In this Friday’s PCT Grand Rounds, Eric Perakslis of Duke University will present “AI & ML: Want to Play a Game?” The Grand Rounds session will be held on Friday, August 4, 2023, at 1:00 pm eastern. Perakslis is a professor in population health sciences and the chief research technology strategist in the Duke University School of ...

With the NIH Pragmatic Trials Collaboratory entering its second decade, we are expanding our presence on the LinkedIn social media platform to promote research that advances the design, conduct, and dissemination of pragmatic clinical trials. If you are active on LinkedIn, we invite you to follow our page for the latest news about our innovative NIH ...

The NIH this month published notice of a funding opportunity to support the next round of pragmatic clinical trials within the NIH-DoD-VA Pain Management Collaboratory (PMC). Read the full notice of funding opportunity (RFA-AT-24-004). The PMC was established in 2017 with an initial cohort of 11 pragmatic trials. The new funding opportunity leverages the experience, expertise, and ...

Leaders of the NIH Pragmatic Trials Collaboratory hosted an onboarding meeting for the program’s 3 newest NIH Collaboratory Trials. The projects joined the program under the UG3 cooperative agreement mechanism to support a 1-year planning phase in preparation for potential transition to a UH3 implementation phase. Access the complete materials from the onboarding session. During the session, ...

In this Friday’s PCT Grand Rounds, Professor Carl Bergstrom of the University of Washington will present “How Can Researchers Fight Misinformation About Medicine?” The Grand Rounds session will be held on Friday, July 28, 2023, at 1:00 pm eastern. Bergstrom is a professor of biology at the University of Washington. He writes frequently on the spread of ...

At the NIH Pragmatic Trials Collaboratory Steering Committee’s annual meeting in May, Dr. Stephanie Morain discussed the results of a recent bioethics initiative to explore ethical considerations for data sharing in the context of pragmatic clinical trials. The project was supported by a supplemental grant award from the NIH through the NIH HEAL Initiative. Morain and ...

In a new episode of our Rethinking Clinical Trials podcast, Dr. Julie Fritz speaks with host Dr. Adrian Hernandez about partnering with community health centers in the BeatPain Utah study. Fritz and colleague Dr. Guilherme Del Fiol presented on their experiences during the June 16 session of Grand Rounds. Listen to the latest podcast episode on ...

In this Friday’s PCT Grand Rounds, Dr. Christine Goertz and Dr. Adam Goode of Duke University will present “Implementing New Care Pathways for Low Back Pain in Academic Healthcare Systems: Early Lessons From IMPACt-LBP.” The Grand Rounds session will be held on Friday, July 21, 2023, at 1:00 pm eastern. IMPACt-LBP, an NIH Pragmatic Trials Collaboratory Trials, ...

In an interview at the annual NIH Pragmatic Trials Collaboratory Steering Committee meeting, Dr. Lynn DeBar and Dr. Natalia Morone had a conversation about sharing trial results with participant partners. Both also participated in a discussion session about the challenges and value of results dissemination. DeBar is a principal investigator of the BackInAction and PPACT ...

The NIH Pragmatic Trials Collaboratory is welcoming its first class of fellows in a new program for early-career investigators with a scholarly interest in pragmatic clinical trials. “We are very excited to welcome the 2 inaugural fellows to the NIH Pragmatic Trials Collaboratory Fellowship Program and give them the education and tools that they need to ...

At the NIH Pragmatic Trials Collaboratory Steering Committee Meeting in May, we interviewed Dr. Adrian Hernandez about how to better promote data sharing. Hernandez is a co–principal investigator of the program’s Coordinating Center and the executive director of the Duke Clinical Research Institute. “We have to change the incentive structure because we still have barriers for ...

In this Friday’s PCT Grand Rounds, Christopher Granger and Neha Pagidipati of Duke University will present “Lessons From the COORDINATE-Diabetes Trial.” The Grand Rounds session will be held on Friday, July 14, 2023, at 1:00 pm eastern. The Coordinating Cardiology Clinics Randomized Trial of Interventions to Improve Outcomes (COORDINATE)–Diabetes was a cluster randomized trial assessing the effect ...

Complete materials are now available from the NIH Pragmatic Trials Collaboratory’s recent workshop, “Driving Tomorrow’s Outcomes Through Clinical Research in Real-World Settings.“ The 2-day workshop, held in June at the 2023 AcademyHealth Annual Research Meeting in Seattle, introduced concepts in the design, conduct, and implementation of pragmatic clinical trials embedded in healthcare systems, with a focus ...

