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NIH Collaboratory
Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures

Additional Resources

CHAPTER SECTIONS

Developing a Compelling Grant Application


Section 8

Additional Resources

Expand Contributors

Marcel Salive, MD, MPH
Wendy J. Weber, ND, PhD, MPH

Contributing Editor
Karen Staman, MS

NIH Application Guide Provides guidance on preparing to apply and on writing and submitting applications for clinical trials to NIH.
Simplified Review Framework for NIH Research Project Grant Applications Describes a new framework to better focus peer reviewers on the key questions needed to assess the scientific and technical merit of proposed research projects.
New Review Criteria for Research Project Applications Involving Clinical Trials Describes NIH review criteria for clinical trial applications.
Research Methods Resources Website Provides resources for investigators considering group- or cluster-randomized designs, including lists of NIH webinars, key references, and statements to help investigators prepare sound applications and avoid methodological pitfalls.
PCORI’s Research Funding Process Details each step of the PCORI funding process.
Value of Engagement in Research Defines engagement in research and introduces PCORI’s Foundational Expectations for Partnerships in Research.

Previous Section

SECTIONS

CHAPTER SECTIONS

sections

  1. Introduction
  2. Find the Right Program Official and Study Section
  3. Find the Notice of Funding Opportunity
  4. Write a Strong Proposal That Addresses Review Criteria
  5. Special Considerations
  6. Award Status
  7. Review Criteria
  8. Additional Resources

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DISCLAIMER

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The views expressed in this chapter should not be interpreted as representing the official views of the US Department of Health and Human Services, the National Institutes of Health, the National Institute on Aging, the National Center for Complementary and Integrative Health or PCORI, except where noted.

ACKNOWLEDGEMENT

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The authors thank Dr. Tracy Wang, the chief officer for Comparative Clinical Effectiveness Research (CER) at the Patient-Centered Outcomes Research Institute (PCORI), for her review of the content related to PCORI.


Version History

October 18, 2024: Added information about PCORI as a funder (changes made by K. Staman).

March 29, 2024: Added resource (changes made by K. Staman).

July 2, 2020: Minor corrections to layout and formatting (changes made by D. Seils).

Published December 13, 2018

current section :

Additional Resources

  1. Introduction
  2. Find the Right Program Official and Study Section
  3. Find the Notice of Funding Opportunity
  4. Write a Strong Proposal That Addresses Review Criteria
  5. Special Considerations
  6. Award Status
  7. Review Criteria
  8. Additional Resources

Citation:

Salive M, Weber W. Developing a Compelling Grant Application: Additional Resources. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Pragmatic Trials Collaboratory. Available at: https://rethinkingclinicaltrials.org/chapters/design/developing-a-compelling-grant-application/additional-resources/. Updated December 3, 2025. DOI: 10.28929/119.

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