Grand Rounds Series: Clinical Trials in the Time of COVID-19

During the COVID-19 pandemic, the NIH Pragmatic Trials Collaboratory held a special Grand Rounds series to share late-breaking research and promote resources in support of clinical researchers affected by the COVID-19 public health emergency. Sessions featured a variety of COVID-19−related topics, bringing together Core Working Group members, NIH Collaboratory Trial teams, and the broader research community to stay connected during the challenging and rapidly evolving time.

Access the recordings:

• January 6, 2023: Outpatient Treatment of COVID-19 With Metformin, Ivermectin, or Fluvoxamine: 10-Month Follow-up and Effects on Developing Long COVID (Carolyn Bramante, MD, MPH; Thomas Murray, PhD)
• October 28, 2022: "The HERO (Healthcare Worker Exposure Response & Outcomes) Program: An Online Community to Support Observational Studies, Randomized Trials, and Long-Term Safety Surveillance" (Emily O’Brien, PhD, FAHA; Russell Rothman, MD, MPP)
• July 29, 2022: "Effect of Early Treatment With Single-dose Pegylated Interferon Lambda Among Patients With COVID 19: Results From The TOGETHER Trial" (Edward Mills, PhD; Jeffrey S. Glenn, MD, PhD)
• July 22, 2022: "ACTIV-6 Reaches 1 Year, Will Share Results in COVID-19 Grand Rounds" (Susanna Naggie, MD, MHS)
• July 15, 2022: "Overview of Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Public-Private Partnership and Lessons Learned" (Stacey J. Adam, PhD)
• July 8, 2022: "Results From the COVID-OUT Trial, a Phase-3 Trial of Outpatient Treatment for COVID-19 Using Metformin, Ivermectin, and Fluvoxamine" (Carolyn Bramante, MD, MPH; Thomas Murray, PhD; Jared Huling, PhD)
• May 20, 2022: "Long-COVID Studies Within the RECOVER Platform" (Upinder Singh, MD)
• April 8, 2022: "COVID-19 Surveillance in PCORnet: Year 2 Update" (Jason Block, MD, MPH; Thomas W. Carton, PhD, MS)
• March 18, 2022: "Better Data on Ivermectin Is Finally Here: Results From the TOGETHER Trial" (Edward Mills, PhD; Craig Rayner, PharmD)
• March 4, 2022: "ACP COVID: A Trial to Evaluate an Advance Care Planning Video and Communication Skills Training Intervention for Older Adults During an Evolving Pandemic" (Angelo E. Volandes, MD, MPH; James A. Tulsky, MD; Sophia N. Zupanc, BA)
• January 14, 2022: "Searching for a Unicorn: Understanding Stakeholder Perspectives When Selecting Outcomes for Outpatient Trials" (Christopher John Lindsell, PhD)
• November 12, 2021: "Using Financial Incentives to Increase COVID-19 Vaccine Uptake" (Charlene Wong, MD, MSPH)
• October 15, 2021: "The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh" (Jason Abaluck, PhD)
• October 1, 2021: "COVID-OUT: From Computer Modeling to a Phase III Trial of Early Outpatient Treatment for SARS-CoV-2 Infection" (Carolyn Bramante, MD, MPH; Thomas Murray, PhD; Jared Huling, PhD)
• August 20, 2021: "Fluvoxamine for Early Treatment of COVID-19: The STOP COVID Clinical Trials" (Eric Lenze, MD)
• August 13, 2021: "Got Anything for This Cough? Outpatient Treatment Trials in the Time of COVID" (Davey Smith, MD)
• August 6, 2021: "The TOGETHER Early Treatment of COVID Trial: Building Platform Trial Infrastructure for Infectious Diseases" (Edward Mills, PhD)
• July 23, 2021: "Long Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical Care" (Diana Berrent, JD; Natalie Lambert, PhD; Nick Guthe)
• July 9, 2021: "COVID-19 Vaccine Efficacy Studies: Challenges and Successes" (Hana El Sahly, MD)
• May 21, 2021: "The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and Delivery" (Chris Butler, MD; Ben Saville, PhD)
• May 7, 2021: "Online Recruitment in the Era of COVID-19: Pitfalls and Progress" (Megan L. Ranney, MD, MPH)