The NIH Collaboratory is excited to announce the addition of Chat 4 Heart Health to its portfolio of innovative NIH Collaboratory Trials. The American Heart Association (AHA) identifies Life’s Essential 8 (LE8) lifestyle factors as eating better, being more active, quitting tobacco, getting healthy sleep, managing weight, controlling cholesterol, managing blood sugar, and managing blood pressure. ...

In an interview at the NIH Pragmatic Trials Collaboratory Steering Committee Meeting in May, Keith Marsolo, PhD, Co-Chair of the Electronic Health Records Core, reflected on data sharing experiences from the program and factors affecting the meaningful re-use of data. “The data sharing experiences from the NIH Pragmatic Trials Collaboratory Trials have been fairly limited. Most ...

The NIH Pragmatic Trials Collaboratory is excited to add 2 new NIH Collaboratory Trials to its portfolio of innovative pragmatic clinical trials embedded in healthcare systems. BEST-ICU (or Behavioral Economic and Staffing Strategies to Increase Adoption of the ABCDEF Bundle in the ICU) is supported by the National Heart, Lung, and Blood Institute (NHLBI). TAICHIKNEE ...

In this Friday’s PCT Grand Rounds, Ankeet Bhatt of the Kaiser Permanente Northern California Division of Research will present “Implementing Virtual Strategies Across an Integrated Healthcare System: The IMPLEMENT-HF Study.” The Grand Rounds session will be held on Friday, July 7, 2023, at 1:00 pm eastern. Dr. Bhatt is an associate physician at the Kaiser Permanente San ...

Pragmatic research is vulnerable to differences in data capture and access to care for different subsets of the population, which, if left unaddressed, can worsen health gaps. In a new article published online ahead of print in JAMIA, the NIH Pragmatic Trials Collaboratory’s Trial teams reflect on the challenges encountered by their trials and share the ...

In the latest episode of the NIH Collaboratory Grand Rounds podcast, Dr. Joshua Denny continues his discussion about All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine. The full May 5 Grand Rounds webinar with Dr. Denny is also available.

Materials and videocast recordings are now available from the NIH Pragmatic Trials Collaboratory’s recent workshop, “Getting the Right Evidence to Decision-Makers Faster.” The 2-day workshop explored the critical cycle of evidence generation by researchers to decision-making by healthcare system leaders to implement the findings of pragmatic clinical trials conducted within healthcare systems. Access the complete workshop ...

In an interview during the annual Steering Committee meeting, Drs. Rosa Gonzalez-Guarda and Cherise Harrington, cochairs of the Health Equity Core Working Group, shared insights and next steps for health equity in the NIH Pragmatic Trials Collaboratory. One question discussed at the meeting was how to embed health equity in pragmatic clinical trials. Gonzalez-Guarda said that ...

In this Friday’s PCT Grand Rounds, Adrian Hernandez, Pamela Tenaerts, and Craig Lipset will present “Decentralized Trials – From Guidance to Reality & What’s Left.” The Grand Rounds session will be held on Friday, June 30, 2023, at 1:00 pm eastern. Dr. Hernandez is a professor of medicine and director of the Duke Clinical Research Institute at ...

A focus of the 2023 NIH Pragmatic Trials Collaboratory Annual Steering Committee Meeting was health equity in embedded pragmatic clinical trials (ePCTs). In an interview during the meeting, Drs. Anne Trontell and Ana Quiñones reflected on health equity in the ePCT landscape. Trontell, who is the associate director for comparative clinical effectiveness research at the Patient-Centered ...

This year’s annual Steering Committee meeting for the NIH Pragmatic Trials Collaboratory featured health equity as a central topic of discussion. In an interview after his keynote presentation, Eliseo J. Pérez-Stable, MD, Director of the National Institute on Minority Health and Health Disparities (NIMHD), shared his thoughts on national priorities for reducing health disparities and ...

Researchers from EMBED, an NIH Pragmatic Trials Collaboratory Trials, found a sharp rise in out-of-hospital overdose deaths in the early years of the COVID-19 pandemic, attributable largely to increasing involvement of fentanyl. The findings were published online ahead of print this week in the New England Journal of Medicine. EMBED was a cluster randomized trial across 21 ...

