for Alzheimer’s Disease and Related Dementias.

The IMPACT Collaboratory’s NIH Collaboratory Trials Program is a new funding mechanism to support full-scale, embedded pragmatic clinical trials testing nonpharmacologic interventions for people living with Alzheimer disease and related dementias and their care partners that are linked to the needs of a health care system.

Co-CARE-AD will evaluate the effectiveness of the Dementia Care Consultation program to provide multicomponent care coordination and support for community-dwelling Medicare Advantage plan members. Read more about Co-CARE-AD.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging.

June 17, 2021: Letters of Intent for IMPACT Collaboratory Pilot Grants Due September 17

Posted on by Damon Seils

NIA IMPACT Collaboratory logoThe NIA IMPACT Collaboratory will publish a request for applications for pilot grants on August 16, 2021, with letters of intent due September 17, 2021.

More information is available on the IMPACT Collaboratory website.

The 1-year pilot grant awards will likely be eligible for funding of up to $175,000 in direct costs. The awards will support pilot projects that aim to generate preliminary data for the design and conduct of full-scale embedded pragmatic clinical trials of nonpharmacologic interventions in healthcare systems for persons living with Alzheimer disease and related dementias and/or their care partners. The IMPACT Collaboratory will give preference to applications that address care for traditionally marginalized or underrepresented populations in clinical research and those that promote health equity.

More than 5 million Americans are living with Alzheimer disease and related dementias. They are particularly vulnerable to receiving uncoordinated and poor-quality care, which contributes to adverse health outcomes and misuse of resources. The mission of the IMPACT Collaboratory is to advance care for persons with dementia and their caregivers in real-world settings by building national capacity to conduct pragmatic clinical trials that test interventions embedded in healthcare systems.

The NIA IMPACT Collaboratory is supported by a grant from the National Institute on Aging.