July 25, 2018: NIH Collaboratory Launches 5 New Demonstration Projects

This post was updated on August 20, 2018.

The NIH Collaboratory is excited to announce the addition of 5 new large-scale pragmatic clinical trials to its portfolio of innovative Demonstration Projects. The new research awards, which are supported by 6 NIH institutes, centers, and offices, total $4.15 million for an initial 1-year planning phase and an estimated $30.85 million for 4 years of study implementation.

NIH Collaboratory Demonstration Projects are multicenter, pragmatic trials that engage healthcare delivery systems in research partnerships to gather real-world evidence and answer clinical questions of major public health importance. Five Core Working Groups of experts, each focused on a specific topic related to the implementation of pragmatic clinical trials, support all of the Demonstration Projects. The Core Working Groups help the research teams address challenges of conducting research embedded in clinical care, and they collect and disseminate knowledge and best practices learned throughout the process.

In its first 5 years, the NIH Collaboratory successfully guided 10 complex Demonstration Projects through the planning phase, 9 of which proceeded to full study implementation.

The 5 new Demonstration Projects are supported by the National Center for Complementary and Integrative Health (NCCIH), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Aging (NIA), the National Institute on Drug Abuse (NIDA), the Office of Behavioral and Social Sciences Research (OBSSR), and the Office of Disease Prevention (ODP). They include:

Over the next 5 years, the new Demonstration Projects will extend the NIH Collaboratory’s mission to improve how clinical trials are conducted by creating a new infrastructure for implementing cost-effective, large-scale research studies that involve healthcare delivery organizations.

Update: The NIH Collaboratory subsequently announced a sixth new Demonstration Project, HiLo. Watch a video interview about the new projects with NIH Collaboratory leaders.