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NIH Pragmatic Trials Collaboratory 2022 Annual Workshop Critical Questions for Pragmatic Clinical Trialists: Insights From the NIH Pragmatic Trials Collaboratory’s First Decade

The NIH Pragmatic Trials Collaboratory will hold a virtual workshop June 15-16, 2022, to explore questions critical to designing and implementing pragmatic clinical trials conducted within healthcare systems. This workshop is an opportunity to glean the most salient lessons learned from an experienced group of the pragmatic trial investigators who will openly share the challenges they have encountered, solutions they have developed, and thoughts for the future.

The workshop will include 4 moderated webinar discussions with panels of experts that will focus on changes and current best practices regarding the use of electronic health records for pragmatic research, considerations for pragmatic trial study design, how to optimize a 1-year planning phase for a pragmatic trial, and tips for implementing interventions in complex health systems.

All sessions are free and open to the public.

Register today.

See the full schedule.

February 24, 2022: NIH Pragmatic Trials Collaboratory to Offer Workshop on Essentials of ePCTs at 2022 HCSRN Conference

Posted on by Damon Seils

HCSRN 2022 logoThe NIH Pragmatic Trials Collaboratory is partnering with the Health Care Systems Research Network (HCSRN) to offer a workshop at the 2022 HCSRN Conference to be held in April in Pasadena, California.

The workshop, Essentials of Embedded Pragmatic Clinical Trials, will introduce concepts in the design, conduct, and implementation of embedded pragmatic clinical trials (ePCTs). ePCTs are randomized trials conducted within healthcare systems and use streamlined procedures and existing infrastructure to answer important medical questions for patients, providers, and healthcare system leaders.

Offered free to all conference registrants, the workshop will include firsthand ePCT experiences and case studies from the NIH Pragmatic Trials Collaboratory. Speakers will include senior investigators from the NIH Pragmatic Trials Collaboratory’s Trials and Coordinating Center.

Register for the conference today and add the workshop at no extra charge!

CONFERENCE DETAILS AND REGISTRATION
HCSRN 2022: Promoting Collaboration and Partnerships to Advance Health Equity
April 12-14, 2022

June 23, 2021: NIH to Host Webinar on Access to Controlled Data

Posted on by Damon Seils

NIH logoThe NIH will host a webinar titled “Streamlining Access to Controlled Data at NIH: Tackling Challenges and Identifying Opportunities” on July 9 from 10:00 am to 1:00 pm ET. Registration for the event is open to all interested participants.

This webinar will explore perspectives on the challenges and opportunities in accessing controlled data stewarded by the NIH. The event will include opportunities to hear from experts on the topic and to ask questions and provide ideas with follow-up activities. The webinar will be of particular interest to data scientists and investigators who use NIH data resources.

Organized by the NIH Controlled Data Access Coordination Working Group, the webinar will help inform the group’s recommendations to NIH leadership on ways to streamline access to controlled data.

Read the webinar agenda and register today.

June 3, 2021: Town Hall Will Introduce ACTIV-6 Study to Potential Sites and Investigators

Posted on by Damon Seils

Leaders of the ACTIV-6 study, featured recently during NIH Collaboratory Grand Rounds, will hold a town hall Wednesday, June 9, to share information about the study with interested stakeholders, including sites and investigators that may want to participate. The leadership team will describe the rationale for ACTIV-6, share an overview of the platform and objectives, and provide information about how to join and contribute to the study.

Contact DCRI-ACTIV6@dm.duke.edu if you would to receive a calendar invitation the event. The town hall will be recorded for those who are unable to attend.

ACTIV-6, part of the NIH’s Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) program, is a platform trial that will test whether several already approved medications can be repurposed for treating symptoms of mild to moderate COVID-19 in nonhospitalized patients.

View the April 30 Grand Rounds webinar.

April 26, 2021: Registration for 2021 HCSRN Conference to Close on May 3rd

Posted on by Damon Seils

Logo for HCSRN 2021Registration for the 2021 Health Care Systems Research Network (HCSRN) Conference will close on Monday, May 3. The NIH Collaboratory is partnering with HCSRN to offer a workshop at the conference, which will be held virtually on May 11 and 12.

The workshop, Essentials of Embedded Pragmatic Clinical Trials (ePCTs), will provide an introduction to investigative opportunities for pragmatic clinical trials embedded in healthcare systems, along with strategies for conducting clinical trials that provide real-world evidence necessary to inform both practice and policy.

Offered free to all conference registrants, the workshop will include firsthand ePCT experiences and case studies from the NIH Collaboratory. Speakers will include program officers and senior staff from NIH Institutes, Centers, and Offices and senior investigators from the NIH Collaboratory Demonstration Projects and the Coordinating Center.

The learning objectives of the workshop include:

  • To clarify the definition of ePCTs and explain their utility
  • To introduce attendees to the unique characteristics and challenges of designing, conducting, and implementing ePCTs within diverse health care systems
  • To increase the capacity of health services researchers to address important clinical questions with ePCTs

CONFERENCE DETAILS AND REGISTRATION
HCSRN 2021: Looking Forward and Embracing Change—Preparedness for the Future During Uncertain Times
May 11-12, 2021

February 4, 2021: NIH Collaboratory to Offer Workshop on Essentials of ePCTs at 2021 HCSRN Conference

Posted on by Damon Seils

Logo for HCSRN 2021The NIH Collaboratory is partnering with the Health Care Systems Research Network (HCSRN) to offer a workshop at the 2021 HCSRN Conference, which will be held virtually on May 11 and 12.

The workshop, Essentials of Embedded Pragmatic Clinical Trials (ePCTs), will provide an introduction to investigative opportunities for pragmatic clinical trials embedded in healthcare systems, along with strategies for conducting clinical trials that provide real-world evidence necessary to inform both practice and policy.

Offered free to all conference registrants, the workshop will include firsthand ePCT experiences and case studies from the NIH Collaboratory. Speakers will include program officers and senior staff from NIH Institutes, Centers, and Offices and senior investigators from the NIH Collaboratory Trials and the Coordinating Center.

The learning objectives of the workshop include:

  • To clarify the definition of ePCTs and explain their utility
  • To introduce attendees to the unique characteristics and challenges of designing, conducting, and implementing ePCTs within diverse health care systems
  • To increase the capacity of health services researchers to address important clinical questions with ePCTs

CONFERENCE DETAILS AND REGISTRATION
HCSRN 2021: Looking Forward and Embracing Change—Preparedness for the Future During Uncertain Times
May 11-12, 2021

June 22, 2020: NIH Offers Methods Webinar on Stepped-Wedge Cluster Randomized Trials

Posted on by Damon Seils

The NIH Office of Disease Prevention will continue its Methods: Mind the Gap webinar series on July 14 with “Overview of Statistical Models for the Design and Analysis of Stepped Wedge Cluster Randomized Trials.” Dr. Fan Li of Yale University, a longtime participant in the NIH Collaboratory’s Biostatistics and Study Design Core Working Group, will lead the webinar.

The Methods: Mind the Gap series explores research design, measurement, intervention, data analysis, and other methods of interest in prevention science. The July 14 session will address the stepped-wedge cluster randomized design, which has received increasing attention in pragmatic clinical trials (PCTs) and implementation science research. Since the design’s introduction, a variety of mixed-effects model extensions have been proposed for the design and analysis of PCTs. Dr. Li will provide a general model representation and discuss model extensions as alternative ways to characterize secular trends, intervention effects, and sources of heterogeneity. He will also review key model ingredients and clarify their implications for the design and analysis of stepped-wedge cluster randomized trials.

Register in advance to join the online presentation. Registration is required.