Health Care Systems Interactions
Overview
Chair:
Core goal: Support and facilitate productive collaboration between researchers, clinicians, and health system leaders to conduct effective, relevant embedded pragmatic clinical research.
The Core aims to generate generalizable knowledge on how to engender trusting, long-term partnerships so stakeholders are eager to participate in research and trust that their interests, including providing excellent care to patients, will be well served. In addition, the Core shares knowledge on conducting research in a way that does not disrupt the delivery of clinical care or health systems’ operations.
The Core works with the Collaboratory to identify and consult on challenges, provide a forum for discussion, and develop tools and best practices for research conducted in partnership with diverse healthcare systems. The Core’s activities are applicable throughout the life cycle of clinical trials.
Interview
During the NIH Pragmatic Trials Collaboratory 2024 Steering Committee meeting, Dr. Greg Simon discussed challenges and lessons learned in healthcare system engagement.
Areas of Focus
This page also includes products from the Stakeholder Engagement Core led by Sean Tunis, CMTP, from 2012-2017.
News and Interviews
- News_A Year of Trial Results and Innovations From the NIH Pragmatic Trials Collaboratory
December 15, 2025: A Year of Trial Results and Innovations From the NIH Pragmatic Trials Collaboratory
- Podcast 55_End-of-Trial Decision-Making
Podcast 55: End-of-Trial Decision-Making
- News_P Values vs Decision-Maker Perspectives, in a Special Grand Rounds Session on September 26
September 8, 2025: P Values vs Decision-Maker Perspectives, in a Special Grand Rounds Session on September 26
- Podcast 52_Making Pragmatic Clinical Trials More Pragmatic
Podcast 52: Making Pragmatic Clinical Trials More Pragmatic
- News_How to Choose Patient-Reported Outcome Measures in Pragmatic Clinical Trials
June 23, 2025: How to Choose Patient-Reported Outcome Measures in Pragmatic Clinical Trials?
- News_New Living Textbook Chapter Provides Guidance for Investigators Facing Tough Decisions After a Trial Ends
May 14, 2025: New Living Textbook Chapter Provides Guidance for Investigators Facing Tough Decisions After a Trial Ends
- News_NIH Collaboratory’s Greg Simon to Receive Inaugural HCSRN Founders’ Award
November 19, 2024: NIH Collaboratory’s Greg Simon to Receive Inaugural HCSRN Founders’ Award
- News_ JAMA Commentary Highlights Gap Between Research Results and Implementation Decisions
October 3, 2024: JAMA Commentary Highlights Gap Between Research Results and Implementation Decisions
- News_NIH Collaboratory Leaders Reflect on Healthcare System and Patient Engagement Challenges and Lessons Learned
August 5, 2024: NIH Collaboratory Leaders Reflect on Healthcare System and Patient Engagement Challenges and Lessons Learned
- News_A Year of New Insights From the NIH Pragmatic Trials Collaboratory
December 12, 2023: A Year of New Insights From the NIH Pragmatic Trials Collaboratory
Products and Publications
- NIHPTCollab_CommunicatingwHSP_figure_19mar2025
Communicating With Health System Partners During The Lifecycle Of A Trial
- Curtis et al Contemp Clin Trials 2025
Monitoring in pragmatic trials lessons from the NIH Pragmatic Trials Collaboratory
- Boyd et al J Am Med Inform Assoc 2023
Potential bias and lack of generalizability in electronic health record data: reflections on health equity from the National Institutes of Health Pragmatic Trials Collaboratory
- Palazzo et al Am J Manag Care 2022
A value proposition for pragmatic clinical trials
- Richesson et al J Am Med Inform Assoc 2021
Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory
- NIHPTCollab_ePCT-QSG-HCSL
ePCT Quick Start Guide for Researcher and Healthcare Systems Leader Partnerships
- Tuzzio et al Healthcare 2021
Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies
- HCS_Core_FAQ_Resource
Resources for Frequently Asked Questions from the Health Care Systems Interactions Core
- Tuzzio and Larson eGEMs 2019
The promise of pragmatic clinical trials embedded in learning health systems
- Tuzzio et al Healthc (Amst) 2018
Pragmatic clinical trials offer unique opportunities for disseminating, implementing, and sustaining evidence-based practices into clinical care: Proceedings of a workshop
Presentations
- Health Care Systems Interactions Slides OCT2025
Onboarding Meeting Oct. 29, 2025 - HCS Interactions Core Intro
- Health Care Systems Interactions Slides 28OCT2025
Onboarding Meeting Oct. 28, 2025 - HCS Interactions Core Intro
- GR-Video-09-26-25
Significance in ePCTs: P Values vs Decision-Maker Perspectives
- GR-Slides-09-26-25
Significance in ePCTs: P Values vs Decision-Maker Perspectives
- 00_Simon_P Values_Approved_combined_DONE
Significance in ePCTs: P Values vs Decision-Maker Perspectives
- HCS Interactions Core Slides JAN2025
Onboarding Meeting Jan 2025 - HCS Interactions Core Intro
- HCS Interactions Core Slides NOV2024
Onboarding Meeting Nov 2024 - HCS Interactions Core Intro
- HCSRN Presentation_FINAL_ASD_Palazzo 22Feb2023
Should I Stay, or Should I Go? Results, Engagement, and End of Trial Decision Making
- 2019 AcademyHealth Workshop_Tuzzio
Engaging Stakeholders and Aligning with Health System Partners
- SC-Mtg-2022-Day-2-Larson
Patient, Clinician, and Healthcare System Engagement Panel at 2022 Steering Committee Meeting