November 6, 2025: Enrollment Begins for APA-SM and iPATH Trials

Two of the newest NIH Collaboratory Trials have begun enrollment. Congratulations to the study teams from APA-SM and iPATH for reaching this important project milestone!

APA-SM Investigators

APA-SM is enrolling patients in a 4-week auricular point acupressure intervention for self-management of chronic pain in rural communities in South Carolina and Texas. The study will also include implementation outcomes, a cost-effectiveness analysis, and an evaluation of predictive factors for treatment response. The study is led by principal investigators Jennifer Kawi and Hulin Wu of UTHealth Houston and Jane Bolin of Texas A&M University.

APA-SM is supported within the NIH Pragmatic Trials Collaboratory by the National Center for Complementary and Integrative Health, with additional oversight from the National Institute of Neurological Disorders and Stroke. Learn more about APA-SM.

Headshot of Dr. Sara Singer

iPATH, led by principal investigator Sara Singer of Stanford University, is enrolling federally qualified health centers in California, Massachusetts, Ohio, and Puerto Rico in a stepped-wedge, cluster randomized, hybrid effectiveness-implementation trial of a practice transformation strategy for type 2 diabetes. The study will evaluate the impact of the practice transformation strategy and identify process elements that influence implementation effectiveness.

iPATH is supported within the NIH Pragmatic Trials Collaboratory by the National Institute on Minority Health and Health Disparities. Learn more about iPATH.