May 4, 2026: New Podcast Episode Considers Impact of New Digital Technologies on Pragmatic Trial Design

In a new episode of the Rethinking Clinical Trials Podcast, Majid Afshar and Mary Ryan Baumann of the University of Wisconsin-Madison expanded on key takeaways from their recent Grand Rounds presentation, “A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence (AI) to Improve Health Practitioner Well-Being.”

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The need to document patient visits in the electronic health record is a driver of clinician burnout. The research team sought to assess whether the use of an ambient AI scribe could improve clinician well-being by automating the documentation process. In the podcast, Afshar and Ryan Baumann reflected on some of the forces that guided their trial design.

“The technology itself is in silo, right? The speech-to-text and text-to-speech and [large language models] are very good,” said Afshar. “I think the challenge is actually adapting it to the human use case… We spent a lot of time with our human factors engineering implementation scientists to make sure that the training and onboarding and the use of the tool was appropriate for given end users.”

According to Afshar, this predeployment step led to a fidelity rate of over of 70%.

Once the research team began collecting data, the combination of new digital technologies and a pragmatic setting posed its own set of challenges.

“The pure amount of information that’s coming from each participant is astounding,” said Baumann. “It’s not on a scale that you can look at each individual data point and necessarily understand: Is this an outlier? Did something weird happen on this one day? What are the other elements and factors within a health system that’s still operating as it normally does?”

Ultimately, the research team found a 20% reduction in burnout and a trend towards improvement in professional fulfillment. UW Health scaled the project from 66 to over 600 licenses.

Afshar is an associate professor and director of learning health systems in the Departments of Medicine and Biostatistics & Medical Informatics. Baumann is an assistant professor in the Departments of Population Health Sciences and Biostatistics & Medical Informatics.

Grand Rounds January 30, 2026: A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being (Majid Afshar, MD, MS; Mary Ryan Baumann, PhD)

Speakers

Majid Afshar, MD, MS
Associate Professor
Director, Learning Health Systems
Departments of Medicine and Biostatistics & Medical Informatics
University of Wisconsin-Madison

Mary Ryan Baumann, PhD
Assistant Professor
Departments of Population Health Sciences and Biostatistics & Medical Informatics
University of Wisconsin-Madison

Keywords

Artificial Intelligence; Burnout; Provider Well-Being; Learning Health System

Key Points

  • Documentation in the Electronic Health Record (EHR) is a driver of clinician burnout; it can reduce their capacity to connect with patients during an appointment and spill over into daily life, i.e. “work outside of work.” The research team sought to assess whether the use of an ambient Artificial Intelligence (AI) scribe could improve clinician well-being by automating the documentation process.
  • The stepped-wedge, individually randomized trial took place over 24 weeks at UW Health. 66 providers across various specialties were randomized to receive access to ambient AI at Week 1, Week 7, or Week 13. The primary endpoint was physician well-being, measured by the Professional Fulfillment subscale and a burnout composite.
  • The research team found a 20% reduction in burnout and a trend towards improvement in professional fulfillment. These effects were sustained over the course of the trial. Use of the technology also decreased “work outside of work” by an average of 30 minutes and “time in notes” by 21 minutes.

Discussion Themes

Qualitative interviews found that patients of the clinicians in the trial appreciated the reduced computer interaction and felt that communication was clearer and more open.

The research team worked with the EHR company to develop a rubric for evaluating the AI-generated notes for accuracy, i.e. the presence of AI hallucinations or falsifications.

Following the trial’s success, UW Health scaled the project from 66 to over 600 licenses. An operational dashboard was developed for real-time monitoring of utilization and documentation metrics to ensure sustained performance and coding compliance.