Videos

Videos

The NIH Pragmatic Trials Collaboratory has a large collection of training videos that cover topics related to every phase of an embedded pragmatic clinical trial (ePCT). Use our video library to learn about the many aspects of ePCTs. You can filter the videos by Topics, as they relate to content areas of the Living Textbook, or by Categories. Click the Reset Filters button to view the full library again. We also created a series of short, self-paced Learning Modules that you can view sequentially or individually. To find our Learning Modules, select the "Modules" option under the Topics filter.

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DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

The Big Picture: Healthcare Data and Interoperability

Presenter: Lesley Curtis, PhD
Date: 5/7/2025
Run Time: 10:00
In this video, Dr. Lesley Curtis explores how data flow into EHRs and move between systems, the role of data standards, and the barriers to building a more streamlined and connected healthcare system.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Common Data Models

Presenter: Lesley Curtis, PhD
Date: 5/7/2025
Run Time: 12:50
In this video, Dr. Lesley Curtis explores Common Data Models (CDMS). Topics include: How CDMs work, customizing CDMs for specific research questions, challenges and benefits of CDMs, and the future of CDMs.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

How Do You Design Trials That Are Fit for Purpose?

Presenter: Lesley Curtis, PhD
Date: October 20, 2023
Run Time: 7:07
Dr. Lesley Curtis discusses how to design pragmatic trials that are fit for purpose by using the PRECIS-2 tool, which underscores the many considerations that go into the underlying pragmatism of a trial.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Including All Populations in Pragmatic Clinical Trials

Presenter: Rosa Gonzalez-Guarda, PhD, MPH, RN, FAAN; Rachel Gold, PhD, MPH; Karen Kehl, PhD, RN, FPCN
Date: April 20, 2022
Run Time: 12:21
Learn about challenges and solutions for investigators as they strive to include all populations in research.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

The Stepped Wedge Cluster Randomized Trial: Friend or Foe?

Presenter: Monica Taljaard, PhD; David Magnus, PhD
Date: December 9, 2022
Run Time: 59:51
Dr. Monica Taljaard and Dr. David Magnus present their lessons learned from using stepped-wedge designs in ePCTs.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Is a PCT Right for Your Research Question?

Presenter: Wendy Weber, ND, PhD, MPH
Date: October 20, 2023
Run Time: 2:18
The first step to determining if a pragmatic clinical trial is right for your research question is identifying what you want your research study to answer, says Dr. Wendy Weber.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Swimming with the Sharks: Translation of Pragmatic Trial Results

Presenter: Gregory Simon, MD, MPH
Date: May 24, 2017
Run Time: 40:25
To illustrate the importance of health system leader engagement, Dr. Greg Simon is tasked with convincing healthcare system leadership to invest in implementing the intervention from the Suicide Prevention Outreach Trial (SPOT).
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Why Should I Do A Pragmatic Trial?

Presenter: Lesley Curtis, PhD
Date: October 20, 2023
Run Time: 1:58
There are typically two reasons to do a pragmatic clinical trial. The first is to generate real-world evidence that will inform how to deliver care. The second reason is to generate evidence faster and for less money than a traditional trial.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Real-World Data and Real-World Evidence in Regulatory Decisions

Presenter: Jaqueline Corrigan-Curay, JD, MD
Date: May 8, 2020
Run Time: 21:17
Dr. Jacqueline Corrigan-Curay of the US Food and Drug Administration discusses recent trends in incorporating real-world data and real-world evidence in regulatory decisions.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are Pragmatic Clinical Trials?

Presenter: Lesley Curtis, PhD
Date: October 20, 2023
Run Time: 1:36
Dr. Lesley Curtis describes the characteristics of a pragmatic clinical trial, which typically are large, efficient studies done in the real world that result in evidence for the adoption of an intervention into clinical practice.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are Some Success Strategies for Writing PCT Grant Applications?

Presenter: Wendy Weber, ND, PhD, MPH
Date: October 20, 2023
Run Time: 2:02
It's important to be thorough, informed, timely, and clear when discussing the research question for a PCT grant application.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are the Reasons to Randomize Clusters Instead of Individuals?

