The NIH Pragmatic Trials Collaboratory this week published a new chapter in its Living Textbook of Pragmatic Clinical Trials. Part of the Living Textbook’s new Ethics and Regulatory collection, the chapter discusses the logistics of using a single IRB (sIRB).
In 2016, the NIH issued a policy establishing the expectation that a “single IRB of record” will be used for all NIH-funded, multisite, human subjects research. The 2017 revision of the Common Rule likewise sets out a requirement for sIRB review of cooperative research.
The new chapter on sIRBs in the Living Textbook covers:
- The process for setting up an sIRB
- The responsibilities of “relying institutions”
- Working with an sIRB while conducting research