At the annual NIH Pragmatic Trials Collaboratory Steering Committee meeting in May, we interviewed Taunton Paine, director of the NIH Scientific Data Sharing Policy Division, about the NIH’s new Data Management & Sharing Policy, which took effect in 2023. Under the new policy, all NIH-funded research requires a submission plan that describes how, where, and when ...

In this Friday’s PCT Grand Rounds, Miguel Vazquez of the University of Texas Southwestern Medical Center and George “Holt” Oliver of the Parkland Center for Clinical Innovation will present “Improving Delivery of Care for Chronic Kidney Disease, Diabetes, and Hypertension,” including results from the ICD-Pieces NIH Collaboratory Trial. The Grand Rounds session will be held on ...

This year’s annual Steering Committee meeting for the NIH Pragmatic Trials Collaboratory featured 2 special guests from the US Food and Drug Administration’s Digital Health Center of Excellence—Matthew Diamond, MD, PhD, Chief Medical Officer, and Sonja Fulmer, PhD, Acting Deputy Director. They joined to share information on the FDA’s approach to clinical decision support (CDS) ...

Updated study snapshots and ethics and regulatory documentation are now available for the IMPACt-LBP and INSPIRE trials, both NIH Pragmatic Trials Collaboratory Trials. IMPACt-LBP transitioned from the planning phase to the implementation phase in August. As part of the transition, the study team reviewed and updated the minutes of their initial consultation with the Ethics and ...

In this Friday’s PCT Grand Rounds, Julie Fritz and Guilherme Del Fiol of the University of Utah will present “BeatPain Utah Pragmatic Clinical Trial: Partnering With Community Health Centers Within a Socio-Technical Framework.” The Grand Rounds session will be held on Friday, June 16, 2023, at 1:00 pm eastern. BeatPain Utah, an NIH Collaboratory Trials, is studying ...

On May 16-17, 2023, over 100 members of the NIH Pragmatic Trials Collaboratory met in Bethesda, Maryland, for its annual Steering Committee meeting—an opportunity to network and hold rich discussions on key issues related to pragmatic research. In an interview with Wendy Weber, NIH Project Officer, and Lesley Curtis, co-principal investigator of the Coordinating Center, ...

The Long-Term Care (LTC) Data Cooperative this week announced a request for applications for the newly established 2023 Real World Data Scholars Program. This program supports the development of advanced graduate students, postdoctoral fellows, and early-career faculty who are interested in developing their expertise and experience in working with electronic health record (EHR) data. The program offers ...

In this Friday’s PCT Grand Rounds, Shirley Wang of Harvard Medical School will present “Emulating Randomized Clinical Trials With Non-randomized Real-World Evidence Studies: Results From the RCT DUPLICATE Initiative.” The Grand Rounds session will be held on Friday, June 9, 2023, at 1:00 pm eastern. The DUPLICATE initiative is building an empirical evidence base for using ...

In an interview at the annual NIH Pragmatic Trials Collaboratory Steering Committee meeting in Bethesda, Maryland, Richard Platt, MD, MS (co-principal investigator) and Shruti Gohil, MD, MPH (lead investigator) of the INSPIRE NIH Collaboratory Trial shared the status of the trials, discussed recent lessons learned, described the impact they hope their trials will have on the ...

Register today! The NIH Pragmatic Trials Collaboratory will host a virtual workshop June 20-21, 2023, to explore the critical cycle of evidence generation to decision by health system leaders to implement the findings of pragmatic clinical trials (PCTs). The workshop, “Getting the Right Evidence to Decision-Makers Faster,” will kick off on Tuesday, June 20, at 11:00 ...

In this Friday’s PCT Grand Rounds, John Alexander of Duke University will present “PROACT Xa and the Wizard of Oz: Behind the Curtain of a Pragmatic Decentralized Clinical Trial.” The Grand Rounds session will be held on Friday, June 2, 2023, at 1:00 pm eastern. PROACT Xa was a prospective, randomized clinical trial conducted to determine ...

In a secondary analysis from the EMBED pragmatic clinical trial, Black patients with opioid use disorder were less likely than White patients to be initiated on buprenorphine in the emergency department. The study’s findings were published recently in Academic Emergency Medicine. EMBED, an NIH Collaboratory Trial, was a cluster randomized trial across 21 emergency departments in 5 ...

