When planning a trial's recruitment activities, it would be helpful for study teams to consider important questions like the following:

• Who (individuals or groups) will be the targets of the embedded intervention?
• What recruitment methods will be needed in the context of the trial’s randomization scheme, inclusion criteria, enrollment goals, and clinical workflow?
• What recruitment materials and procedures will be developed?
• How will eligible participants be contacted and enrolled, whether individual participants or clusters of clinics or clinicians?
• How will the partner health system’s EHR be used for study recruitment, enrollment, intervention delivery, and/or outcome assessment?
• What barriers to recruitment are anticipated, and how will these challenges be addressed?

The next section elaborates on each of these recruitment considerations as illustrated by a real-life ePCT case study from the NIH Collaboratory Trials.

DISCLAIMER: The views expressed in this chapter are those of the contributors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.