Speakers
Karen P. Alexander, MD
Professor of Medicine/Cardiology
Duke University School of Medicine
W. Schuyler Jones, MD
Associate Professor of Medicine/Cardiology
Duke University School of Medicine
Topic
PREVENTABLE: Starting a Pragmatic Trial in a Pandemic
Keywords
Heart disease; Dementia; Cholesterol; Statins; Pragmatic trial; National Heart, Lung, and Blood Institute; National Institute on Aging; Mild cognitive impairment
Key Points
- More than half of older adults (age 75+) in the United States have cognitive impairment or frailty or both.
- PREVENTABLE is one of the largest research studies in older adults. The purpose is to learn if taking a statin could help older adults live well for longer by preventing dementia, functional decline, or heart disease.
- The study medication (statin) is mailed directly to participants’ homes. Study sites are part of the research infrastructure within PCORnet and Veterans Affairs (VA).
- Pragmatic aspects of the trial include the study question: Do statins work in practice for outcomes that matter most to older adults? Also, enrollment is telehealth-enabled, and consent is electronic (e-Consent).
Discussion Themes
How did the study team work with IT to make the EHR system changes (eg, tools and workflow) needed to conduct the research?
Are older participants able to interact well with the technology used in the trial?
Are there special considerations embedded within the study to encourage the retention of study participants?
Read more about the PREVENTABLE study.
Tags
#pctGR, @Collaboratory1