The NIH Pragmatic Trials Collaboratory is pleased to announce the latest resource as part of its Quick Start Guide series. These Quick Start Guides are intended to support the successful conduct of embedded pragmatic clinical trials (ePCTs). The ePCT Quick Start Guide for Project Managers links to resources for project managers to support the conduct of ePCTs within healthcare systems.

The guides serve as annotated tables of contents, pointing readers to essential content in the Living Textbook to help successfully launch an ePCT and partner with healthcare systems leaders. They also link to recommended readings, documentation checklists, research toolkits, study documents, regulatory documents, oversight documents, and additional resources.

“We are excited to share this new tool with the research community,” said Tammy Reece, project director for the NIH Collaboratory Coordinating Center. “Pragmatic trials can pose unique challenges even for experienced project managers. Our hope is that this guide will serve as a useful resource throughout the entire life cycle of ePCTs—from planning through completion.”

The Quick Start Guide for Investigators is designed for clinical investigators interested in learning how to conduct an ePCT. The Quick Start Guide for Researcher and Healthcare Systems Leader Partnerships is designed to help clinical investigators partner with healthcare system leaders to support the successful conduct on an ePCT.