Presenter: Liz Turner, PhD
Date: October 20, 2023
Run Time: 0:54
Dr. Liz Turner discusses reasons to randomize clusters instead of individuals, making it logistically easier to implement the intervention your trial is studying.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Assessing Data Quality

Presenter: Rachel Richesson, PhD
Date: July 17, 2020
Run Time: 8:42
This video describes steps for assessing data quality, including identifying variation between populations at different sites and assessments of accuracy, completeness, and consistency.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are the Types of CRT Designs?

Presenter: Liz Turner, PhD
Date: October 20, 2023
Run Time: 2:47
Dr. Liz Turner discusses the features of two types of cluster randomized trials, regular parallel arm and the stepped-wedge design.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Ethical Considerations When Vulnerable Populations are Subjects in Pragmatic Trials

Presenter: Emily A. Largent, JD, PhD, RN
Date: January 13, 2023
Run Time: 58:14
Dr. Emily Largent explains that while it is ethically acceptable and imperative to enroll vulnerable subjects in research, we must also think about their vulnerability in systematic ways.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are the Key Factors in Using EHR Data for Endpoints and Outcomes?

Presenter: Rachel Richesson, PhD
Date: October 20, 2023
Run Time: 1:12
Dr. Rachel Richesson discusses the key factors in using EHR data for endpoints and outcomes, emphasizing EHR data should be easy to collect, explicit, reproducible, and useful.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Reaching Rural Populations: BeatPain Utah

Presenter: Julie Fritz, PhD, PT; David Wetter, PhD
Date: June 4, 2021
Run Time: 16:31
In this video, the BeatPain Utah team shares their strategies for reaching and enrolling rural and frontier populations. Key characteristics of good partnerships are shared goals, mutual respect of expertise, and shared resources and data.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

EHR-Based Outcome Measurement in the LIRE Trial

Presenter: Jerry Jarvik, MD, MPH
Date: June 4, 2021
Run Time: 10:13
In this video, Dr. Jerry Jarvik, PI of the LIRE trial, summarizes the challenges his team faced when embedding a radiology reporting intervention into the electronic health record.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Using Clinical Data to Advance Discovery

Presenter: Josh Denny, MD, MS
Date: May 8, 2020
Run Time: 17:10
In this video, Dr. Josh Denny of the NIH's All of Us Research Program describes how researchers are building powerful algorithms for use across electronic health records systems to advance clinical research.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Community-Based Participatory Research Practices in the GRACE Trial

Presenter: Judith Schlaeger, PhD, CNM, LAc, FACNM, FAAN
Date: June 25, 2021
Run Time: 11:34
Dr. Judith Schlaeger of the University of Illinois Chicago discusses the use of community-based participatory research practices in the GRACE trial, an NIH Collaboratory Demonstration Project.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Do Endpoints and Outcomes Look Like in Pragmatic Trials?

Presenter: Devon Check, PhD
Date: October 20, 2023
Run Time: 2:24
Endpoints and outcomes are different in pragmatic trials than in explanatory trials. In pragmatic trials, outcomes and endpoints should be meaningful to key stakeholders, easy to collect, and relying on routinely collected data.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

How Do Data Sources inform the Choice of Endpoints and Outcomes in Pragmatic Trials?

Presenter: Devon Check, PhD
Date: October 20, 2023
Run Time: 2:36
Pragmatic clinical trials are often dealing with multiple sources of data from more than one health system, EHRs, and multiple payers claims databases. It can be a balancing act in terms of measurement and pragmatism.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Ethical Considerations for Data Sharing in Pragmatic Trials

Presenter: Stephanie Morain, PhD, MPH
Date: May 11, 2022
Run Time: 3:41
Dr. Stephanie Morain discusses a supplemental grant award to study the ethical issues that arise in data sharing in the context of pragmatic trials.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Ensuring Participant Representativeness: STOP CRC

Presenter: Amanda Petrik, PhD, and Gloria Coronado, PhD
Date: June 4, 2021
Run Time: 16:19
The STOP CRC trial investigators deployed many strategies to ensure the inclusion of all populations in their trial, including piloting the trial, refining the materials based on patient feedback, assembling an advisory board, and conducting plan-do-study-act cycles at the sites.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are the Challenges of Using Data Directly From the EHRs?

