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NIH Collaboratory
Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures

tools

Introduction to ePCTs: Self-Paced Study

Posted on January 17, 2019October 19, 2021 by Gina Uhlenbrauck

Introduction to ePCTs: Self-Paced Study

Ten self-paced learning modules on how to design, conduct, and disseminate ePCTs

Posted in tools, training Tagged pdf

NIH Collaboratory Program Overview Presentation – Training Resources Page

Posted on September 4, 2018December 3, 2025 by Gina Uhlenbrauck

NIH Collaboratory Program Overview 

A presentation of the NIH Collaboratory’s goals and organizational structure along with a brief introduction to each NIH Collaboratory Trial.

Posted in tools, training Tagged pdf, [link type as list in grid above]

ePCT Factsheet – Training Resources Page

Posted on September 4, 2018December 6, 2022 by Gina Uhlenbrauck

ePCT Factsheet 

An infographic introducing the elements of the NIH Collaboratory program and the value of engaging in pragmatic research

Posted in tools, training Tagged pdf, [link type as list in grid above]

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