Workshop

March 10, 2026: NIH Pragmatic Trials Collaboratory to Host Workshop at Society for Clinical Trials 47th Annual Meeting

Posted on by Damon Seils

Registration open, Innovations in Embedded Pragmatic Clinical Trials, a workshop at the Society for Clinical Trials 47th Annual MeetingThe NIH Pragmatic Trials Collaboratory will offer a preconference workshop at the Society for Clinical Trials 47th Annual Meeting in Phoenix. Registration for the workshop is now open.

The half-day workshop, “Innovations in Embedded Pragmatic Clinical Trials,” will introduce concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems.

The workshop will provide an introduction to opportunities for embedded healthcare systems research, along with strategies for conducting patient-centered clinical trials that provide real-world evidence necessary to inform improvements in healthcare delivery. The workshop format is as follows:

  • A series of didactic presentations, each with ample time for attendee Q & A with presenters. Firsthand experiences with embedded pragmatic clinical trials and case studies from the NIH Collaboratory Trials will support and illustrate the topics presented.
  • A small group learning activity in which attendees work together to problem-solve real challenges encountered in embedded pragmatic clinical trials.
  • An interactive, facilitated panel discussion with experienced principal investigators from the NIH Collaboratory Trials.

Goals of the workshop:

  1. Describe the characteristics and utility of embedded pragmatic clinical trials
  2. Introduce attendees to the unique opportunities and challenges of designing, conducting, and implementing pragmatic trials within healthcare systems
  3. Explain how the latest information capabilities can be employed in embedded pragmatic trials to address important public health questions

The theme of this year’s SCT Annual Meeting is “Advancing Public Health: Clinical Trials in an Era of Cutting-Edge Information Capabilities.” The conference brings together the clinical trials community from academia, the pharmaceutical and device industries, government agencies, medical groups and centers, and clinical research entities.

WORKSHOP DETAILS AND REGISTRATION
Sunday, May 17, 1:00-5:00 pm
Arizona Grand Resort & Spa, Phoenix, Arizona

March 2, 2026: Registration Opens for Pragmatic Trials Workshop at SCT 47th Annual Meeting

Posted on by Damon Seils

Registration open, Innovations in Embedded Pragmatic Clinical Trials, a workshop at the Society for Clinical Trials 47th Annual MeetingThe NIH Pragmatic Trials Collaboratory will offer a preconference workshop at the Society for Clinical Trials 47th Annual Meeting in Phoenix. Registration for the workshop is now open.

The half-day workshop, “Innovations in Embedded Pragmatic Clinical Trials,” will introduce concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems.

The workshop will provide an introduction to opportunities for embedded healthcare systems research, along with strategies for conducting patient-centered clinical trials that provide real-world evidence necessary to inform improvements in healthcare delivery. The workshop format is as follows:

  • A series of didactic presentations, each with ample time for attendee Q & A with presenters. Firsthand experiences with embedded pragmatic clinical trials and case studies from the NIH Collaboratory Trials will support and illustrate the topics presented.
  • A small group learning activity in which attendees work together to problem-solve real challenges encountered in embedded pragmatic clinical trials.
  • An interactive, facilitated panel discussion with experienced principal investigators from the NIH Collaboratory Trials.

Goals of the workshop:

  1. Describe the characteristics and utility of embedded pragmatic clinical trials
  2. Introduce attendees to the unique opportunities and challenges of designing, conducting, and implementing pragmatic trials within healthcare systems
  3. Explain how the latest information capabilities can be employed in embedded pragmatic trials to address important public health questions

The theme of this year’s SCT Annual Meeting is “Advancing Public Health: Clinical Trials in an Era of Cutting-Edge Information Capabilities.” The conference brings together the clinical trials community from academia, the pharmaceutical and device industries, government agencies, medical groups and centers, and clinical research entities.

WORKSHOP DETAILS AND REGISTRATION
Sunday, May 17, 1:00-5:00 pm
Arizona Grand Resort & Spa, Phoenix, Arizona

January 27, 2026: Workshop Materials Available From ‘Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effective Interventions’

Posted on by Damon Seils

Logo for the 18th Annual Conference on the Science of Dissemination and Implementation in HealthComplete materials are now available from the NIH Pragmatic Trials Collaboratory’s recent workshop, “Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effective Interventions.”

The full-day workshop, held on December 14 at AcademyHealth’s 18th Annual Conference on the Science of Dissemination and Implementation in Health, introduced concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems, with a focus on methods relevant to health services researchers. Presenters shared firsthand experiences and case studies from the NIH Collaboratory Trials. The learning objectives of the workshop included:

  • To identify areas of synergy between embedded pragmatic clinical trials and implementation research
  • To introduce participants to the unique characteristics and challenges of designing, conducting, and implementing pragmatic clinical trials embedded in diverse healthcare systems, and describe opportunities for integrating implementation research methods into these trials
  • To increase the capacity of health services researchers to address important clinical questions with embedded pragmatic clinical trials, and share lessons from implementation science for supporting intervention adoption, sustainment, scale-up, and/or deimplementation

Access the complete workshop materials, including slides, speaker biographies, and the full participant guide.

