UH3 Project: Strategies and Opportunities to Stop Colorectal Cancer in Priority Populations (STOP CRC)

UH3 Project: Strategies and Opportunities to Stop Colorectal Cancer in Priority Populations (STOP CRC)

Principal Investigator: Gloria D. Coronado, PhD

Co-Principal Investigator: Beverly B. Green, MD, MPH

Sponsoring Institution: Kaiser Permanente Center for Health Research


  • Federally qualified health centers in the Oregon Community Health Information Network (OCHIN)

  • Kaiser Permanente Washington Health Research Institute

  • The National Center for Complementary and Integrative Health (NCCIH)

NIH Institute Providing Oversight: National Cancer Institute (NCI)

Program Official: Erica Breslau (NCI)

Project Scientist: Jerry Suls (NCI)

ClinicalTrials.gov Identifier: NCT01742065

Study Locations: Affiliated clinics in California and Oregon 

Trial Status: Completed

Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. Yet CRC is 90% curable with timely detection and appropriate treatment of precancerous polyps; increased screening could reduce incidence by up to 50%. Rates of CRC screening are extremely low in patients at federally qualified health centers (FQHCs), which serve nearly 19 million patients annually. To address this disparity, the STOP CRC trial tests a culturally tailored, health care system–based program to improve CRC screening rates in OCHIN, a community-based collaborative network of more than 200 FQHCs. Results will provide information on how to use electronic health record resources to optimize guideline-based screening in FQHC clinics whose patient populations have disproportionately low CRC screening rates.

NIH Project Information


5/14/2018: STOP CRC: Demonstration Project Presentation at Steering Committee Meeting (PDF)

2/23/2018: Grand Rounds Presentation: Direct Mail Programs Work ... But Will Health Centers Implement Them? Findings from STOP CRC

5/23/2017: STOP CRC: Top Barriers/Challenges and Recent Generalizable Lessons Learned (PDF)

11/4/16: Grand Rounds Presentation: Colorectal Cancer Screening in Primary Care: A Focus on STOP CRC (Video; Slides)

5/9/2016: STOP CRC: Data Governance and Data Sharing Presentation at Steering Committee Meeting (PDF)

5/9/2016: STOP CRC: Generalizable Lessons Learned Presentation at Steering Committee Meeting (PDF)

4/24/2015: Grand Rounds Presentation: Analytic Challenges from the STOP CRC Trial: Pragmatic Solutions for Pragmatic Problems (Video; Slides)

4/21/2015: Update on Demonstration Project at Steering Committee Meeting (PDF)

11/7/2014: Grand Rounds Presentation: Early Findings from Strategies and Opportunities to STOP Colon Cancer in Priority Populations (Video; Slides)

9/26/2014: Grand Rounds Presentation: Clinical Decision Support to Improve Colorectal Cancer Screening (Video; Slides)

4/26/2014: Grand Rounds Presentation: STOP CRC in the Context of an Ethical Framework for Learning Health Systems (Video;Slides)

2/24/2014: Demonstration Project Presentation at Steering Committee Meeting (PDF)

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Demonstration Projects: UH3 Project: Strategies and Opportunities to Stop Colorectal Cancer in Priority Populations (STOP CRC). In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Health Care Systems Research Collaboratory. Available at: https://rethinkingclinicaltrials.org/demonstration-projects/uh3-project-strategies-and-opportunities-to-stop-colorectal-cancer-in-priority-populations-stop-crc/. Updated November 7, 2019.