NIH Collaboratory Trials
Our Reach
NIH Collaboratory Trials are large-scale pragmatic clinical trials conducted in partnership with healthcare systems. They cover a range of clinical areas and have a wide variety of interventions and study designs. Learn more about each trial on their individual webpages (linked below). New trials join the program regularly and receive onboarding to connect them with services of the Coordinating Center.
pragmatic trials
clinical sites
patients
NIH Institutes + Centers
PRISM Trials
AIM-CP
Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients with Chronic Pain
Sebastian Tong, Kushang Patel
University of Washington
APA-SM
Jennifer Kawi, Jane Bolin, Hulin Wu
University of Texas Health Science Center at Houston
ARBOR-Telehealth
Advancing Rural Back Pain Outcomes through Rehabilitation Telehealth
Richard Skolasky Jr., Kevin McLaughlin
Johns Hopkins University
BeatPain Utah
Julie Fritz
University of Utah
CARNATION
Coordinated cARe paiN mAnagement Technology ImplementatiON (CARNATION)
Lynn DeBar, Rachel Gold, Nicole Cook
Kaiser Foundation Research Institute
EquiP PC
Equitable Primary Care for Pain Care (EquiP PC)
Kari Stephens, Roger Kessler
University of Washington
FM-TIPS
Fibromyalgia TENS in Physical Therapy Study (FM-TIPS)
Leslie Crofford, Kathleen Sluka
University of Iowa
GRACE
Ardith Doorenbos, Judith Schlaeger, Robert Molokie, Miriam Ezenwa, Nirmish Shah
University of Illinois at Chicago
NOHARM
Nonpharmacologic Options in Postoperative Hospital-based And Rehabilitation Pain Management (NOHARM)
Andrea Cheville, Jon Tilburt
Mayo Clinic Rochester
OPTIMUM
Natalia Morone
Boston Medical Center
RAMP
Diana Burgess, Roni Evans, Katherine Hadlandsmyth
Center for Veterans Research and Education
Other Active Trials
BEST-ICU
Michele Balas, Eduard Vasilevskis
University of Nebraska Medical Center
Chat 4 Heart Health
Michael Ho, Sheana Bull
University of Colorado Denver
GGC4H
Margaret Kuklinski, Stacy Sterling
University of Washington
I CAN DO Surgical ACP
Elizabeth Wick, Genevieve Melton-Meaux, Rebecca Sudore
University of California, San Francisco
IMPACt-LBP
Implementation of the American College of Physicians Guideline for Low Back Pain (IMPACt-LBP)
Christine Goertz, Adam Goode, Jon Lurie, Hrishikesh Chakraborty
Duke University
iPATH
Implementing Scalable, PAtient-centered Team-based Care for Adults with Type 2 Diabetes (iPATH)
Sara Singer
Stanford University
LungSMART
David Wetter, Guilherme Del Fiol, Kensaku (Ken) Kawamoto
University of Utah
MOMs Chat & Care Study
Stephanie Fitzpatrick
Feinstein Institute for Medical Research
STEP-2
Self-Testing for Cervical Cancer in Priority Populations (The STEP-2 Trial)
Rachel Winer, Amanda Petrik, Jasmin Tiro
University of Washington
TAICHIKNEE
Remote Tai Chi for Knee Osteoarthritis: an Embedded Pragmatic Trial (TAICHIKNEE)
Chenchen Wang, Helen Lavretsky, Eric Roseen, Robert Saper
Tufts Medicine Tufts Medical Center
Completed Trials
ABATE Infection
Active Bathing to Eliminate (ABATE) Infection
Susan Huang
University of California, Irvine
ACP PEACE
James Tulsky, Angelo Volandes
Dana-Farber Cancer Institute
BackInAction
Pragmatic Trial of Acupuncture for Chronic Low Back Pain in Older Adults (BackInAction)
Lynn DeBar, Andrea Cook
Kaiser Foundation Research Institute
EMBED
Edward Melnick, Gail D'Onofrio
Yale University
HiLo
Hrishikesh Chakraborty
Duke University
ICD-Pieces
Improving Chronic Disease Management with Pieces (ICD-Pieces™)
Miguel Vazquez
UT Southwestern Medical Center
INSPIRE
Susan Huang, Rich Platt, Shruti Gohil
Harvard Pilgrim Health Care
Nudge
Michael Ho, Sheana Bull
University of Colorado
PRIM-ER
Primary Palliative Care for Emergency Medicine (PRIM-ER)
Corita Grudzen, Keith Goldfeld
New York University School of Medicine
PROVEN
Pragmatic Trial of Video Education in Nursing Homes (PROVEN)
Vincent Mor, Angelo Volandes, Susan Mitchell
Brown University School of Medicine
SPOT
Suicide Prevention Outreach Trial (SPOT)
Gregory Simon
Kaiser Permanente Washington Health Research Institute
STOP CRC
Strategies and Opportunities to Stop Colorectal Cancer (STOP CRC)
Gloria Coronado, Beverly Green
Kaiser Foundation Research Institute
TiME
Time to Reduce Mortality in End-Stage Renal Disease (TiME)
Laura Dember
University of Pennsylvania
TSOS
Douglas Zatzick
University of Washington
Planning Completed
Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory highlights NIH Collaboratory Trial experiences.