October 29, 2025 Virtual Onboarding Meeting: CARNATION

NIH Pragmatic Trials Collaboratory Onboarding Meeting

October 29, 2025
Virtual

Purpose

Welcome and hear from our new NIH Collaboratory Trial; provide introductions and an overview of the NIH Pragmatic Trials Collaboratory; hear from the Core Working Groups; and engage in discussion.

Welcome and Opening Remarks
Lesley Curtis
Wendy Weber*

Overview of the NIH Pragmatic Trials Collaboratory
Lesley Curtis
Wendy Weber*

Working With the NIH Collaboratory Coordinating Center
Kevin Weinfurt

Get to Know the New UG3 NIH Collaboratory Trial 
Coordinated cARe paiN mAnagement Technology ImplementatiON (CARNATION)
Lynn DeBar
Rachel Gold
Nicole Cook

Introduction to the Core Working Groups

 

Closing Remarks
Kevin Weinfurt
Wendy Weber*

 

*Unable to attend the onboarding meeting due to the federal government shutdown.

November 10, 2025: NIH Pragmatic Trials Collaboratory Welcomes New Trials CARNATION and EquiP PC

We are excited to add 2 new NIH Collaboratory Trials to our portfolio of innovative pragmatic clinical trials embedded in healthcare systems.

CARNATION and EquiP PC are supported by the National Institute of Neurological Disorders and Stroke through the Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) program, a component of the Helping to End Addiction Long-Term Initiative℠, or NIH HEAL Initiative℠, to address the opioid crisis.

Headshots of Dr. Lynn DeBar, Dr. Rachel Gold, and Dr. Nicole Cook
Dr. Lynn DeBar, Dr. Rachel Gold, and Dr. Nicole Cook, principal investigators for CARNATION

CARNATION (Coordinated Care Pain Management Technology Implementation) will partner with a national network of community health centers to test a multicomponent implementation support intervention designed to enable community health centers’ systematic use of electronic health record technologies for coordinating primary care–based pain care that is congruent with integrative pain management. This type 3 hybrid effectiveness-implementation trial will generate urgently needed empirical evidence for how to make integrative pain management strategies available in community health centers, where limited resources present barriers to the delivery and coordination of such care.

Lynn DeBar, Rachel Gold, and Nicole Cook will serve as the co–principal investigators of the CARNATION trial. DeBar, who led the NIH Collaboratory Trials BackInAction and PPACT, is a distinguished investigator at the Kaiser Permanente Center for Health Research. Gold is a senior investigator and the program director of chronic disease, preventive health, and wellness at OCHIN. Cook is also a research investigator at OCHIN.

Headshots of Dr. Kari Stephens and Dr. Rodger Kessler
Dr. Kari Stephens and Dr. Rodger Kessler, principal investigators for EquiP PC

EquiP PC (Equitable Primary Care for Pain Care) will test the effectiveness of an adapted behavioral health integration toolkit to improve chronic pain care. The trial will assess outcomes such as reduced pain interference, improved integrated behavioral health, implementation success, and access to care with the goal of expanding access to high-quality, team-based chronic pain care in primary care settings.

The co–principal investigators of EquiP PC are Kari Stephens and Rodger Kessler. Stephens is a licensed clinical psychologist and a professor in family medicine at the University of Washington. Kessler is vice president for innovation at the DARTNet Institute.

These 2 new NIH Collaboratory Trials will extend the mission of the NIH Pragmatic Trials Collaboratory to strengthen the national capacity to implement cost-effective, large-scale research studies that engage healthcare delivery organizations as research partners. To date, the program has supported 36 NIH Collaboratory Trials covering a range of clinical areas and spanning a dozen NIH Institutes and Centers.