September 8, 2017: Leveraging Informatics in Pragmatic Research: Initial Experience in PCORnet


Russell Rothman, MD, MD, MPP, Professor, Internal Medicine, Pediatrics, & Health Policy
Vice President for Population Health Research
Director, Center for Health Services Research
Vanderbilt University Medical Center


Leveraging Informatics in Pragmatic Research: Initial Experience in PCORnet


Pragmatic clinical trial; Clinical research; Patient engagement; PCORI; PCORnet; Informatics; CDRN; Vanderbilt

Key Points

  • PCORnet includes Clinical Data Research Networks (CDRNs) for sharing informatics tools and engaging stakeholders.
  • The MidSouth CDRN, including Vanderbilt Medical Center and the Duke School of Medicine, comprises electronic health records of more than 9 million patients.
  • Novel informatics tools can quickly run queries, analyze health data, and collect survey data on patient-reported outcomes.
  • The ADAPTABLE study “disrupts the norm” from traditional trials with the PCORnetCommon Data Model and its patient-directed e-consent process.

Discussion Themes

Additional informatics tools available include expanded clinical decision support tools to help providers at the point of care, and expanded BioVu and Tissue repository for biologic studies

Regulatory efficiencies such as a central IRB and shared contracting templates should be utilized when possible

PCORnet can pull Medicare claims data to capture hospital or ED visit, as well as gather self-reported outcome data from patients directly, to gain a more complete picture

PCORnet has a wide variety of group participating in its network, both academic and non-academic, to ensure diversity in population recruitment

For More Information

For more information on PCORnet, visit; on the MidSouth CDRN, visit; on the BioVU, visit

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