The NIA IMPACT Collaboratory will publish a request for applications for pilot grants on August 16, 2021, with letters of intent due September 17, 2021. More information is available on the IMPACT Collaboratory website. The 1-year pilot grant awards will likely be eligible for funding of up to $175,000 in direct costs. The awards will support pilot ...

Leaders of the ACTIV-6 study, featured recently during NIH Collaboratory Grand Rounds, will hold a town hall Wednesday, June 9, to share information about the study with interested stakeholders, including sites and investigators that may want to participate. The leadership team will describe the rationale for ACTIV-6, share an overview of the platform and objectives, ...

In the latest episode of the NIH Collaboratory Grand Rounds podcast, Dr. Megan Ranney and Dr. Adrian Hernandez continue the discussion about using digital technologies in clinical trials and best practices for online participant recruitment. The full May 7 Grand Rounds webinar with Dr. Ranney is also available.

The NIH Collaboratory is using its popular ePCT Grand Rounds platform for a special webinar series on diversity in pragmatic clinical trials. In this Friday’s session—“Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize Diversity”—Dr. Wendy Weber of the National Center for Complementary and Integrative Health will host investigators from 2 of the NIH ...

The Health Care Systems Research Network (HCSRN), in partnership with the NIH Health Care Systems Research Collaboratory, presented a virtual workshop on Essentials of Embedded Pragmatic Clinical Trials (ePCTs) on May 11-12, 2021. The sessions introduced concepts in the design, conduct, and implementation of ePCTs, with a particular focus on methods relevant to health services ...

Recently published results of the ADAPTABLE study demonstrate no difference in rates of death, hospitalization for heart attack or stroke, or bleeding in those who were assigned to high- versus low-dose aspirin (325 mg versus 81 mg). Trial participants frequently switched their dose, which may have biased the results toward the null: 41.6% of patients ...

In this Friday’s COVID-19 Grand Rounds session, Dr. Chris Butler of Oxford University and Dr. Ben Saville of Berry Consultants will present “The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and Delivery.” The Grand Rounds session will be held on Friday, May 21, at 1:00 pm eastern. Join the ...

Longtime NIH Collaboratory researcher Dr. Vincent Mor received Brown University’s Susan Colver Rosenberger Medal of Honor, the highest honor the university’s faculty can bestow, during commencement celebrations on May 2. One of 2 recipients this year and among only 33 honorees since the award was established in 1919, Mor was recognized for his service, leadership, and ...

The Helping to End Addiction Long-Term Initiative℠, or NIH HEAL Initiative℠, has launched an online communication and collaboration space, the Moving HEAL Research into Action Idea Exchange, to collect information that will shape the future of the initiative’s research on pain and addiction. Researchers, healthcare providers, and other stakeholders in the opioid crisis are encouraged to register ...

The Group-Based Mindfulness for Patients With Chronic Low Back Pain in the Primary Care Setting (OPTIMUM) trial has begun enrollment of study participants. The trial is part of the first cohort of the NIH Collaboratory’s Demonstration Projects to be supported through the NIH Heal Initiative’s PRISM program. Congratulations to principal investigator Dr. Natalia Morone and the OPTIMUM ...

The NIH Collaboratory this Friday, May 14, will use its popular ePCT Grand Rounds platform to launch a special workshop series on diversity in pragmatic clinical trials. Dr. Clyde Yancy of Northwestern University will begin the series with a keynote address, “Diverse Representation Among Clinical Trial Participants: Why It Is Important and How We Can Improve.” ...

The NIA IMPACT Collaboratory will publish a request for applications for pilot grants on August 16, 2021, with letters of intent due September 17, 2021. More information is available on the IMPACT Collaboratory website. The 1-year pilot grant awards will likely be eligible for funding of up to $175,000. The awards will support pilot projects that aim ...

In this Friday’s COVID-19 Grand Rounds session, Dr. Megan Ranney of Brown University will present “Online Recruitment in the Era of COVID-19: Pitfalls and Progress.” The Grand Rounds session will be held on Friday, May 7, at 1:00 pm eastern. Join the online meeting. Dr. Ranney is a practicing emergency physician, researcher, and advocate for innovative ...

