May 19, 2017: Trial Innovation Network and PCORnet: Collaborations and Synergies


Danny Benjamin, MD, PhD, Duke University, Chair of the Pediatric Trials Network and Associate Director of the Duke Clinical Research Institute

Adrian F. Hernandez, MD, MHS, Duke University Medical Center, and Director of Health Services and Outcomes Research and Faculty Associate Director of the Duke Clinical Research Institute

Monica Shah, MD, Director of the Trial Innovation Network, Division of Clinical Innovation, National Center for Advancing Translational Sciences at the National Institutes of Health

Gordon R. Bernard, MD, Executive Vice President for Research and Director of the Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center


Trial Innovation Network and PCORnet: Collaborations and Synergies


Collaborative research; Trial Innovation Network; CTSA; Clinical research; Healthcare systems; Common data model; Evidence-based research; PCORnet; PCORI; ADAPTABLE; National Center for Advancing Translational Sciences; SMART IRB

Key Points

  • The Trial Innovation Network (a CTSA program) and the National Patient-Centered Clinical Research Network (PCORnet) are two national, mission-aligned research networks designed for trial efficiency, excellence, and innovation.
  • Common goals of these networks include:
    – Creating a durable research infrastructure
    – Optimizing data use
    – Enhancing stakeholder engagement
    – Streamlining trial administration
  • The Trial Innovation Network is a living laboratory for innovating key elements of clinical trials. It serves as a resource for NIH Institutes and Centers, industry, and other partners. A major goal is to harmonize network elements to clear roadblocks around collaboration, protocols, central IRBs, recruitment, and data standards.
  • PCORnet is a national evidence system comprising a community of clinical research that unites data from patients, clinicians, and healthcare systems. PCORnet represents data from millions of patients who have had a medical encounter in the past 5 years.
  • PCORnet’s ADAPTABLE aspirin study is a large pragmatic trial designed with highly engaged patients as “Adaptors” and uses electronic patient screening, enrollment, and followup.

Discussion Themes

These networks also value methodological proposals and use cases that explore how collaboration can work.

This kind of collaboration toward effective and efficient clinical research is very important to patients—every hour counts.

Could a long-term vision be to synergize with small community practices, such as the Practice-Based Research Networks?

For More Information

To learn more about how the proposal process works, visit the Trial Innovation Network website.

Visit PCORnet’s ADAPTABLE study website for more details on this large national trial.

#TrialInnovationNetwork, #pctGR
@NCATS_NIH_Gov, @ADAPTABLEstudy, @PCTGrandRounds, @Collaboratory1, @PCORnetwork

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