In this Friday’s PCT Grand Rounds, Robert O’Toole of the University of Maryland will present “Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis After a Fracture.” The Grand Rounds session will be held on Friday, May 19, 2023, at 1:00 pm eastern. Dr. O’Toole is the chief of Orthopaedics at the R. Adams Cowley Shock Trauma Center, head ...

Organizational culture, clinician training and support, the ability to link patients to ongoing treatment, and the ability to tailor implementation to each clinical site were key determinants of successful implementation of an intervention to promote buprenorphine initiation in emergency departments, according to a qualitative study conducted as part of the EMBED pragmatic clinical trial. The study’s ...

A new article from the NIH Pragmatic Trials Collaboratory outlines stakeholder insights and ethical considerations related to sharing deidentified, participant-level data in pragmatic clinical trials. While there are numerous arguments for and against data sharing in the context of pragmatic trials, the report aims to address the gap in documented stakeholder perspectives. The article was published ...

In this Friday’s PCT Grand Rounds, Richelle Koopman of the University of Missouri will present “Design and Pragmatic Trial of COACH: A Patient Portal/EHR Information System for Home Blood Pressure Monitoring in Hypertension.” The Grand Rounds session will be held on Friday, May 12, 2023, at 1:00 pm eastern. Dr. Koopman is professor and vice chair for ...

The NIH Pragmatic Trials Collaboratory is partnering with AcademyHealth to offer a 1.5-day preconference workshop at the 2023 Annual Research Meeting in Seattle, Washington. The workshop, “Driving Tomorrow’s Outcomes Through Clinical Research in Real-World Settings,” will cover the essentials of embedded healthcare systems research, along with strategies for conducting clinical trials that provide real-world evidence necessary ...

In this Friday’s PCT Grand Rounds, Joshua Denny of the All of Us Research Program at NIH, will present “All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine.” The Grand Rounds session will be held on Friday, May 5, 2023, at 1:00 pm eastern. Dr. Denny is the chief executive ...

The NIH Pragmatic Trials Collaboratory published a new chapter of its Living Textbook of Pragmatic Clinical Trials this week. The chapter, “Intervention Delivery and Complexity,” illustrates that—although an intervention may be simple—the actual delivery of the intervention may be complex due to factors such as new workflows, special training of frontline staff, and the number of components ...

In this Friday’s PCT Grand Rounds, Matthew Semler of Vanderbilt University will present “Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation: An Embedded Cluster-Crossover Trial.” The Grand Rounds session will be held on Friday, April 28, 2023, at 1:00 pm eastern. Dr. Semler is an assistant professor of medicine and bioinformatics and the medical director ...

In the latest episode of the NIH Collaboratory Grand Rounds podcast, Drs. Russell Rothman, Erin Holve and Lesley Curtis continue their discussion about PCORnet – From Observational Studies to Pragmatic Clinical Trials: (Almost) A Decade of Research in PCORnet®. The full March 24 Grand Rounds webinar with Drs. Rothman and Holve is also available.

An upcoming webinar in the NIH HEAL Initiative’s HEAL Headliners series will highlight the experiences of 2 projects in meaningfully engaging patients and community partners throughout the research process to ensure that the findings have the greatest public health impact. The webinar will be held on Friday, May 5, 2023, at 2:00 pm eastern. Rosemarie Martin ...

The NIH Pragmatic Trials Collaboratory is partnering with AcademyHealth to offer a 1.5 day pre-conference workshop at the 2023 Annual Research Meeting in Seattle, Washington. The workshop, “Driving Tomorrow’s Outcomes Through Clinical Research in Real-World Settings: Essentials of Embedded Pragmatic Clinical Trials Workshop,” will provide an introduction to the investigative opportunities for embedded health systems ...

In this Friday’s PCT Grand Rounds, Amit Garg and Stephanie Dixon of Western University’s Schulich School of Medicine & Dentistry will present “Personalised Cooler Dialysate for Patients Receiving Maintenance Haemodialysis (MyTEMP): A Pragmatic, Cluster-Randomised Trial.” The Grand Rounds session will be held on Friday, April 21, 2023, at 1:00 pm eastern. Dr. Garg is a professor ...

In this Friday’s PCT Grand Rounds, Kanecia Zimmerman of Duke University will present “RECOVER in Action: Status of Clinical Trial Protocols.” The Grand Rounds session will be held on Friday, April 14, 2023, at 1:00 pm eastern. Dr. Zimmerman is an associate professor of pediatrics in the Duke University School of Medicine. The Researching COVID to ...