2026

Podcast October 27, 2026: Piloting and Assessing Feasibility (Sebastian Tong, MD; Gregory Simon, MD)

Posted on by Sophia Ramirez

Sebastian Tong of the University of Washington and Gregory Simon of the Kaiser Permanente Washington Health Research Institute discuss piloting and assessing feasibility in pragmatic trials. This is the second episode in the NIH Collaboratory’s 4-part educational podcast series, “Laying the Foundation for Successful Pragmatic Trials.”

Access resources related to this episode. Transcript coming soon. For alerts about new episodes, subscribe for free on Spotify, Amazon Music, Apple Podcasts, or SoundCloud.

Podcast September 22, 2026: Designing Fit-for-Purpose ePCTs (Wendy Weber, ND, PhD, MPH; Adrian Hernandez, MD, MHS)

Posted on by Sophia Ramirez

National Center for Complementary and Integrative Health (NCCIH) Director Wendy Weber and NIH Collaboratory co-PI Adrian Hernandez discuss fit-for-purpose trials and what researchers need to consider during the design phase. This discussion sets the stage for the NIH Collaboratory’s new 4-part educational podcast series, “Laying the Foundation for Successful Pragmatic Trials.”

Access resources related to this episode. Transcript coming soon. For alerts about new episodes, subscribe for free on Spotify, Amazon Music, Apple Podcasts, or SoundCloud.

Endpoint Strategy in Pragmatic Trials: NIH Collaboratory Virtual Workshop (September 2026)

Posted on by Sophia Ramirez

September 8-9, 2026: This 2-day workshop explored the factors involved in selecting endpoints and interpreting treatment effects in embedded pragmatic clinical trials (ePCTs) to best inform decision-making. A series of panels addressed considerations for selecting endpoints that reliably measure concepts of interest in ePCTs; influential factors in the analysis and interpretation of treatment effects; applications of multicomponent and hierarchical endpoints; and real-world examples of various endpoint strategies in ePCTs.

Agenda

Workshop Description

Workshop Summary

Workshop Recording

Agenda, Slides, and Recordings

Day 1: September 8

Welcome and Introduction

Wendy Weber, ND, PhD, MPH
David Shurtleff, PhD
Kevin Weinfurt, PhD

Opening Presentation: Defining the Endpoint: Where Evidence Begins

Kevin Weinfurt, PhD

▶️ Watch the recording

Session 1: Aiming for Impact: What is the Right Concept to Target?

Moderator: Steven George, PT, PhD, FAPTA

Panel:

  • Michael Ho, MD, PhD
  • Frederick Masoudi, MD, MSPH, MACC, FAHA
  • Miguel Vazquez, MD
  • Tracy Wang, MD, MHS, MSc
  • Wendy Weber, ND, PhD, MPH

▶️ Watch the recording

Session 2: The Estimands Framework: Aligning Objectives, Endpoints, and Analyses

Moderator: Liz Turner, PhD

Panel:

  • Elizabeth Colantuoni, PhD, ScM
  • Fan Li, PhD
  • Richard Skolasky, Jr, MA, ScD
  • Hulin Wu, PhD

▶️ Watch the recording

Session 3: Working With Multiple Outcomes: Multicomponent Endpoints and Beyond

Moderator: Emily O’Brien, PhD

Panel:

  • Julie Fritz, PhD, PT
  • Patrick Heagerty, PhD
  • Eric Roseen, DC, PhD
  • Pamela Shaw, PhD, MS
  • Qilu Yu, PhD

▶️ Watch the recording

Summary and Concluding Remarks

Steven George, PT, PhD, FAPTA
Emily O’Brien, PhD
Liz Turner, PhD
Kevin Weinfurt, PhD

Day 2: September 9

Welcome and Introduction

Wendy Weber, ND, PhD, MPH
David Shurtleff, PhD
Kevin Weinfurt, PhD

Opening Presentation: Moving From Measurement to Meaning

Kevin Weinfurt, PhD

▶️ Watch the Recording

Session 4: Unpacking Uncertainty, Meaningfulness, and Magnitude

Moderator: Greg Simon, MD, MPH

Panel:

