July 29, 2025: AI-Triggered Notifications of Cancer Progression in Clinical Trials, in This Week’s Rethinking Clinical Trials Grand Rounds

Headshot of Dr. Kenneth Kehl
Dr. Kenneth Kehl

In this Friday’s Rethinking Clinical Trials Grand Rounds, Kenneth Kehl of the Dana-Farber Cancer Institute will present “Clinical Trial Notifications Triggered by Artificial Intelligence–Detected Cancer Progression.”

The Grand Rounds session will be held on Friday, August 1, 2025, at 1:00 pm eastern.

Kehl is a physician and associate director of research at the Dana-Farber Cancer Institute and an assistant professor of medicine at Harvard Medical School.

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July 23, 2025: Initial Outcomes of the NOHARM Trial, in This Week’s Rethinking Clinical Trials Grand Rounds

Headshots of Dr. Andrea Cheville and Dr. Jon Tilburt
Dr. Andrea Cheville and Dr. Jon Tilburt

In this Friday’s Rethinking Clinical Trials Grand Rounds, Jon Tilburt of the Mayo Clinic in Arizona and Andrea Cheville of the Mayo Clinic in Minnesota will present “Initial Outcomes of the NOHARM Pragmatic Trial.”

The Grand Rounds session will be held on Friday, July 25, 2025, at 1:00 pm eastern.

NOHARM, an NIH Collaboratory Trial, is testing the use of EHR-embedded tools consisting of patient- and clinician-facing decision support components that enable patients to integrate nonpharmacologic pain care into their perioperative management.

Tilburt and Cheville are the principal investigators of NOHARM. Tilburt is a professor of medicine at the Mayo Clinic in Arizona, and Cheville is a professor of physical medicine and rehabilitation at the Mayo Clinic in Minnesota.

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July 15, 2025: ClinicalTrials.gov and the State of Clinical Trials, in This Week’s Rethinking Clinical Trials Grand Rounds

Headshots of Adrian Hernandez and Rebecca Sullenger
Adrian Hernandez and Rebecca Sullenger

In this Friday’s Rethinking Clinical Trials Grand Rounds, Adrian Hernandez and Rebecca Sullenger of Duke University will present “State of Clinical Trials: An Analysis of ClinicalTrials.gov.”

They will be joined by a discussion panel that will include Sara Bristol Calvert of the Clinical Trials Transformation Initiative (CTTI) and Karen Chiswell and Christopher J. Lindsell of Duke University.

The Grand Rounds session will be held on Friday, July 18, 2025, at 1:00 pm eastern.

Hernandez, who serves as co–principal investigator of the NIH Pragmatic Trials Collaboratory Coordinating Center, is a professor of medicine and vice dean in the Duke University School of Medicine and executive director of the Duke Clinical Research Institute (DCRI). Sullenger is an MD student in the Duke University School of Medicine. Calvert is director of projects at CTTI, Chiswell is a statistical scientist at the DCRI, and Lindsell is the director of data science and biostatistics at the DCRI.

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July 9, 2025: Novel Recruitment of Clinical Sites in the AIM-Back Pragmatic Trial, in This Week’s Rethinking Clinical Trials Grand Rounds

Headshots of Tyler Cope and Trevor Lentz
Dr. Tyler Cope and Dr. Trevor Lentz

In this Friday’s Rethinking Clinical Trials Grand Rounds, Tyler Cope and Trevor Lentz of the Duke Clinical Research Institute will present “Novel Approaches to Recruiting Clinical Sites for Embedded Pragmatic Clinical Trials: Insights From the AIM-back Trial.”

The live webinar will be held on Friday, July 11, 2025, at 1:00 pm eastern.

Cope is a clinical research associate at the Duke Clinical Research Institute and Lentz is an associate professor of orthopaedic surgery at Duke University.

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June 25, 2025: The BETTER CARE-HF Pragmatic Trial, in This Week’s Rethinking Clinical Trials Grand Rounds

Headshot of Dr. Amrita Mukhopadhyay
Dr. Amrita Mukhopadhyay

In this Friday’s Rethinking Clinical Trials Grand Rounds, Amrita Mukhopadhyay of the NYU Grossman School of Medicine will present “The BETTER CARE-HF Study: A Pragmatic Cluster Randomized Trial to Improve Heart Failure Care.”

The live webinar will be held on Friday, June 27, 2025, at 1:00 pm eastern.

