Quick Start Guide

Quick Start Guide

The NIH Collaboratory Quick Start Guide for Investigators is designed for clinical investigators interested in learning how to conduct an embedded pragmatic clinical trial (ePCT). It serves as an annotated table of contents, pointing readers to essential content in the Living Textbook needed to plan and launch an ePCT.

This guide will direct you to highlights of the Living Textbook, including chapters that will help you:

  • Learn what makes an ePCT different
  • Build partnerships to ensure a successful trial
  • Plan for sustainability from the beginning
  • Choose the right outcomes
  • Plan the study design and analysis
  • Consider oversight and monitoring
  • Test trial feasibility
  • Prepare to launch
  • Prepare for dissemination and implementation


Quick Start Guide: Quick Start Guide. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Health Care Systems Research Collaboratory. Available at: https://rethinkingclinicaltrials.org/quick-start-guide/. Updated March 26, 2020.