The Healthcare Worker Exposure Response & Outcomes (HERO) Registry and the HERO-TOGETHER study are now open to anyone who lives, works, or interacts with healthcare workers in their households or anyone in the surrounding community. The HERO program enables participants to share their experiences after receiving a COVID-19 vaccine, contribute to the science, and help ...

The Nonpharmacologic Options in Postoperative Hospital-Based and Rehabilitation Pain Management (NOHARM) trial has begun enrollment of study participants. The trial is among the first of the NIH Collaboratory’s Demonstration Projects to be supported through the NIH Heal Initiative’s PRISM program. Congratulations to co–principal investigators Drs. Andrea Cheville and Jon Tilburt and the NOHARM team! The PRISM projects—Pragmatic ...

In this week’s COVID-19 Grand Rounds session, Dr. Susanna Naggie of Duke University and Dr. Elizabeth Shenkman of the University of Florida will present “ACTIV-6: A Direct-to-Participant Platform Trial of Repurposed Drugs for COVID-19 in Non-hospitalized Patients.” The Grand Rounds session will be held on Friday, April 30, at 1:00 pm eastern. Join the online ...

Registration for the 2021 Health Care Systems Research Network (HCSRN) Conference will close on Monday, May 3. The NIH Collaboratory is partnering with HCSRN to offer a workshop at the conference, which will be held virtually on May 11 and 12. The workshop, Essentials of Embedded Pragmatic Clinical Trials (ePCTs), will provide an introduction to investigative ...

On April 14 and 15, 2021, more than 100 participants joined the online Steering Committee meeting to discuss important considerations for Collaboratory trials and the embedded pragmatic clinical trial ecosystem at large, including adaptations made due to COVID-19, data sharing models and experiences, barriers encountered, and lessons learned. All presentations are available for download.

In this week’s COVID-19 Grand Rounds session, Dr. Samuel Brown of Intermountain Healthcare and the University of Utah will present “COVID Clinical Trials: The Intermountain Healthcare Experience.” The Grand Rounds session will be held on Friday, April 23, at 1:00 pm eastern. Join the online meeting. The NIH Collaboratory Coordinating Center is using its popular Grand ...

The NIH Health Care Systems Research Collaboratory will launch a special workshop series next month to explore and promote strategies for the inclusion of diverse participants in pragmatic clinical trials. The webinar series, Inclusion of Diverse Participants in Pragmatic Clinical Trials, will kick off on Friday, May 14, at 1:00 pm ET with a keynote presentation ...

In the latest episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez and Dr. Susan Ellenberg continue their discussion about the challenges of DSMBs and COVID-19 trials. The full March 5 Grand Rounds webinar with Dr. Ellenberg is also available.

In this week’s COVID-19 Grand Rounds session, Dr. Derek Angus of the University of Pittsburgh will present “Lessons From COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform Trial.” The Grand Rounds session will be held on Friday, April 2, at 1:00 pm eastern. Join the online meeting. The NIH Collaboratory Coordinating Center is using ...

The Health Care Systems (HCS) Interactions Core of the NIH Collaboratory has created a new guidance document: Resources for Frequently Asked Questions. The document compiles common questions from researchers and points to resources that provide potential solutions, including Living Textbook chapters and journal articles. The topics include evaluation strategies, anticipating and adapting to changes, dissemination ...

In an analysis of data collected as part of EMBED, an NIH Collaboratory Demonstration Project, the rate of opioid overdose visits per 100 all-cause visits to emergency departments rose nearly 30% in 2020. The absolute number of opioid overdose visits increased by more than 10%, even while visits for other life-threatening conditions declined. The findings ...

The Fibromyalgia TENS in Physical Therapy Study (FM-TIPS) has begun enrollment of study participants. It is the first study supported through the NIH Heal Initiative’s PRISM program to begin enrollment. Congratulations to co–principal investigators Drs. Kathleen Sluka and Leslie Crofford and the FM-TIPS team! The PRISM projects—Pragmatic and Implementation Studies for the Management of Pain to Reduce ...

