April 21, 2017: Testing New Models of Research Funding

April 21, 2017: Testing New Models of Research Funding

Slides: Slides


Testing New Models of Research Funding: One Brave Idea


Calum A. MacRae, MD, PhD, Chief of Cardiovascular Medicine at Brigham and Women’s Hospital, Associate Professor of Medicine at Harvard Medical School, and Principal Investigator of the One Brave Idea™ project.


Coronary heart disease; One Brave Idea; American Heart Association; Phenotypes; Clinical datasets; Clinical genomics; Research funding; Team science; Discovery research

Key Points

  • One Brave Idea supports groundbreaking research aimed at preventing or reversing coronary heart disease. Funding is through a joint collaborative of the American Heart Association, Verily, and AstraZeneca.
  • Among the goals of this 5-year research project are to identify new and earlier true endophenotypes, discover new disease genes and environmental contributors, and implement new therapeutic and preventive strategies.
  • The aim is to advance systematic approaches to acquiring the right information content to transform care delivery, research, and education. The project also explores novel approaches to research funding, joint investments, and partnerships.

Discussion Themes

What policies are you establishing regarding data governance and data sharing?

Would other research domains, such as Alzheimer’s or diabetes, be amenable to this creative strategy?

This approach could be feasible in other areas because it is focused on problem-solving and aligning the right groups of people to solve problems. It’s important not to restrict too narrowly who can contribute to the solution.

This project is an experiment in how research is funded—and how funders interact with a study team. The award sponsors are interested in finding a sustainable way to expand this model to other projects.

For More Information

Read more about Dr. MacRae’s coronary heart disease research at http://www.onebraveidea.com/thewinningidea/.

#OneBraveIdea, #pctGR
@PCTGrandRounds, @Collaboratory1, @PCORnetwork

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