August 31, 2021: $56 Million NIH Grant Will Expand Alzheimer Disease Research

Headshot of Dr. Eric Larson
Dr. Eric Larson

The National Institute on Aging is awarding a grant expected to total $55.6 million to the Adult Changes in Thought (ACT) study, led by Kaiser Permanente Washington, the University of Washington School of Medicine, and the University of California, San Diego. The funds will be used to advance the understanding of Alzheimer disease and to diversify and broaden participation in the study.

Read the full press release.

ACT is led by co–principal investigator Dr. Eric Larson, who is also a principal investigator of the NIH Collaboratory Coordinating Center. He leads the NIH Collaboratory’s Health Care Systems Interactions Core.

Larson founded the ACT study in Seattle in 1994.

“We have become a dynamic ‘living laboratory’ of aging,” said Larson. “Thanks to the generosity of the ACT volunteers, we can investigate years of detailed medical records for study participants—often dating back decades before the study began because of their Kaiser Permanente membership in Washington—and do state-of-the-art studies of the brains from those who consent to autopsy,” he said.

The ACT team also includes faculty and staff from Boston University, Columbia University, Swedish Medical Center in Seattle, the University of California Riverside, the University of Pennsylvania, the University of Toronto, and the University of Wisconsin-Madison.

August 9, 2021: ‘Pause’ for COVID-19 Complicates Research Embedded in Healthcare Systems

Leaders of the NIH Collaboratory’s Health Care Systems Interactions Core Working Group spoke in a recent interview about the impacts of the COVID-19 pandemic on the NIH Collaboratory Trials.

“Some of the projects are facing healthcare systems that are on pause for research,” said Leah Tuzzio, a senior research associate at Kaiser Permanente Washington Health Research Institute (KPWHRI) and a member of the Core. “It’s happened before when policy changes or when [electronic health record] systems change or when someone important leaves, but the pandemic has had a huge impact,” she said.

“Healthcare systems are strongly influenced by the environment and by changes in their environment, and so any pragmatic trial that’s really embedded in the healthcare system will be affected by the environment around it,” said Dr. Eric Larson, a KPWHRI senior investigator and the chair of the Core. Healthcare systems participating in the NIH Collaboratory NIH Collaboratory Trials have been overwhelmed by their number one priority, which—in addition to caring for their patients—is adapting to COVID, Larson said.

In addition to guiding the NIH Collaboratory Trials through pandemic-related challenges, the Health Care Systems Interactions Core has been working on several long-term projects.

“One of the things that we’re currently working on is a typology of the healthcare systems that have participated in [the GRACE and BeatPain Utah NIH Collaboratory Trials] as well as the projects that came before,” said Core project manager Rachel Hays. The Core is surveying NIH Collaboratory Trial investigators about what lessons they would pass on to future pragmatic trial investigators about building partnerships with their participating healthcare systems, she said.

 

Screen shot of interview with Eric Larson, Leah Tuzzio, and Rachel Hays
Dr. Eric Larson, Leah Tuzzio, and Rachel Hays