• April 30, 2021: "ACTIV-6: A Direct-to-Participant Platform Trial of Repurposed Drugs for COVID-19 in Non-hospitalized Patients" (Susanna Naggie, MD, MHS; Elizabeth Shenkman, PhD)
• April 23, 2021: "COVID Clinical Trials: the Intermountain Healthcare Experience" (Samuel M. Brown, MD, MS)
• April 16, 2021: Minnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity (Paul E. Drawz, MD, MHS, MS; Tyler Winkelman, MD, MSc)
• April 9, 2021: "Taking Research to the Participant: Experiences With TREAT NOW, a No-Touch COVID-19 Trial" (Adit Ginde, MD, MPH)
• April 2, 2021: "Lessons From COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform Trial" (Derek C. Angus, MD, MPH)
• March 19, 2021: "HERO–Learning Together About Vaccines for SARS-CoV-2" (Emily C. O'Brien, PhD; Robert M. Califf, MD)
• March 12, 2021: "Lessons Learned From the Gates MRI Virtual COVID-19 Trial" (Mohamed Bassyouni, PharmD; Jintanat Ananworanich, MD, PhD)
• March 5, 2021: "Data and Safety Monitoring Boards for Trials of COVID-19 Treatments and Vaccines: The Challenges" (Susan S. Ellenberg, PhD)
• February 19, 2021: "Beyond Politics: Beyond Politics: Promoting COVID Vaccination in the US" (Kevin A. Schulman, MD)
• February 5, 2021: Generating High-Quality Evidence During a Pandemic: The Brazilian COALITION Experience (Renato Lopes, MD, MHS, PhD)
• January 29, 2021: "The COVID-19 Citizen Science Study" (Gregory M. Marcus, MD, MAS)
• January 15, 2021: "How CTTI and the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic" (Pamela Tenaerts, MD, MBA)
• January 8, 2021: "HERO-Together: Building Vaccine Confidence With Long-Term Outcomes Data" (Emily C. O'Brien, PhD)
• December 11, 2020: "PREVENTABLE: Starting a Pragmatic Trial in a Pandemic" (Karen P. Alexander, MD; W. Schuyler Jones, MD)
• October 30, 2020: "Lessons From Virtual Trials in the Time of a Pandemic: Minnesota Hydroxychloroquine Experience" (David R. Boulware, MD, MPH, CTropMed)
• October 16, 2020: "Back to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative" (Danny Benjamin, MD, PhD; Kanecia Zimmerman, MD, MPH)
• September 25, 2020: "Accelerating the Nation's COVID-19 Testing Capacity: An Update From the NIH's RADx Program" (Rick Bright, PhD; Rachael Fleurence, PhD)
• September 11, 2020: "Launching CONNECTS: Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies" (Gordon R. Bernard, MD; Sonia Thomas, DrPH)
• August 21, 2020: "Adaptive Platform Trials: Scalable From Breast Cancer to COVID" (Laura Esserman, MD, MBA)
• July 10, 2020: "COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C)" (Ken Gersing, MD; Robert A. Star, MD)
• June 5, 2020: "PCORnet COVID-19 Common Data Model Design and Results" (Thomas Carton, PhD, MS; Keith Marsolo, PhD; Jason Perry Block, MD, MPH)
• May 15, 2020: "Optimizing Learning While Doing: The REMAP-CAP Adaptive Platform Trial" (Derek C. Angus, MD, MPH, FRCP)
• May 1, 2020: “Can the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem?" Keynote address for EHR Workshop Grand Rounds Series: “Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials” (Robert M. Califf, MD, MACC)
• April 24, 2020: “The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised With COVID-19” (Martin Landray, PhD, FRCP)
• April 17, 2020: “The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence” (Nakela Cook, MD, MPH; Josie Briggs, MD; Susanna Naggie, MD; Emily O’Brien, PhD; Russell Rothman, MD; Chris Forrest, MD, PhD)
• April 10, 2020: “Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial” (Sean Collins, MD, MSc)
• April 3, 2020: “Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research” (Harlan Krumholz, MD; Bala Hota, MD, MPH; Graham Nichol, MD, MPH)
• March 20, 2020: "Clinical Trials in the Time of COVID-19" (Susanna Naggie, MD; Adrian Hernandez, MD, MHS; Eric Perakslis, PhD)