Presenter: Rachel Richesson, PhD
Date: October 20, 2023
Run Time: 1:23
Dr. Rachel Richesson discusses the challenges of using data directly from the electronic health records (EHRs), including differences in systems different data coding and representation conventions. 
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are the Arguments For and Against the Stepped-Wedge Design?

Presenter: Liz Turner, PhD
Date: October 20, 2023
Run Time: 1:34
Dr. Liz Turner discusses arguments for and against using the stepped-wedge design when choosing the right cluster randomized trial in pragmatic research.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Pilot and Feasibility Testing: The LIRE Example

Presenter: Jerry Jarvik, MD, MPH
Date: February 28, 2020
Run Time: 18:09
Pilot testing improves the likelihood of a successful trial and is an opportunity to maximize acceptability, maintain affordability, and consider scalability.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Is the Intraclass Correlation Coefficient?

Presenter: Liz Turner, PhD
Date: October 20, 2023
Run Time: 1:36
Dr. Liz Turner discusses the Intraclass Correlation Coefficient (ICC), which is the measure between cluster outcome variability relative to the overall variability in the system.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Engaging With Stakeholders in Pragmatic Clinical Trials

Presenter: Gregory Simon, MD, MPH
Date: January 31, 2020
Run Time: 10:35
In this video, Dr. Greg Simon shares how to engage with a range of stakeholders, both early and throughout the process of pragmatic clinical trials.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Is A Computable Phenotype?

Presenter: Rachel Richesson, PhD
Date: October 20, 2023
Run Time: 1:12
Dr. Rachel Richesson discusses the specifications of defining computable phenotypes.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Is An Example of How to Choose a Study Design?

Presenter: Liz Turner, PhD
Date: October 20, 2023
Run Time: 5:28
Dr. Liz Turner provides a framework for choosing a study design by discussing the design of SPOT, STOP CRC, LIRE, and OPTIMUM, which are all Demonstration Projects within the Collaboratory.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Uses of EHRs in NIH Collaboratory Projects

Presenter: Rachel Richesson, PhD
Date: June 26, 2020
Run Time: 18:52
In the NIH Pragmatic Trials Collaboratory ePCTs, the electronic health record has been used to determine eligibility, deliver the intervention, and assess outcomes. This video explores challenges and lessons learned encountered by the ICD-Pieces Trial.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Informing and Consenting: What Are the Goals?

Presenter: Pearl O’Rourke, MD; David S. Wendler, PhD, MA; Miguel Vazquez, MD; Michael Ho, MD, PhD
Date: February 10, 2023
Run Time: 1:00:13
Learn about the difference between informing participants about research and the informed consent process.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are Endpoints and Outcomes?

Presenter: Devon Check, PhD
Date: October 20, 2023
Run Time: 00:42
Dr. Devon Check discusses the difference between endpoints and outcomes in pragmatic clinical trials with endpoints referring to change in a measured variable and outcome describing the variable itself.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Is Outcome Clustering, and How Can It Affect a Trial?

Presenter: Liz Turner, PhD
Date: October 20, 2023
Run Time: 4:32
Dr. Liz Turner demystifies the notions of outcome clustering, which for a pragmatic trial might mean clustering at the level of a clinic and an intervention.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Collecting and Sharing Patient-Reported Outcomes in the PPACT Trial

Presenter: Lynn DeBar, PhD, MPH
Date: June 4, 2021
Run Time: 14:13
In this video, Dr. Lynn DeBar, PI of the PPACT trial describes how her team used electronic health records to collect and share patient-reported outcomes.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are Common Pitfalls in Writing PCT Grant Applications?

Presenter: Wendy Weber, ND, PhD, MPH
Date: October 20, 2023
Run Time: 2:29
Dr. Wendy Weber discusses common concerns expressed during the peer review process for writing PCT grant application and provides application recommendations from a reviewer's perspective. 
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

How Do You Estimate the Degree of Clustering for Outcomes?

