December 14, 2025: The NIH Pragmatic Trials Collaboratory hosted a workshop at AcademyHealth's 18th Annual Conference on the Science of Dissemination and Implementation in Health. The workshop introduced concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems, with a focus on methods relevant to health services researchers.
Agenda and Slides
Morning Sessions
Welcome and Opening Remarks
Emily O'Brien, PhD
Session 1: Embedded Pragmatic Clinical Trials (ePCTs) and Hybrid Effectiveness-Implementation Trials: Similarities and Differences
Hayden Bosworth, PhD
Session 2: Design and Analysis Considerations
Qilu Yu, PhD
Session 3: Measuring Effectiveness and Implementation Outcomes
Angelo Volandes, MD, MPH
Session 4: ePCTs in Context: Small Group Work Followed by Panel Discussion With NIH Collaboratory Trial PIs
Moderator: Emily O'Brien, PhD
*This session includes case study presentations.
Afternoon Sessions
Session 5: Pilot and Feasibility Testing
Lanay Mudd, PhD
Session 6: Ethical and Regulatory Considerations and Posttrial Obligations
Stephanie Morain, PhD, MPH
Session 7: Engaging and Aligning With Health System and Community Partners
Hayden Bosworth, PhD
Session 8: Posttrial Sustainment or Deimplementation of Study Interventions
Vince Mor, PhD
Session 9: ePCTs in Context: Small Group Work Followed by Panel Discussion With NIH Collaboratory Trial PIs
Moderator: Stephanie Morain, PhD, MPH
*This session includes case study presentations.
Session 10: Writing a Compelling Grant Application
Beda Jean-Francois, PhD
Closing Remarks
Beda Jean-Francois, PhD
Case Studies
Examples from the NIH Collaboratory Trials
ACP PEACE: Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly (Angelo Volandes, MD, MPH)
BeatPain Utah: Nonpharmacologic Pain Management in Federally Qualified Health Centers Primary Care Clinics (Julie Fritz, PhD, PT)
LungSMART Utah: Population Health Management Approaches to Increase Lung Cancer Screening in Community Health Centers (David Wetter, PhD, MS)
RAMP: Reaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (Diana Burgess, PhD)
PROVEN: Pragmatic Trial of Video Education in Nursing Homes (Vincent Mor, PhD)