Grand Rounds

October 8, 2025: Engaging Rural Communities in Pragmatic Clinical Trials, in This Week’s Rethinking Clinical Trials Grand Rounds

Posted on by Sophia Ramirez

In this Friday's Rethinking Clinical Trials Grand Rounds, Julie Fritz of the University of Utah and Sebastian Tong of the University of Washington will present "Engaging Rural Communities in Pragmatic Clinical Trials: Leveraging the CARE for Health Initiative Hubs to Enhance Enrollment for BeatPain."

The Grand Rounds session will be held on Friday, October 10, 2025, at 1:00 pm eastern.

BeatPain Utah, an NIH Collaboratory Trial, is comparing the effectiveness of nonpharmacologic intervention strategies for patients with back pain seeking care in federally qualified health centers throughout the state of Utah.

Fritz is the principal investigator for BeatPain Utah and a distinguished professor of physical therapy and athletic training at the University of Utah. Tong is a co–principal investigator for AIM-CP, an NIH Collaboratory Trial, and an associate professor of family medicine at the University of Washington.

Join the online meeting.

October 1, 2025: Lessons From the PIpELINe Trial in Myocardial Infarction, in This Week’s Rethinking Clinical Trials Grand Rounds

Posted on by Damon Seils

Headshot of Dr. Elisabetta TonetIn this Friday’s Rethinking Clinical Trials Grand Rounds, Elisabetta Tonet of the Azienda Ospedaliero–Universitaria di Ferrara will present “Multi-Domain Rehabilitation for Older Patients With Myocardial Infarction: The PIpELINe Trial.”

The Grand Rounds session will be held on Friday, October 3, 2025, at 1:00 pm eastern.

Tonet is a cardiology consultant in the Cardiology Unit of the Azienda Ospedaliero–Universitaria di Ferrara.

Join the online meeting.

September 24, 2025: P Values vs Decision-Maker Perspectives, in This Week’s Rethinking Clinical Trials Grand Rounds

Posted on by Damon Seils

In a special session of Rethinking Clinical Trials Grand Rounds on September 26, longtime leaders from the NIH Pragmatic Trials Collaboratory will present “Significance in Pragmatic Clinical Trials: P Values vs Decision-Maker Perspectives.”

The Grand Rounds session will be held on Friday, September 26, 2025, at 1:00 pm eastern.

Greg Simon is a senior investigator at the Kaiser Permanente Washington Health Research Institute, a member of the NIH Collaboratory leadership team, and a cochair of the NIH Collaboratory’s Health Care Systems Interactions Core. Susan Huang is a Chancellor’s Professor in the Division of Infectious Diseases at the UC Irvine School of Medicine and the medical director of epidemiology and infection prevention at UCI Health. She was the principal investigator for ABATE Infection, an NIH Collaboratory Trial. Liz Turner is an associate professor of biostatistics and bioinformatics and global health at Duke University and a cochair of the NIH Collaboratory’s Biostatistics and Study Design Core.

Join the online meeting.

September 17, 2025: Lessons From the REMAP-CAP Trial in Europe, in This Week’s Rethinking Clinical Trials Grand Rounds

Posted on by Damon Seils

Headshot of Denise van HoutIn this Friday’s Rethinking Clinical Trials Grand Rounds, Denise van Hout of University Medical Center Utrecht will present “Hurdles for the Delivery of Trials: Insights From the Randomized Embedded Multifactorial Adaptive Platform Trial on Community-Acquired Pneumonia (REMAP-CAP) in Europe.”

The Grand Rounds session will be held on Friday, September 19, 2025, at 1:00 pm eastern.

van Hout is a postdoctoral researcher in the Julius Center for Health Sciences and Primary Care at University Medical Center Utrecht.

Join the online meeting.

September 10, 2025: Initial Outcomes of OPTIMUM, in This Week’s Rethinking Clinical Trials Grand Rounds

Posted on by Damon Seils

Headshots of Drs. Natalia Morone, Carol Greco, and Kim FaurotIn this Friday’s Rethinking Clinical Trials Grand Rounds, Natalia Morone, Carol Greco, and Kim Faurot will present “Initial Outcomes of the Optimizing Pain Treatment in Medical Settings Using Mindfulness (OPTIMUM) Pragmatic Trial.”

The Grand Rounds session will be held on Friday, September 12, 2025, at 1:00 pm eastern.

OPTIMUM, an NIH Collaboratory Trial, is studying the addition of mindfulness-based stress reduction to usual care for patients with chronic low back pain, compared with usual care alone, with the goal of improving pain outcomes and reducing opioid prescriptions. Learn more about OPTIMUM.

Morone, the principal investigator for OPTIMUM, is an associate professor of medicine at Boston University and a clinical general internist at Boston Medical Center. Greco is an associate professor of psychiatry and psychical therapy at the University of Pittsburgh. Faurot is an assistant professor of physical medicine and rehabilitation at the University of North Carolina at Chapel Hill.