November 25, 2025: Materials Now Available From NIH-Hosted Workshop, ‘Digging Into Dilemmas of Pragmatic Clinical Trials’

Posted on by Damon Seils

Materials and videocast recordings are now available from the NIH Pragmatic Trials Collaboratory’s recent workshop, “Digging Into Dilemmas of Pragmatic Clinical Trials.“

The 2-day workshop, hosted by the NIH, featured a keynote address by David Zaas, president of Atrium Health Wake Forest Baptist, gaps and opportunities for researchers in the US healthcare system.

The first day of the workshop focused on the landscape for pragmatic research, including stressors on the healthcare system and barriers and opportunities for real-world research, and platform trials as an emerging method. The second day explored today’s challenges and emerging opportunities in pragmatic trials, including what can be learned from pragmatic trials with null findings, and the role of pragmatic trials in a time of increasing use of artificial intelligence.

Access the complete workshop materials, including slides and videocast recordings.

  • Keynote: Landscape of Healthcare in America: Gaps and Opportunities (That Researchers Need to Hear)
    • David W. Zaas, MD, MBA
  • Session 1: Understanding the Needs and Priorities of Healthcare Systems Across Communities
    • Cherise B. Harrington, PhD, MPH (moderator); Rachel Gold, PhD, MPH; Caleb C. Holtzer, MD, MPH; Sebastian T. Tong, MD, MPH
  • Session 2: Realizing the Potential of Platform Trials
    • Adrian F. Hernandez, MD, MHS (moderator); Marianne Kearney Chase; Martin Landray, MB ChB, PhD; Gregory Levin, PhD; Christopher Lindsell, PhD; Bijoy Menon, MBBS, MD, DM, MSc
  • Session 3: What Do We Learn From Null Pragmatic Trials?
    • Kevin P. Weinfurt, PhD (moderator); Corita R. Grudzen, MD, MSHS; Michael Ho, MD, PhD; Vincent Mor, PhD; Miguel A. Vazquez, MD
  • Session 4: What Is the Role of ePCTs in the Age of Artificial Intelligence?
    • Emily C. O’Brien, PhD (moderator); Adrian F. Hernandez, MD, MHS; Michael Ho, MD, PhD; Rohan Khera, MD, MS; Edward R. Melnick, MD, MHS; Jeremy Sugarman, MD, MPH, MA

Digging Into Dilemmas of Pragmatic Clinical Trials: NIH-Hosted Workshop (November 2025)

Posted on by Sophia Ramirez

November 4-5, 2025: This 2-day workshop focused on the perspectives of providers, healthcare systems, regulators, and payers that can inform better approaches to research embedded in healthcare delivery. A series of panels discussed considerations for research in healthcare systems across a variety of communities; platform trials as an emerging method; implications of pragmatic trials with null findings for future pragmatic research; and the role of pragmatic trials in comparative effectiveness research of artificial intelligence algorithms.

Agenda

Workshop Description

Workshop Recording

Agenda, Slides, and Recordings

Day 1: November 4

Welcome and Introduction

Wendy Weber, ND, PhD, MPH*
Helene Langevin, MD*
Presented by: Lesley Curtis, PhD

Keynote: Landscape of Healthcare in America: Gaps and Opportunities (That Researchers Need to Hear)

David Zaas, MD, MBA

Session 1: Understanding Needs and Priorities of Health Systems Across Communities

Moderator: Cherise Harrington, PhD, MPH

Panel:

  • Aimee Eden, PhD, MPH*
  • Rachel Gold, PhD, MPH
  • Caleb Holtzer, MD, MPH
  • Ann Sheehy, MD, MS*
  • Sebastian Tong, MD, MPH

Session 2: Realizing the Potential of Platform Trials

Moderator: Adrian Hernandez, MD, MHS

Panel:

  • Marianne Kearney Chase
  • Martin Landray, MB ChB, PhD
  • Gregory Levin, PhD
  • Christopher Lindsell, PhD
  • Bijoy Menon, MBBS, MD, DM, MSc

Summary and Concluding Remarks

Lesley Curtis, PhD
Cherise Harrington, PhD, MPH
Adrian Hernandez, MD, MHS
Wendy Weber, ND, PhD, MPH*

Day 2: November 5

Welcome and Introduction

Wendy Weber, ND, PhD, MPH*
Helene Langevin, MD*
Presented by: Kevin Weinfurt, PhD

Session 3: What Do We Learn From Null Pragmatic Trials?

