April 27, 2018: Expanding Use of Real-World Evidence: A National Academies Workshop Series


Greg Simon, MD, MPH
Senior Investigator
Kaiser Permanente Washington Health Research Institute


Expanding Use of Real-World Evidence: A National Academies Workshop Series


Clinical research; Real-world evidence; Real-world data; Pragmatic research

Key Points

  • Real-world evidence (RWE) should be generalizable, relevant, adaptable, and efficient.
  • Are our research traditions vital anchors to our central purpose? Or just anchors that keep us stuck?
  • Real-world data (RWD) does not always make real world evidence (RWE), but RWE usually starts with RWD.
  • The real-world evidence (RWE) mantra is “faster, better, cheaper.”

Discussion Themes

The third workshop will be held in July of 2018 and will be focused on generating useful tools that stakeholders might use regarding when and how to use real-world evidence.

Is the term “real world evidence” starting to have so many meanings that it is losing meaning?  It is a broad term that includes real-world data, real-world treatment, and real-world treatment assignment.

It is essential to make a clear decision to define usual care, assess it during a trial, and report on it. The question is how much do researchers try to control usual care? There are situations when there is an ethical obligation to provide a certain level of care.

Transparency regarding methods and intermediate data steps is necessary for credibility.


For information on the real-world evidence workshops, visit http://bit.ly/RWEworkshop1 and http://bit.ly/RWEworkshop2 


@Collaboratory1, @GregSimonKPWHRI, #realworldevidence, #realworlddata, #pragmatictrial, #pctGR

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