Join the online meeting.

September 8, 2025: P Values vs Decision-Maker Perspectives, in a Special Grand Rounds Session on September 26

Posted on by Damon Seils

In a special session of Rethinking Clinical Trials Grand Rounds on September 26, longtime leaders from the NIH Pragmatic Trials Collaboratory will present “Significance in Pragmatic Clinical Trials: P Values vs Decision-Maker Perspectives.”

The Grand Rounds session will be held on Friday, September 26, 2025, at 1:00 pm eastern.

Greg Simon is a senior investigator at the Kaiser Permanente Washington Health Research Institute, a member of the NIH Collaboratory leadership team, and a cochair of the NIH Collaboratory’s Health Care Systems Interactions Core. Susan Huang is a Chancellor’s Professor in the Division of Infectious Diseases at the UC Irvine School of Medicine and the medical director of epidemiology and infection prevention at UCI Health. She was the principal investigator for ABATE Infection, an NIH Collaboratory Trial. Liz Turner is an associate professor of biostatistics and bioinformatics and global health at Duke University and a cochair of the NIH Collaboratory’s Biostatistics and Study Design Core.

Join the online meeting.

 

September 3, 2025: The Non-Learning Health System, in This Week’s Rethinking Clinical Trials Grand Rounds

Posted on by Damon Seils

Graphic featuring a headshot of Dr. Rob CaliffIn this Friday’s Rethinking Clinical Trials Grand Rounds, Robert Califf of Duke University will present “The Non-Learning Health System.”

The Grand Rounds session will be held on Friday, September 5, 2025, at 1:00 pm eastern.

As a former US commissioner of food and drugs, Califf led the Food and Drug Administration from 2016 to 2017 and again from 2022 to 2025. Prior to his tenure at the FDA, Califf was a professor of medicine and the vice chancellor for clinical and translational research at Duke University. He was the founding director of the Duke Clinical Research Institute and the founding principal investigator for the NIH Pragmatic Trials Collaboratory. Califf was elected to membership in the National Academy of Medicine in 2016.

In the Grand Rounds session, Califf will discuss how academia adapts or dies in our new environment, as well as inspire us to embrace these changes as an opportunity to improve.

Join the online meeting.

August 26, 2025: Special September 5 Grand Rounds Will Feature Rob Califf on “The Non-Learning Health System”

Posted on by Damon Seils

Graphic featuring a headshot of Dr. Rob CaliffIn a special session of Rethinking Clinical Trials Grand Rounds on September 5, special guest Dr. Robert Califf will present “The Non-Learning Health System.”

The Grand Rounds session will be held on Friday, September 5, 2025, at 1:00 pm eastern.

As a former US commissioner of food and drugs, Califf led the Food and Drug Administration from 2016 to 2017 and again from 2022 to 2025. Prior to his tenure at the FDA, Califf was a professor of medicine and the vice chancellor for clinical and translational research at Duke University. He was the founding director of the Duke Clinical Research Institute and the founding principal investigator for the NIH Pragmatic Trials Collaboratory. Califf was elected to membership in the National Academy of Medicine in 2016.

In the Grand Rounds session, Califf will discuss how academia adapts or dies in our new environment, as well as inspire us to embrace these changes as an opportunity to improve.

Join the online meeting.

August 20, 2025: PCORnet Playbook Featured in This Week’s Rethinking Clinical Trials Grand Rounds

Posted on by Damon Seils

Emily O'Brien
Dr. Emily O’Brien

In this Friday’s Rethinking Clinical Trials Grand Rounds, Emily O’Brien of Duke University will present “The PCORnet Playbook: Avoiding the Fumble in Pragmatic Trials.”

The Grand Rounds session will be held on Friday, August 22, 2025, at 1:00 pm eastern.

O’Brien is an associate professor in population health sciences at Duke University. She serves as cochair of the NIH Collaboratory’s Patient-Centered Outcomes Core Working Group.

Join the online meeting.

August 6, 2025: Varenicline for Youth Nicotine Vaping Cessation, in This Week’s Rethinking Clinical Trials Grand Rounds

Posted on by Damon Seils

Headshot of Dr. Eden Evins
Dr. A. Eden Evins

In this Friday’s Rethinking Clinical Trials Grand Rounds, Eden Evins of Harvard Medical School will present “Varenicline for Youth Nicotine Vaping Cessation: A Randomized Clinical Trial.”

The Grand Rounds session will be held on Friday, August 8, 2025, at 1:00 pm eastern.

Evins is the Cox Family Professor of Psychiatry in the Field of Addiction Medicine and the founding director of the Center for Addiction Medicine at Harvard Medical School

Join the online meeting.