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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures

Partnering With Quality Improvement and Population Health Initiatives- ARCHIVED

CHAPTER SECTIONS

ARCHIVED PAGE

Archived on August 7, 2025. Go to the latest version.

Dissemination and Implementation


Section 10


Partnering With Quality Improvement and Population Health Initiatives- ARCHIVED

Expand Contributors
Douglas Zatzick, MD

Leah Tuzzio, MPH

David Chambers, DPhil

Jerry Suls, PhD

Doyanne Darnell, PhD

Gloria Coronado, PhD

Lynn DeBar, PhD, MPH

 

Beverly Green, MD, MPH

Susan S. Huang, MD, MPH

Jeffrey G. Jarvik, MD, MPH

Edward Septimus, MD, FACP

Gregory Simon, MD, MPH

Miguel Vazquez, MD

Contributing Editor
Karen Staman, MS

When developing and implementing a pragmatic study, it is may be useful to partner with quality improvement and population health personnel at sites; if the results of the PCT are positive, they may align with organizational goals for improving care. Tools and technologies can be developed so they are easily adaptable for use in various departments with different electronic health record systems.

Case Example: ICD-Pieces

  • The goal of the Improving Chronic Disease Management with Pieces (ICD-Pieces) trial is to improve care for patients with chronic kidney disease, diabetes, and hypertension by using a novel technology platform (Pieces) that uses the electronic health record to identify patients and by assigning practice facilitators within primary care practices or community medical homes.

The investigators of ICD-Pieces used a novel information technology (Pieces) to identify patients with chronic kidney disease, diabetes, and hypertension through the electronic health record and assign practice facilitators to these patients to improve their care. Pieces can be integrated into various electronic health record systems—Epic, CPRS, All Scripts, or customized spreadsheets. The IT algorithms in ICD-Pieces were designed to be relatively simple for the IT team to implement should the healthcare system decide to allocate resources for this purpose, as improving the care of patients with multiple co-morbidities aligns with quality improvement and population health goals.

If the results are positive, participating healthcare systems would implement the results in different manners, but it is likely that quality improvement or population medicine groups would drive the uptake.

Strategy Details
Diffusion Once results are available there will be initial presentations to administrators and clinical leaders. Next steps will include presentations to other groups in the healthcare system and publication of trial results
Dissemination Investigators will have information about how many hospitalizations, readmissions, emergency room visits, cardiovascular events and deaths could be potentially saved through the intervention. This could be translated into better outcomes and even cost savings. Healthcare systems will be interested in this information.  Visits to clinics, education sessions and webinars will be held in the participating sites.
Implementation If trial demonstrates value, quality improvement and population health departments will allocate IT resources and practice facilitators across healthcare systems. Patient lists, practice alerts and order sets will be available for use across the healthcare systems.
Sustainability If quality of care measures improve after implementing the intervention—and the detection of patients translates into better care, then it is expected that quality improvement and population medicine departments will continue to coordinate allocation of IT resources and practice facilitators and monitor performance to drive long-term sustainability.

Previous Section Next Section

SECTIONS

CHAPTER SECTIONS
sections

  1. Introduction – ARCHIVED
  2. Dissemination and Implementation Frameworks – ARCHIVED
  3. Let It, Help It, Make It Happen – ARCHIVED
  4. Changes to Policy and Guidelines – ARCHIVED
  5. Legislative Changes- ARCHIVED
  6. Creation of Targeted Tools- ARCHIVED
  7. Stepped Wedge Designs- ARCHIVED
  8. Intervention Staffing and Training Flexibility- ARCHIVED
  9. Pragmatic Implementation Process Assessments- ARCHIVED
  10. Partnering With Quality Improvement and Population Health Initiatives- ARCHIVED
  11. Implementation in the Trial Versus in the Real World- ARCHIVED
  12. Additional Resources- ARCHIVED
  13. FAQ- ARCHIVED


Version History

Published August 25, 2017

current section :

Partnering With Quality Improvement and Population Health Initiatives- ARCHIVED

  1. Introduction – ARCHIVED
  2. Dissemination and Implementation Frameworks – ARCHIVED
  3. Let It, Help It, Make It Happen – ARCHIVED
  4. Changes to Policy and Guidelines – ARCHIVED
  5. Legislative Changes- ARCHIVED
  6. Creation of Targeted Tools- ARCHIVED
  7. Stepped Wedge Designs- ARCHIVED
  8. Intervention Staffing and Training Flexibility- ARCHIVED
  9. Pragmatic Implementation Process Assessments- ARCHIVED
  10. Partnering With Quality Improvement and Population Health Initiatives- ARCHIVED
  11. Implementation in the Trial Versus in the Real World- ARCHIVED
  12. Additional Resources- ARCHIVED
  13. FAQ- ARCHIVED

Citation:

Zatzick D, Tuzzio L, Chambers D, et al. Dissemination and Implementation: Partnering With Quality Improvement and Population Health Initiatives- ARCHIVED. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Pragmatic Trials Collaboratory. Available at: https://rethinkingclinicaltrials.org/chapters/dissemination/dissemination-implementation-top/partnering-with-quality-improvement-and-population-health-initiatives/. Updated December 3, 2025. DOI: 10.28929/080.

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