  • Devon Check, PhD
  • Lynn DeBar, PhD, MPH
  • Juan Marcos Gonzalez, PhD
  • Laura Lee Johnson, PhD
  • Natalia Morone, MD, MS

▶️ Watch the Recording

Session 5: Toward Best Practices for Interpretation of Endpoints

Moderators: Adrian Hernandez, MD, MHS; Kevin Weinfurt, PhD

Panel:

  • Andrea Cook, PhD
  • Corita Grudzen, MD, MSHS
  • Liz Turner, PhD
  • Kari Stephens, PhD
  • Christy Zigler, PhD, MSEd

▶️ Watch the Recording

Summary and Concluding Remarks

Patrick Heagerty, PhD
Adrian Hernandez, MD, MHS
Greg Simon, MD, MPH
Kevin Weinfurt, PhD

Podcast August 14, 2026: Bringing Context and Clarity to Clinical Trial Research with JAMA+ Trials (Alison Huang, MD, MAS; Derek Angus, MD, MPH)

Posted on by Sophia Ramirez

In this episode of the NIH Collaboratory Podcast, Alison Huang and Derek Angus of JAMA+ Trials expand on key takeaways from their recent Grand Rounds presentation, “Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences.”

Transcript coming soon. For alerts about new episodes, subscribe for free on Spotify, Amazon Music, Apple Podcasts, or SoundCloud.

Podcast July 15, 2026: Slow Recruitment Mitigation Strategies (Christine Goertz, PhD; Steven George, PhD)

Posted on by Sophia Ramirez

In this episode of the NIH Collaboratory Podcast, Steven George and Christine Goertz discuss slow recruitment mitigation strategies, one of the small group discussion topics at the NIH Pragmatic Trial Collaboratory’s Steering Committee meeting in April 2026.

Transcript coming soon. For alerts about new episodes, subscribe for free on Spotify, Amazon Music, Apple Podcasts, or SoundCloud.

Podcast June 22, 2026: Death as an Endpoint (Brad Hammill, PhD; Keith Marsolo, PhD)

Posted on by Sophia Ramirez

In this episode of the NIH Collaboratory Podcast, Brad Hammill and Keith Marsolo discuss the use of death as an endpoint, a section in the Living Textbook chapter on Choosing and Specifying Endpoints and Outcomes.

Transcript coming soon. For alerts about new episodes, subscribe for free on Spotify, Amazon Music, Apple Podcasts, or SoundCloud.

Innovations in Embedded Pragmatic Clinical Trials: Society for Clinical Trials (May 2026)

Posted on by Sophia Ramirez

May 17, 2026: The NIH Pragmatic Trials Collaboratory hosted a preconference workshop, "Innovations in Embedded Pragmatic Clinical Trials,” at the 47th Annual Meeting of the Society for Clinical Trials in Phoenix. This training workshop introduces opportunities for embedded research along with strategies for conducting innovative ePCTs that provide real-world evidence necessary to inform improvements in healthcare.

Agenda
Speaker Biographies
Program Overview
Participant Guide

Agenda and Slides

Welcome
Emily O'Brien, PhD

Session 1: Opportunities for Embedded Pragmatic Clinical Trials (ePCTs)
Wendy Weber, ND, PhD, MPH

Session 2: Engaging and Aligning With Partners
Emily O'Brien, PhD

Session 3: ePCT Design
Patrick Heagerty, PhD

Session 4: Innovative Methods in ePCTs
Angelo Volandes, MD, MPH

 

Session 5: Overview of NIH Collaboratory Trials
*This presentation contains case studies

Session 6: ePCTs in Context: Small Group Work and Panel Discussion With NIH Collaboratory Trial PIs
Moderators: Emily O'Brien, PhD; Nana Martinson, MPH
Panel: Sebastian Tong, MD, MPH; Michael Ho, MD, PhD

Closing Remarks
Emily O'Brien, PhD; Wendy Weber, ND, PhD, MPH

 

 

Case Studies

Examples from NIH Collaboratory Trials: