April 11, 2022: The NIH Pragmatic Trials Collaboratory hosted a Pre-Conference Workshop at the 2022 Health Care Systems Research Network (HCSRN) Annual Conference. This training workshop introduced concepts in the design, conduct, and implementation of embedded pragmatic clinical trials (ePCTs) and provided firsthand ePCT experiences and case studies from the NIH Pragmatic Trials Collaboratory Trials.
Agenda and Slides
Welcome and Introduction
Kevin Weinfurt, PhD
Session 1: What Are Embedded PCTs (ePCTs)?
Kevin Weinfurt, PhD
Session 2: Objectives and Trial Design: An Overview of Hybrid Design
Devon Check, PhD
Session 3: Measuring Outcomes
Devon Check, PhD
Session 4: ePCT Experimental Design & Analysis
Patrick Heagerty, PhD
Agenda and Slides
Session 5: Pilot & Feasibility Testing
Miguel Vazquez, MD
Session 6: Ethical & Regulatory Oversight Considerations
Kevin Weinfurt, PhD
Session 7: Writing a Compelling Grant Application
Michael Ho, MD, PhD
Session 8: ePCTs in Context: Panel Discussion
Moderator: Kevin Weinfurt, PhD
*This presentation contains case studies.
Session 9: Next Steps
Kevin Weinfurt, PhD
Case Studies
Examples from NIH Collaboratory Trials:
- Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications (The Nudge Study) (Michael Ho, MD, PhD)
- Improving Chronic Disease Management with Pieces (ICD-Pieces) (Miguel Vazquez, MD)
- Guiding Good Choices for Health (GGC4H): Three Large Healthcare Systems (Stacy Sterling, DrPH, MPI)