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NIH Collaboratory
Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures

Additional Resources

CHAPTER SECTIONS

Participant Recruitment


Section 7


Additional Resources

Expand Contributors

Adeola Jaiyeola, MD, MHSc
Barbara L. Wells, PhD

Contributing Editor
Liz Wing, MA

Journal articles
Role of health plan administrative claims data in participant recruitment for pragmatic clinical trials: An Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE) example (Shi et al. 2020) Using administrative claims data to identify potential trial participants and facilitate recruitment and enrollment for PCTs
Series: Pragmatic Trials and Real World Evidence: Paper 3. Patient Selection Challenges and Consequences (Oude Rengerink et al. 2017) Recruitment challenges within a routine care setting
Recruiting community health centers into pragmatic research: Findings from STOP CRC (Coronado et al. 2015) Recruitment challenges within community settings
PCT Grand Rounds webinars
July 31, 2020 Using Real-World Data to Plan Eligibility Criteria and Enhance Recruitment: Actionable Recommendations and Resources from the Clinical Trials Transformation Initiative
September 13, 2019 ADAPTABLE Recruitment and Follow-up: Health Plan Research Network Engagement
August 23, 2019 Oh Yes, We Have Tons of Patients Who Can Do This Study!
July 26, 2019 Digital in Trials: Improving Participation and Enabling Novel Endpoints
May 17, 2019 The Vitamin D and Omega-3 Trial (VITAL): Design and Results of a Large Pragmatic Trial
May 4, 2018 Leveraging Community Engagement and Informatics-Based Tools to Increase Participant Recruitment and Retention
March 3, 2017 Showcasing Innovative Operational and Recruitment Approaches in the ADAPTABLE Trial
Other recruitment resources
Trial Innovation Network The Trial Innovation Network is a collaborative initiative supported by the National Center for Advancing Translational Sciences (NCATS) at the NIH. One of the network’s resources is a Recruitment Innovation Center (RIC) that assists with evidenced-based recruitment and retention methods, tools, and strategies.
ADAPTABLE PCORnet's Aspirin study website with detailed trial information, including protocol, consent form, and videos
Diuretic Comparison Project Veterans Affairs (VA) project website with details about the study
CTTI Recommendations (PDF) Clinical Trials Transformation Initiative (CTTI) resources for efficient and effective trial recruitment

Previous Section

DISCLAIMER: The views expressed in this chapter are those of the contributors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.

SECTIONS

CHAPTER SECTIONS

sections

  1. Introduction
  2. Questions to Consider
  3. Case Study: ICD-Pieces™
  4. Payments and Incentives
  5. Recruitment Highlights
  6. Clinician Recruitment Case Study: HERO
  7. Additional Resources

REFERENCES

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Version History

August 25, 2020: Added resources to the table including hyperlinks. Removed References section at bottom of page (changes made by L. Wing).

December 18, 2018: Made nonsubstantive edits as part of annual content update (changes made by L. Wing).

December 5, 2018: Added link to 5/4/2018 Grand Rounds in resource box as part of annual content update (changes made by L. Wing).

Published August 25, 2017

current section :

Additional Resources

  1. Introduction
  2. Questions to Consider
  3. Case Study: ICD-Pieces™
  4. Payments and Incentives
  5. Recruitment Highlights
  6. Clinician Recruitment Case Study: HERO
  7. Additional Resources

Citation:

Jaiyeola A, Wells BL. Participant Recruitment: Additional Resources. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Pragmatic Trials Collaboratory. Available at: https://rethinkingclinicaltrials.org/chapters/conduct/recruitment/recruitment-resources/. Updated December 3, 2025. DOI: 10.28929/067.

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