On November 9, 2020, the NIH Collaboratory held a virtual onboarding meeting to welcome two new UG3 NIH Collaboratory Trials to its Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) program. More than 60 participants joined to welcome the new PRISM projects; provide introductions, an overview of the Collaboratory program and the NIH HEAL Initiative, hear from the new PRISM projects; and discuss lessons learned from other NIH Collaboratory Trials.