Presenter: Liz Turner, PhD
Date: October 20, 2023
Run Time: 1:09
Dr. Liz Turner discusses estimating the degree of clustering for outcomes, starting with consulting other studies with similar settings and looking in the EHRs to see what data is available to inform and give a preliminary estimate of the ICC.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Designing With Implementation in Mind

Presenter: Leah Tuzzio, MPH; Vince Mor, PhD
Date: February 28, 2020
Run Time: 16:57
Key features discussed in the video include workflow, differences in potential delivery across different settings, and the value proposition for the healthcare system's leadership.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Data Infrastructure for Implementing the PROVEN Trial

Presenter: Vince Mor, PhD
Date: May 29, 2020
Run Time: 11:01
In this video, Dr. Vince Mor, Co-Principal investigator of the PROVEN trial, shares the data infrastructure that was essential to implementing and monitoring PROVEN.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Should I Avoid When Writing PCT Grant Applications?

Presenter: Wendy Weber, ND, PhD, MPH
Date: October 20, 2023
Run Time: 2:21
Dr. Wendy Weber provides an overview of elements to avoid when writing PCT grant applications from the perspective of an application reviewer.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Building a Study Team for a Pragmatic Clinical Trial

Presenter: Lesley Curtis, PhD
Date: January 31, 2020
Run Time: 6:11
Embedded pragmatic clinical trials require many different kinds of expertise, from the PI and Co-PI and biostatisticians to research assistants, communications specialists and more.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are the “Must Dos” of Writing PCT Grant Applications?

Presenter: Wendy Weber, ND, PhD, MPH
Date: October 20, 2023
Run Time: 4:31
Dr. Wendy Weber provides suggestions for writing PCT grant applications from the perspective of an application reviewer.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Pilot-Testing Interventions in Pragmatic Trials: SPOT Case Study

Presenter: Gregory Simon, MD, MPH
Date: February 21, 2018
Run Time: 9:03
Dr. Greg Simon summarizes pilot testing SPOT as a way of illustrating how pilot testing in ePCTs differs from more conventional randomized trials.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

How Does Clustering Affect Power and Detectable Difference?

Presenter: Liz Turner, PhD
Date: October 20, 2023
Run Time: 3:34
Dr. Liz Turner walks through an example that illustrates how clustering affects power and detectable difference.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

EHR Pragmatic Innovation Beyond Follow-up in the TSOS Study

Presenter: Doug Zatzick, MD
Date: May 29, 2020
Run Time: 4:50
Dr. Doug Zatzick of the University of Washington describes the unique challenges of using electronic health records in the TSOS study.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Finding the Right NIH Funding Opportunity

Presenter: Wendy Weber, ND, PhD, MPH
Date: March 27, 2020
Run Time: 13:07
Dr. Wendy Weber, the NIH Pragmatic Trials Collaboratory Program Official, shares insights about the 27 Institutes and Centers (ICs) across the National Institutes of Health.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

What Are the Benefits to Standardizing Phenotype Definition?

Presenter: Rachel Richesson, PhD
Date: October 20, 2023
Run Time: 1:08
Dr. Rachel Richesson discusses the benefits to standardizing phenotype definitions, which entails reusing and repurposing definitions for different studies.
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Is It Important to Explain the Definition of Pragmatic to Grant Reviewers?

Presenter: Wendy Weber, ND, PhD, MPH
Date: October 20, 2023
Run Time: 1:08
Dr. Wendy Weber discusses the importance of defining what it means to be pragmatic in the context of a specific study and whether or not each element of a study is pragmatic in a PCT grant application. 
DesignDisseminationData, Tools & ConductEthics and RegulatoryCommunity Health

Guiando Buenas Decisiones: Implementing GGC4H for Spanish-Speaking Families of Young Adolescents

Presenter: Stacy Sterling, DrPH, MSW
Date: June 25, 2021
Run Time: 15:35
Dr. Stacy Sterling of Kaiser Permanente Northern California discusses a pilot study to explore the feasibility of implementing a universal prevention curriculum for Spanish- speaking families of young adolescents, a supplement to GGC4H, an NIH Collaboratory Trial.