To better understand efforts at cultural and linguistic adaptions in clinical trials focused on pain, members of the NIH Collaboratory’s Patient-Centered Outcomes Core recently conducted a survey of the PRISM NIH Collaboratory Trials (Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing), which are part of NIH’s Helping to End Addiction ...

In this week’s COVID-19 Grand Rounds session, Dr. Emily O’Brien of Duke University and Dr. Robert Califf of Verily Life Sciences and Google Health will present “HERO—Learning Together About Vaccines for SARS-CoV-2.” The Duke Clinical Research Institute and Verily are using the Healthcare Worker Exposure Response & Outcomes (HERO) Registry and its community of participants ...

A collaborative care intervention for injured patients at trauma centers can reduce symptoms of posttraumatic stress disorder (PTSD), according to the results of the Trauma Survivors Outcomes and Support (TSOS) study. The results were published online this week in JAMA Surgery. The TSOS study, an NIH Collaboratory Demonstration Project, was a stepped-wedge, cluster randomized pragmatic clinical ...

In this week’s COVID-19 Grand Rounds session, Drs. Mohamed Bassyouni and Jintanat Ananworanich of the Bill and Melinda Gates Medical Research Institute will present “Lessons Learned From the Gates MRI Virtual COVID-19 Trial.” The Grand Rounds session will be held on Friday, March 12, at 1:00 pm eastern. Join the online meeting. The NIH Collaboratory Coordinating ...

In the latest episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez and Dr. Kevin Schulman continue the discussion about strategies to promote COVID-19 vaccination. The full February 19 Grand Rounds webinar with Dr. Schulman is also available.

In this week’s COVID-19 Grand Rounds session, Dr. Susan Ellenberg of the University of Pennsylvania, will present “Data and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The Challenges.” The Grand Rounds session will be held on Friday, March 5, at 1:00 pm eastern. Join the online meeting. The NIH Collaboratory Coordinating Center is using its ...

The incidence of a specific type of “prescribing cascade” among patients with Alzheimer disease is low, according to a new analysis of data from the NIH Collaboratory Distributed Research Network (DRN). The study was published in the Journal of the American Geriatrics Society. Persons with Alzheimer disease are at high risk for prescribing cascades, in which ...

In this week’s COVID-19 Grand Rounds session, Dr. Kevin Schulman of Stanford University will present “Beyond Politics: Promoting COVID Vaccination in the US.” The Grand Rounds session will be held on Friday, February 19, at 1:00 pm eastern. Join the online meeting. The NIH Collaboratory Coordinating Center is using its popular Grand Rounds platform to share ...

A new section has been added to the Living Textbook chapter Dissemination Approaches for Different Stakeholders that offers practical strategies and tools for sharing study findings with healthcare system partners—beyond the usual journal publications and professional conferences. Suggestions include how to plan for impact at the outset, methods for communicating findings, and ideas for creating ...

The NIA IMPACT Collaboratory has announced 3 new funding opportunities for researchers at all levels who are interested in pragmatic clinical trials embedded in healthcare systems (ePCTs). They include funding for NIH Collaboratory Trials, a new scholars program for junior and senior investigators, and a new cycle of funding for 1-year pilot studies. NIH Collaboratory Trials ...

Meeting minutes, supplementary materials, and updates are available that summarize recent discussions related to the ethics and regulatory issues associated with the six PRISM NIH Collaboratory Trials: In the UG3 planning phase, the trials include BeatPain Utah and GRACE In the UH3 implementation phase, the trials include BackInAction, FM TIPS, NOHARM, and OPTIMUM These discussions, which took place ...

The NIH Collaboratory is partnering with the Health Care Systems Research Network (HCSRN) to offer a workshop at the 2021 HCSRN Conference, which will be held virtually on May 11 and 12. The workshop, Essentials of Embedded Pragmatic Clinical Trials (ePCTs), will provide an introduction to investigative opportunities for pragmatic clinical trials embedded in healthcare systems, ...