Presenter: Kevin Weinfurt, PhD

Moderator: Josephine Briggs, MD

Panel:

  • Corita Grudzen, MD, MSHS
  • Michael Ho, MD, PhD
  • Vincent Mor, PhD
  • Miguel Vazquez, MD

Session 4: What Is the Role of ePCTs in the Age of Artificial Intelligence?

Moderator: Emily O'Brien, PhD

Panel:

  • Adrian Hernandez, MD, MHS
  • Michael Ho, MD, PhD
  • Rohan Khera, MD, MS
  • Edward Melnick, MD, MHS
  • Jeremy Sugarman, MD, MPH, MA
  • Kenneth Wiley, PhD*


Summary and Concluding Remarks

Josephine Briggs, MD
Lesley Curtis, PhD
Emily O'Brien, PhD
Wendy Weber, ND, PhD, MPH*
Kevin Weinfurt, PhD

*Participated in workshop planning but unable to attend the live event due to the federal government shutdown.

November 4, 2025: NIH Collaboratory to Host Workshop at AcademyHealth Dissemination and Implementation Conference

Posted on by Damon Seils

Logo for the 18th Annual Conference on the Science of Dissemination and Implementation in HealthThe NIH Pragmatic Trials Collaboratory will offer a full-day workshop at the 18th Annual Conference on the Science of Dissemination and Implementation in Health in National Harbor, Maryland. The workshop, “Dissemination & Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effective Interventions,” will introduce concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems, with a particular focus on methods relevant to health services researchers.

The learning objectives of the workshop include:

  • To identify key areas of synergy between pragmatic trials and implementation research
  • To introduce attendees to the unique characteristics and challenges of designing, conducting, and implementing pragmatic clinical trials embedded within diverse health care systems, and to describe opportunities for integrating implementation research methods into pragmatic trials
  • To increase the capacity of health services researchers to address important clinical questions with embedded pragmatic clinical trials and share lessons from implementation science for supporting intervention adoption, sustainment, scale-up, and/or deimplementation

The theme of this year’s D&I conference is “Realizing the Benefits of Dissemination & Implementation Science.” The annual conference is cohosted by the NIH and AcademyHealth.

WORKSHOP DETAILS AND REGISTRATION
Sunday, December 14, 10:00 am-6:00 pm
Gaylord National, National Harbor, Maryland
Information and registration: https://academyhealth.org/page/2025-di-adjunct-events

October 22, 2024: Registration Opens for Pragmatic Trials Workshop at AcademyHealth–NIH Dissemination & Implementation Conference

Posted on by Damon Seils

AcademyHealth D&I Conference logoThe NIH Pragmatic Trials Collaboratory will offer a full-day workshop at the 17th Annual Conference on the Science of Dissemination and Implementation in Health in Arlington, Virginia. The workshop, “Dissemination & Implementation in Embedded Pragmatic Trials: Getting the Timing Right in Real-World Research,” will introduce concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems, with a particular focus on methods relevant to health services researchers.

The learning objectives of the workshop include:

  • To identify key areas of synergy between pragmatic trials and implementation research
  • To introduce attendees to the unique characteristics and challenges of designing, conducting, and implementing pragmatic clinical trials embedded within diverse health care systems, and to describe opportunities for integrating implementation research methods into pragmatic trials
  • To increase the capacity of health services researchers to address important clinical questions with embedded pragmatic clinical trials and share lessons from implementation science for supporting intervention adoption, sustainment, scale-up, and/or deimplementation

The theme of this year’s D&I conference is “Moving Fast and Slow: Optimizing the Pace of Implementation.” The annual conference is cohosted by the NIH and AcademyHealth.

WORKSHOP DETAILS AND REGISTRATION
Sunday, December 8, 10:00 am-6:00 pm
Crystal Gateway Marriott, Arlington, Virginia

Going From Zero to 100: Generating Evidence Through Pragmatic Research to Address Pressing Healthcare Issues: NIH-Hosted Workshop (July 2024)

Posted on by dcridigital

July 15-16, 2024: This 2-day workshop focused on the preparatory actions researchers can undertake in the planning and application phase (Phase Zero) to ensure pragmatic clinical trials yield actionable evidence for a variety of settings. Key aspects include formulating the right research question and engaging with patients, funders, and healthcare system leaders. The workshop also addressed challenges in initiating trials across diverse settings, such as navigating data systems, site diversification, and reducing administrative burdens.

