INSPIRE

January 24, 2023: INSPIRE Intervention Goes Live, Will Use Predictive Algorithm to Reduce Unnecessary Antibiotic Prescribing

Posted on by Damon Seils
Headshot of Dr. Shruti Gohil
Dr. Shruti Gohil

The INSPIRE NIH Collaboratory Trial went live this month, with a new order entry screen being activated in the electronic health record at 51 hospital sites randomized to the intervention.

Congratulations to lead investigator Dr. Shruti Gohil, co–principal investigators Dr. Susan Huang and Dr. Richard Platt, and the INSPIRE team!

INSPIRE is studying the effectiveness of a personalized clinical decision support program in improving antibiotic prescribing for non–critically ill patients hospitalized with abdominal infections or skin and soft tissue infections. The trial is comparing routine care under hospital-based antibiotic stewardship programs with an enhanced program that adds a predictive algorithm to reduce unnecessary prescribing of extended-spectrum antibiotics.

The computerized provider order entry system at sites in the intervention group prompts physicians when the antibiotic they select is discordant with the estimated need for that antibiotic. The 18-month study will evaluate approximately 53,000 patients with abdominal infections and approximately 37,000 patients with skin or soft tissue infections.

Headshot of Dr. Susan Huang
Dr. Susan Huang
Headshot of Dr. Richard Platt
Dr. Richard Platt

Learn more about INSPIRE.

INSPIRE is supported within the NIH Pragmatic Trials Collaboratory by a grant from the National Institute of Allergy and Infectious Diseases (NIAID).

November 29, 2022: INSPIRE NIH Collaboratory Trial Joins the NIH Pragmatic Trials Collaboratory

Posted on by Damon Seils
Headshot of Dr. Shruti Gohil
Dr. Shruti Gohil

The NIH Pragmatic Trials Collaboratory is excited to welcome the INSPIRE NIH Collaboratory Trial to its portfolio of innovative, large-scale pragmatic clinical trials embedded in healthcare systems.

INSPIRE (or Intelligent Stewardship Prompts to Improve Real-Time Empiric Antibiotic Selection for Patients) will implement the INSPIRE-ASP Trials for Abdominal and Skin and Soft Tissue Infections. These 2 cluster randomized trials will study the effectiveness of a personalized clinical decision support program in improving antibiotic prescribing for non–critically ill patients who are hospitalized with abdominal infections or skin and soft tissue infections.

Although fewer than 5% of such patients have an antibiotic-resistant infection, more than half receive extended-spectrum antibiotics. Tools to support clinicians in judicious antibiotic prescribing are needed to curb the urgent public health threat of antibiotic resistance. According to the Centers for Disease Control and Prevention, more than 2.8 million antimicrobial-resistant infections occur each year in the United States alone, and more than 35,000 people die as a result.

Dr. Shruti Gohil will serve as INSPIRE’s lead investigator. Gohil is an assistant professor of medicine at the University of California, Irvine, and associate medical director of epidemiology and infection prevention at UCI Health. Dr. Susan Huang, professor of medicine at UC Irvine, and Dr. Richard Platt, professor and chair of population medicine at the Harvard Pilgrim Health Care Institute, are the co–principal investigators for the project.

Headshot of Dr. Susan Huang
Dr. Susan Huang
Headshot of Dr. Richard Platt
Dr. Richard Platt

The INSPIRE NIH Collaboratory Trial is supported within the NIH Pragmatic Trials Collaboratory by a grant from the National Institute of Allergy and Infectious Diseases (NIAID).

Huang and Platt are experienced investigators in the NIH Collaboratory. Huang was principal investigator of the ABATE Infection NIH Collaboratory Trial. Platt is a member of the program’s Coordinating Center leadership and cochair of the Distributed Research Network.

Learn more about the NIH Collaboratory Trials.