In this week’s COVID-19 Grand Rounds session, Dr. Renato Lopes of Duke University and the Brazilian Clinical Research Institute, will present “Generating High-Quality Evidence During a Pandemic: The Brazilian COALITION Experience.” The Grand Rounds session will be held on Friday, February 5, at 1:00 pm eastern. Join the online meeting. The NIH Collaboratory Coordinating Center is ...

In this week’s COVID-19 Grand Rounds session, Dr. Gregory Marcus of the University of California, San Francisco, will present “The COVID-19 Citizen Science Study.” The Grand Rounds session will be held on Friday, January 29, at 1:00 pm eastern. Join the online meeting. The Citizen Science Study is using a smartphone-based research platform to engage “citizen ...

In the latest episode of the NIH Collaboratory Grand Rounds podcast, Dr. Adrian Hernandez and Dr. Emily O’Brien continue the discussion about the HERO-TOGETHER initiative that aims to understand how healthcare workers do after receiving the COVID-19 vaccination. The full January 8 Grand Rounds webinar with Dr. O’Brien is also available.

The NIA IMPACT Collaboratory has announced that it will publish a request for applications for large-scale pragmatic clinical trials embedded in healthcare systems to test the effectiveness of care delivery intervention programs for people living with Alzheimer disease and related dementias and/or their care partners. The funding opportunity is expected to be announced in February. More ...

Many of the NIH Collaboratory NIH Collaboratory Trials use data from claims and research-identifiable files from the Centers for Medicare and Medicaid Services (CMS) to support their research. We have enhanced the Living Textbook and added new sections to better present the wealth of information on how to acquire, use, and link CMS data for ...

In this week’s COVID-19 Grand Rounds session, Dr. Pamela Tenaerts of the Clinical Trials Transformation Initiative will present “How CTTI & the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic.” The Grand Rounds session will be held on Friday, January 15, at 1:00 pm eastern. Join the online meeting. The NIH ...

Want to know more about the goals and challenges of the NIH Collaboratory’s PRISM NIH Collaboratory Trials? New downloadable handouts summarize the study aims, implementation lessons, and recent presentations from these innovative embedded pragmatic clinical trials (ePCTS). The 2-page study snapshots are accessible from each NIH Collaboratory Trial page and the links below: BackInAction: Pragmatic Trial of ...

In this week’s COVID-19 Grand Rounds session, Dr. Emily O’Brien of Duke University will present “HERO-Together: Building Vaccine Confidence With Long-Term Outcomes Data.” The Grand Rounds session will be held on Friday, January 8, at 1:00 pm eastern. Join the online meeting. HERO-Together is a long-term safety study of the COVID-19 vaccine developed by Pfizer and ...

We are pleased to announce our new collection of short educational videos that highlight advances in the use of electronic health records (EHRs) in pragmatic clinical trials. The videos are drawn from our 2020 EHR Workshop Grand Rounds Series, “Advances at the Intersection of Digital Health, Electronic Health Records and Pragmatic Clinical Trials.” The series ...

The NIA IMPACT Collaboratory is inviting applications from early- and mid-career researchers for its first annual training workshop and retreat, “Building Skills to Conduct Embedded Pragmatic Clinical Trials for People Living with Dementia (PLWD) and Their Care Partners.” Up to 25 participants will be accepted to attend the event on April 7 and 8, 2021. This ...

NIH Collaboratory researchers in 2020 reported study results, generated new knowledge, and developed innovative research methods in pragmatic clinical trials. Their work included insights from the Coordinating Center and Core Working Groups, analyses from the NIH Collaboratory Distributed Research Network, and results and methodological approaches from the NIH Collaboratory Trials. So far this year, the NIH ...

Longtime NIH Collaboratory researcher Dr. Vincent Mor will lead a study to identify adverse health impacts among elderly nursing home residents following COVID-19 vaccination. The study is supported by a supplemental award from the National Institute on Aging to the NIA IMPACT Collaboratory. It will be used to design an adverse event monitoring system in ...

The Patient-Centered Outcomes Research Institute (PCORI) will issue a funding announcement in January for pragmatic clinical studies to evaluate patient-centered outcomes. A total of $90 million will be available in the funding cycle to support individual awards of up to $10 million in direct costs with a maximum project duration of 5 years. More from the ...