Agenda

Workshop Description

Workshop Summary

Videocast Recording: Day 1

Videocast Recording: Day 2

Agenda and Slides

Day 1: July 15

Welcome and Introduction

Wendy Weber, ND, PhD, MPH
Helene Langevin, MD

Session 1: Phase Zero: Getting the Research Question Right

Moderator: Kevin Weinfurt, PhD

Panel:

Session 2: Engagement as the Cornerstone in Pragmatic Research

Moderator: Gregory Simon, MD

Panel:

Summary and Concluding Remarks

Lesley Curtis, PhD
Gregory Simon, MD
Wendy Weber, ND, PhD, MPH
Kevin Weinfurt, PhD

Day 2: July 16

Welcome and Introduction

Wendy Weber, ND, PhD, MPH
Helene Langevin, MD

Keynote: Connecting Lab, Clinic and Community: Communities Advancing Research Equity (CARE) for Health™

Monica Bertagnolli, MD

Session 3: How to Use Data From Disparate Data Systems

Moderator: Keith Marsolo, PhD

Panel:

Session 4: Retrofitting, Reimagining, and Redesigning Health Care Systems to Reach Populations Most Affected by Health Inequities

Moderator: Rosa Gonzalez-Guarda, PhD, MPH, RN

Panel:

Session 5: Overcoming Administrative Burden in Pragmatic Research

Moderator: Adrian Hernandez, MD, MHS

Panel:

Summary and Concluding Remarks

Lesley Curtis, PhD
Rosa Gonzalez-Guarda, PhD, MPH, RN
Adrian Hernandez, MD, MHS
Keith Marsolo, PhD
Wendy Weber, ND, PhD, MPH

March 5, 2024: Registration Opens for Pragmatic Trials Workshop at SCT 45th Annual Meeting

Posted on by Damon Seils

The NIH Pragmatic Trials Collaboratory will offer a preconference workshop at the 45th Annual Meeting of the Society for Clinical Trials in Boston. Registration for the workshop is now open.

The workshop, “Patient-Centered Research in Real-World Settings: Essentials of Embedded Pragmatic Clinical Trials,” will introduce concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems, with a particular focus on engaging stakeholders and measuring outcomes, including patient-reported outcomes.

The workshop will provide an introduction to the opportunities for embedded healthcare systems research, along with strategies for conducting patient-centered clinical trials that provide real-world evidence necessary to inform improvements in healthcare. The workshop format is as follows:

  • A series of didactic presentations, each with ample time for attendee Q & A with presenters. Firsthand experiences with embedded pragmatic clinical trials and case studies from the NIH Pragmatic Trials Collaboratory will support and illustrate the topics presented. Live polling will be used to encourage attendee interaction around the topics.
  • Small group hands-on learning activity in which attendees work together to problem-solve real challenges encountered in embedded pragmatic clinical trials. A report out from the activity will further support collaborative learning.
  • Interactive, facilitated panel discussion with experienced principal investigators from the NIH Collaboratory Trials.

Goals of the workshop:

  1. To clarify the definition of pragmatic clinical trials embedded in healthcare systems and explain their utility.
  2. To introduce attendees to the unique characteristics and challenges of designing, conducting, and implementing pragmatic clinical trials embedded within diverse health care systems.
  3. To increase the capacity to address important patient-centered questions with ePCTs in real-world settings.

The theme of this year’s SCT Annual Meeting is “It Takes a Village: Patient Centered Partnerships in Clinical Trials.” The conference brings together the clinical trials community from academia, the pharmaceutical and device industries, government agencies, medical groups and centers and clinical research entities.

WORKSHOP DETAILS AND REGISTRATION
Sunday, May 19, 8:00 am-12:00 pm
Boston Marriott Copley Place, Boston, Massachusetts

October 9, 2023: Registration Opens for Pragmatic Trials Workshop at AcademyHealth Dissemination & Implementation Conference

Posted on by Damon Seils

The NIH Pragmatic Trials Collaboratory will offer a full-day workshop at the 16th Annual Conference on the Science of Dissemination and Implementation in Health in Arlington, Virginia. The workshop, “Dissemination & Implementation in Embedded Pragmatic Trials: Raising the Bar for Real-World Research,” will introduce concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems, with a particular focus on methods relevant to health services researchers.

The learning objectives of the workshop include:

  • To identify key areas of synergy between pragmatic trials and implementation research
  • To introduce attendees to the unique characteristics and challenges of designing, conducting, and implementing pragmatic clinical trials embedded within diverse health care systems, and to describe opportunities for integrating implementation research methods into pragmatic trials
  • To increase the capacity of health services researchers to address important clinical questions with embedded pragmatic clinical trials and share lessons from implementation science for supporting intervention adoption, sustainment, scale-up, and/or deimplementation

The theme of this year’s D&I conference is “Raising Expectations for D&I Science: Challenges and Opportunities.” The annual conference is cohosted by the NIH and AcademyHealth.

WORKSHOP DETAILS AND REGISTRATION
Sunday, December 10, 10:00 am-6:00 pm
Gateway Marriott, Arlington, Virginia