Mukhopadhyay is the Eugene Braunwald, MD, Assistant Professor of Cardiology at the NYU Grossman School of Medicine.

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June 18, 2025: The BedMed and BedMed-Frail Trials, in This Week’s Rethinking Clinical Trials Grand Rounds

Headshot of Dr. Scott Garrison
Dr. Scott Garrison

In this Friday’s Rethinking Clinical Trials Grand Rounds, Scott Garrison of the University of Alberta will present “The BedMed and BedMed-Frail Randomized Trials.” The trials compared bedtime vs morning administration of antihypertensive medications.

The live webinar will be held on Friday, June 20, 2025, at 1:00 pm eastern.

Garrison is a professor of family medicine at the University of Alberta and the director of the Pragmatic Trials Collaborative in Canada.

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June 4, 2025: The REDCap Advanced Randomization Module, in This Week’s Rethinking Clinical Trials Grand Rounds

Headshot of Dr. Jonathan Casey
Dr. Jonathan Casey

In this Friday’s Rethinking Clinical Trials Grand Rounds, Jonathan Casey of Vanderbilt University Medical Center will present “The REDCap Advanced Randomization Module: A Trial Innovation Network Project to Support the Needs of Modern Trials.”

The live webinar will be held on Friday, June 7, 2025, at 1:00 pm eastern.

Casey is an assistant professor of medicine, a co–principal investigator of the Vanderbilt Trial Innovation Center, and the director of the Pragmatic Critical Care Research Group Coordinating Center at Vanderbilt University Medical Center.

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May 30, 2025: Randomizing in Clinical Care in the KP-VACCINATE Megatrial, in This Week’s PCT Grand Rounds

Headshot of Dr. Ankeet BhattIn this Friday’s Rethinking Clinical Trials Grand Rounds, Ankeet Bhatt of the Kaiser Permanente Northern California Division of Research will present “Embedding Randomization Into Clinical Care in Learning Healthcare Systems: Insights From the KP-VACCINATE Megatrial.”

The Grand Rounds session will be held on Friday, May 30, 2025, at 1:00 pm eastern.

Bhatt is a cardiologist at the Kaiser Permanente San Francisco Medical Center, a research scientist at the Kaiser Permanente Northern California Division of Research, and an adjunct professor at the Stanford University School of Medicine.

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May 12, 2025: Clinical Trials in a New and Evolving World, in This Week’s PCT Grand Rounds

Headshots of Dr. Jeffrey Spaeder and Dr. Adrian HernandezIn this Friday’s Rethinking Clinical Trials Grand Rounds, Jeffrey Spaeder and Adrian Hernandez will present “Pivoting Clinical Trials Into a New and Evolving World.”

The Grand Rounds session will be held on Friday, May 16, 2025, at 1:00 pm eastern.

Spaeder is the chief medical and scientific officer at IQVIA. Hernandez, who serves as co–principal investigator of the NIH Pragmatic Trials Collaboratory Coordinating Center, is a professor of medicine and vice dean in the Duke University School of Medicine and executive director of the Duke Clinical Research Institute.

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May 7, 2025: Results of BackInAction Pragmatic Trial of Acupuncture in Low Back Pain, in This Week’s PCT Grand Rounds

Headshots of Dr. Andrea Cook, Dr. Lynn DeBar, and Dr. Patricia Herman
Dr. Andrea Cook, Dr. Lynn DeBar, and Dr. Paricia Herman

In this Friday’s PCT Grand Rounds, Andrea Cook, Lynn DeBar, and Patricia Herman will present “A Policy-Relevant Pragmatic Trial on Acupuncture Effectiveness for Low Back Pain in Older Adults: Clinical and Cost Outcomes and Lessons Learned.”

The Grand Rounds session will be held on Friday, May 9, 2025, at 1:00 pm eastern.

The speakers will present the results of BackInAction, an NIH Collaboratory Trial. BackInAction compared standard and advanced courses of acupuncture with usual care for older adults with chronic low back pain.

Cook is a senior biostatistics investigator at the Kaiser Permanente Washington Health Research Institute; DeBar is a distinguished investigator at the Kaiser Permanente Center for Health Research; and Herman is a senior behavioral scientist at RAND, codirector of the RAND Research Across Complementary and Integrative Health Institutions (REACH) Center, and a professor of policy analysis at the RAND School of Public Policy.

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